Basic Information:

  VIRBase ID:  

HHID00076299

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Ppp1r14b:  NM_008889     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Ppp1r14b
miRBase Accession/Entrez ID	MIMAT0000230	18938
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	AOM1//AOM172//P//PHI//PHI-1//PLC//PLCB3N//Png

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Ppp1r14b	chr19:6975255-6975256(+) m6A CDS       25412662//24981863//25569111 chr19:6975478-6975479(+) m6A CDS       25412662 chr19:6976581-6976582(+) m6A CDS       25412662 chr19:6976589-6976590(+) m6A CDS       25412662 chr19:6976880-6976881(+) m6A CDS       25412662//24981863 chr19:6977003-6977004(+) m6A CDS       25412662//24981863 chr19:6977084-6977085(+) m6A 3'UTR       25412662//24981863 chr19:6977128-6977129(+) m6A 3'UTR       25412662//24981863 chr19:6977236-6977237(+) m6A 3'UTR       24981863 chr19:6977245-6977246(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Ppp1r14b

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).