Basic Information:

  VIRBase ID:  

HHID00076303

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Ptgs2:  NM_011198     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Ptgs2
miRBase Accession/Entrez ID	MIMAT0000230	19225
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	COX//Cox-//Cox-2//COX2//gripghs//PES-2//Pgh//PGHS//PGHS-2//Pghs2//PHS//PHS II//PHS-2//Tis//TIS10

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Ptgs2	chr1:150100067-150100068(+) m6A 5'UTR       24981863 chr1:150100108-150100109(+) m6A 5'UTR       24981863//25569111 chr1:150100141-150100142(+) m6A 5'UTR       24981863//25569111 chr1:150100158-150100159(+) m6A 5'UTR       24981863//25569111 chr1:150105081-150105082(+) m6A CDS       24981863//25569111 chr1:150105430-150105431(+) m6A CDS       24981863//25569111 chr1:150105457-150105458(+) m6A CDS       24981863//25569111 chr1:150105485-150105486(+) m6A CDS       24981863//25569111 chr1:150105523-150105524(+) m6A CDS       24981863//25569111 chr1:150105692-150105693(+) m6A CDS       24981863//25569111//22608085 chr1:150105727-150105728(+) m6A CDS       24981863//25569111//22608085 chr1:150105896-150105897(+) m6A 3'UTR       24981863 chr1:150107602-150107603(+) m6A 3'UTR       24981863 chr1:150107636-150107637(+) m6A 3'UTR       24981863 chr1:150107668-150107669(+) m6A 3'UTR       24981863 chr1:150107711-150107712(+) m6A 3'UTR       24981863 chr1:150107724-150107725(+) m6A 3'UTR       24981863 chr1:150107764-150107765(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Ptgs2

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).