Basic Information:

  VIRBase ID:  

HHID00076281

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Lrp8:  NR_033496     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Lrp8
miRBase Accession/Entrez ID	MIMAT0000230	16975
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	4932703M08Rik//AA921429//AI848122//ap//ApoER2//Lr//Lr8b

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	Lrp8	chr4:107516897(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	Lrp8	chr4:107844292(+) A-I intron -    22524474

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Lrp8	chr4:107802342-107802343(+) m6A 5'UTR       25569111 chr4:107802957-107802958(+) m6A exon//intron       25683224//25412662//22608085 chr4:107803274-107803275(+) m6A CDS//exon       25683224//25412662//22608085 chr4:107803331-107803332(+) m6A CDS//exon       25683224//25412662//22608085 chr4:107803346-107803347(+) m6A CDS//exon       25683224//25412662//22608085 chr4:107823170-107823171(+) m6A exon//intron       25683224//25412662//22608085 chr4:107823216-107823217(+) m6A exon//intron       25683224//25412662 chr4:107830988-107830989(+) m6A CDS//exon//intron       25683224//25569111 chr4:107834634-107834635(+) m6A CDS//exon       25683224//25412662//25569111 chr4:107834644-107834645(+) m6A CDS//exon       25683224//25412662//25569111 chr4:107843252-107843253(+) m6A CDS//exon       25683224//24981863//25569111 chr4:107843305-107843306(+) m6A CDS//exon       25683224//25412662//24981863//25569111 chr4:107846349-107846350(+) m6A CDS//exon//intron       25412662//24981863 chr4:107846442-107846443(+) m6A CDS//exon//intron       25683224//25412662//24981863 chr4:107846489-107846490(+) m6A CDS//exon//intron       25683224//25412662//24981863 chr4:107846595-107846596(+) m6A CDS//exon//intron       25683224//25412662//24981863 chr4:107847450-107847451(+) m6A CDS//exon       25683224//25412662//24981863 chr4:107847487-107847488(+) m6A CDS//exon       25683224//25412662//24981863 chr4:107847527-107847528(+) m6A CDS//exon       25683224//25412662//24981863 chr4:107860063-107860064(+) m6A CDS//exon       24981863 chr4:107861179-107861180(+) m6A CDS//exon//intron       24981863 chr4:107861209-107861210(+) m6A CDS//exon//intron       24981863 chr4:107861237-107861238(+) m6A CDS//exon//intron       24981863 chr4:107861263-107861264(+) m6A CDS//exon//intron       24981863 chr4:107869022-107869023(+) m6A CDS//exon       24981863//22608085 chr4:107869037-107869038(+) m6A CDS//exon       24981863//22608085 chr4:107869120-107869121(+) m6A CDS//exon       24981863 chr4:107873040-107873041(+) m6A 3'UTR//intron       24981863 chr4:107873054-107873055(+) m6A 3'UTR//intron       24981863 chr4:107873087-107873088(+) m6A 3'UTR//intron       24981863//22608085 chr4:107873098-107873099(+) m6A 3'UTR//intron       24981863//22608085 chr4:107873112-107873113(+) m6A 3'UTR//intron       24981863//22608085 chr4:107873521-107873522(+) m6A 3'UTR//intron       24981863//22608085 chr4:107873728-107873729(+) m6A 3'UTR//intron       24981863 chr4:107873764-107873765(+) m6A 3'UTR//intron       24981863 chr4:107873886-107873887(+) m6A 3'UTR//intron       24981863 chr4:107874001-107874002(+) m6A 3'UTR//intron       25456834//24981863//25569111//22608085 chr4:107874113-107874114(+) m6A 3'UTR       25683224//25456834//24981863//25569111//26404942//22608085 chr4:107874151-107874152(+) m6A 3'UTR       25683224//25456834//24981863//25569111//26404942//22608085 chr4:107874266-107874267(+) m6A 3'UTR       24981863//25569111//22608085 chr4:107874277-107874278(+) m6A 3'UTR       24981863//25569111//22608085 chr4:107874448-107874449(+) m6A 3'UTR       24981863//25569111//26404942//22608085 chr4:107874460-107874461(+) m6A 3'UTR       24981863//25569111//26404942//22608085 chr4:107874613-107874614(+) m6A 3'UTR       24981863//25569111//26404942//22608085 chr4:107874643-107874644(+) m6A 3'UTR       24981863//25569111//26404942//22608085 chr4:107874681-107874682(+) m6A 3'UTR       24981863//25569111//26404942//22608085 chr4:107874781-107874782(+) m6A 3'UTR       24981863//25569111//26404942//22608085 chr4:107874830-107874831(+) m6A 3'UTR       25683224//24981863//25569111//26404942//22608085 chr4:107874835-107874836(+) m6A 3'UTR       25683224//24981863//25569111//26404942//22608085 chr4:107874859-107874860(+) m6A 3'UTR       25683224//24981863//25569111//26404942//22608085 chr4:107874892-107874893(+) m6A 3'UTR       25683224//24981863//25569111//26404942//22608085 chr4:107874950-107874951(+) m6A 3'UTR       25683224//24981863//25569111//26404942//22608085 chr4:107874962-107874963(+) m6A 3'UTR       25683224//24981863//25569111//26404942//22608085 chr4:107874971-107874972(+) m6A 3'UTR       25683224//24981863//25569111//26404942//22608085 chr4:107875031-107875032(+) m6A 3'UTR       25683224//24981863//25569111//26404942//22608085 chr4:107875050-107875051(+) m6A 3'UTR       25683224//24981863//25569111//26404942//22608085 chr4:107875062-107875063(+) m6A 3'UTR       25683224//24981863//25569111//26404942//22608085 chr4:107875129-107875130(+) m6A 3'UTR       25683224//24981863//25569111//26404942//22608085 chr4:107875136-107875137(+) m6A 3'UTR       25683224//25456834//24981863//25569111//26404942//22608085 chr4:107875187-107875188(+) m6A 3'UTR       25456834//24981863//25569111//26404942//22608085 chr4:107875228-107875229(+) m6A 3'UTR       25456834//24981863//25569111//22608085 chr4:107875239-107875240(+) m6A 3'UTR       25456834//24981863//25569111//22608085 chr4:107875253-107875254(+) m6A 3'UTR       25456834//24981863//25569111//22608085 chr4:107875337-107875338(+) m6A 3'UTR       24981863//25569111//22608085 chr4:107875375-107875376(+) m6A 3'UTR       24981863//25569111//26404942//22608085 chr4:107875436-107875437(+) m6A 3'UTR       24981863//25569111//26404942//22608085 chr4:107875529-107875530(+) m6A 3'UTR       25683224//25456834//24981863//25569111//26404942//22608085 chr4:107875579-107875580(+) m6A 3'UTR       25683224//25456834//24981863//25569111//26404942//22608085 chr4:107875615-107875616(+) m6A 3'UTR       25683224//25456834//24981863//25569111//26404942//22608085 chr4:107875645-107875646(+) m6A 3'UTR       25683224//25456834//24981863//25569111//26404942//22608085 chr4:107875672-107875673(+) m6A 3'UTR       25683224//25456834//24981863//25569111//26404942//22608085 chr4:107875685-107875686(+) m6A 3'UTR       25683224//25456834//24981863//25569111//26404942//22608085 chr4:107875734-107875735(+) m6A 3'UTR       25683224//24981863//25456834//25569111//26404942//22608085 chr4:107875779-107875780(+) m6A 3'UTR       25683224//24981863//25456834//25569111//26404942//22608085 chr4:107875829-107875830(+) m6A 3'UTR       25683224//24981863//25569111//22608085 chr4:107875972-107875973(+) m6A 3'UTR       25683224//24981863//26404942//22608085 chr4:107876050-107876051(+) m6A 3'UTR       25683224//24981863//25569111//26404942 chr4:107876112-107876113(+) m6A 3'UTR       24981863//25569111//26404942 chr4:107876333-107876334(+) m6A 3'UTR       24981863//26404942 chr4:107876346-107876347(+) m6A 3'UTR       24981863//26404942 chr4:107876412-107876413(+) m6A 3'UTR       24981863//26404942 chr4:107876441-107876442(+) m6A 3'UTR       24981863//26404942 chr4:107876447-107876448(+) m6A 3'UTR       24981863//26404942 chr4:107876460-107876461(+) m6A 3'UTR       24981863//26404942 chr4:107876469-107876470(+) m6A 3'UTR       24981863//26404942 chr4:107876536-107876537(+) m6A 3'UTR       24981863//26404942 chr4:107876548-107876549(+) m6A 3'UTR       24981863//26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862
	Lrp8	Nucleus Neuroblastoma cell line (N2A)     22406755 Nucleus Neuroblastoma cell line (N2A)     22406755

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Lrp8

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).