Basic Information:

  VIRBase ID:  

HHID00076275

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Kpnb1:  NM_008379     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Kpnb1
miRBase Accession/Entrez ID	MIMAT0000230	16211
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	AA409963//Im//Impnb//IPOB

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Kpnb1	chr11:97159796-97159797(-) m6A 3'UTR       25683224 chr11:97159806-97159807(-) m6A 3'UTR       25683224 chr11:97160144-97160145(-) m6A 3'UTR       24981863//22608085 chr11:97161609-97161610(-) m6A 3'UTR       24981863//22608085 chr11:97161616-97161617(-) m6A 3'UTR       24981863//22608085 chr11:97161648-97161649(-) m6A 3'UTR       24981863 chr11:97161670-97161671(-) m6A 3'UTR       24981863 chr11:97161719-97161720(-) m6A 3'UTR       24981863//25456834 chr11:97161753-97161754(-) m6A 3'UTR       24981863//25456834//25569111//22608085 chr11:97161774-97161775(-) m6A 3'UTR       24981863//25456834//25569111//22608085 chr11:97161783-97161784(-) m6A 3'UTR       24981863//25456834//25569111//22608085 chr11:97161840-97161841(-) m6A 3'UTR       24981863//25569111//22608085 chr11:97162060-97162061(-) m6A 3'UTR       24981863//22608085 chr11:97162089-97162090(-) m6A 3'UTR       24981863//22608085 chr11:97162322-97162323(-) m6A 3'UTR       24981863//25456834//25569111//22608085 chr11:97162377-97162378(-) m6A 3'UTR       24981863//25456834//25569111//22608085 chr11:97162411-97162412(-) m6A 3'UTR       25683224//25412662//24981863//25456834//25569111//22608085 chr11:97162427-97162428(-) Y 3'UTR//exon       26075521 chr11:97162437-97162438(-) m6A 3'UTR       25412662//24981863//25456834//25569111//22608085 chr11:97162445-97162446(-) m6A 3'UTR       25412662//24981863//25456834//25569111//22608085 chr11:97162467-97162468(-) m6A 3'UTR       25412662//24981863//25456834//25569111 chr11:97162500-97162501(-) m6A 3'UTR       25412662//24981863//25456834//25569111 chr11:97162548-97162549(-) m6A 3'UTR//exon       25412662//24981863//25569111 chr11:97162619-97162620(-) m6A 3'UTR//exon       25412662//24981863//25569111//22608085 chr11:97162651-97162652(-) m6A 3'UTR//exon       25412662//24981863//25569111//22608085 chr11:97163361-97163362(-) m6A CDS//exon       25412662//24981863//25569111//22608085 chr11:97163369-97163370(-) m6A CDS//exon       25412662//24981863//25569111//22608085 chr11:97163378-97163379(-) m6A CDS//exon       25412662//24981863//22608085 chr11:97163404-97163405(-) m6A CDS//exon       25412662//24981863//22608085 chr11:97163419-97163420(-) m6A CDS//exon       25412662//24981863//22608085 chr11:97163447-97163448(-) m6A CDS//exon       25412662//24981863//22608085 chr11:97163511-97163512(-) m6A CDS//exon       25412662//22608085 chr11:97173146-97173147(-) m6A CDS       22608085//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862
	Kpnb1	Axon Dorsal root ganglion     22841314 Nucleus Neuroblastoma cell line (N2A)     22406755

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Kpnb1

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).