Basic Information:

  VIRBase ID:  

HHID00076224

  Virus:  

Murid betaherpesvirus 1

  Host:  

Mus musculus

  Confidence Score:  

0.5711

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      mmu-miR-199a-3p:  MIMAT0000230          Ccng1:  NM_009831     

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Interactor Information:

	Interactor1	Interactor2
Symbol	mmu-miR-199a-3p	Ccng1
miRBase Accession/Entrez ID	MIMAT0000230	12450
Organism	Mus musculus	Mus musculus
Category	miRNA	mRNA
Alias	-	AI314029

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	Ccng1	chr11:40749471-40749472(-) m6A 3'UTR//exon       24981863//22608085 chr11:40749543-40749544(-) m6A 3'UTR//exon       24981863//26404942 chr11:40749550-40749551(-) m6A 3'UTR//exon       24981863//26404942 chr11:40749568-40749569(-) m6A 3'UTR//exon       25569111//26404942 chr11:40749643-40749644(-) m6A 3'UTR//intron       25569111//26404942 chr11:40749936-40749937(-) m6A 3'UTR//intron       24981863//22608085 chr11:40749965-40749966(-) m6A 3'UTR//intron       24981863//22608085 chr11:40750076-40750077(-) m6A 3'UTR//intron       24981863//22608085 chr11:40750086-40750087(-) m6A 3'UTR//intron       24981863//22608085 chr11:40750314-40750315(-) m6A 3'UTR//intron       24981863//25456834//25569111//26404942 chr11:40750367-40750368(-) m6A 3'UTR//intron       24981863//25456834//25569111//26404942 chr11:40750411-40750412(-) m6A 3'UTR//intron       24981863//25456834//25569111//26404942 chr11:40750424-40750425(-) m6A 3'UTR//intron       24981863//25456834//25569111//26404942 chr11:40750466-40750467(-) m6A 3'UTR//intron       25683224//24981863//25456834//25569111//26404942 chr11:40750493-40750494(-) m6A 3'UTR//intron       25683224//24981863//25569111 chr11:40750587-40750588(-) m6A 3'UTR//intron       25683224//24981863//25569111 chr11:40750652-40750653(-) m6A 3'UTR//intron       25683224//24981863 chr11:40750661-40750662(-) m6A 3'UTR//intron       25683224//24981863 chr11:40750753-40750754(-) m6A 3'UTR//intron       24981863//25569111 chr11:40750878-40750879(-) m6A CDS//intron       25412662//24981863//25569111 chr11:40750978-40750979(-) m6A CDS//intron       25412662//24981863//25569111//26404942 chr11:40750991-40750992(-) m6A CDS//intron       25412662//24981863//25569111//26404942 chr11:40751269-40751270(-) m6A CDS//intron       25569111 chr11:40751493-40751494(-) m6A CDS//intron       25569111//22608085 chr11:40752223-40752224(-) m6A CDS//exon       24981863//25569111//22608085 chr11:40752327-40752328(-) m6A CDS//exon       24981863//25569111//22608085 chr11:40753829-40753830(-) m6A CDS//exon       24981863//25569111//22608085 chr11:40753857-40753858(-) m6A CDS//exon       24981863//25569111//22608085 chr11:40753913-40753914(-) m6A CDS//exon       24981863//25569111//22608085 chr11:40753966-40753967(-) m6A CDS       24981863//25569111//22608085 chr11:40754005-40754006(-) m6A CDS       24981863//25569111//22608085 chr11:40754018-40754019(-) m6A CDS       24981863//25569111//22608085 chr11:40754035-40754036(-) m6A CDS       25569111//22608085 chr11:40755157-40755158(-) m6A 5'UTR       25412662//24981863//25569111 chr11:40755290-40755291(-) m6A 5'UTR       25683224//25412662//24981863//25569111 chr11:40755306-40755307(-) m6A 5'UTR       25683224//25412662//24981863//25569111

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	mmu-miR-199a-3p	Exosome Conditioned medium of E13 SMG     28041903 Exosome B6 BMDCs     22031862
	Ccng1	Exosome Mast cells     17486113 Nucleus Neuroblastoma cell line (N2A)     22406755

Interaction Network (The top 100 interactions):

Interactor1: mmu-miR-199a-3p
Interactor2: Ccng1

Evidence Support:

Weak-Evidence	MiRNA microarray
Prediction-Evidence	Targetscan
Support Database	ViRBase

References:

PMID	20643939	Target region	None
Source	ViRBase	Interactor1 expression	Upregulation
Tissue or cell line	NIH3T3 cells	Interactor2 expression	Downregulation
Description	All of the regulated genes in Fig. 5B are down-regulated by miR-199a-3p mimic and up-regulated by miR-199a-3p inhibitor compared with the negative transfection control, with the exception of ITGA6, which is only up-regulated by the inhibitor (Dataset S3).