Basic Information:

  VIRBase ID:  

HHID00076071

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-2-5p:  MIMAT0037312          TNKS2:  NM_025235     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-101-2-5p	TNKS2
miRBase Accession/Entrez ID	MIMAT0037312	80351
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARTD6//PARP-5b//PARP-5c//PARP5B//PARP5C//pART6//TANK2//TNKL

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-101-2-5p	rs1189997653 chr9:4850323    C/G rs1411860402 chr9:4850328    G/C rs1472339708 chr9:4850325    G/A rs374692878 chr9:4850308    T/C rs752365347 chr9:4850320    G/C rs758036961 chr9:4850324    C/T rs777507775 chr9:4850326    A/G rs570832031 chr9:4850310    G/A rs570832031 chr9:4850310    G/T rs766953168 chr9:4850309    C/T rs779213487 chr9:4850315    T/C rs894878476 chr9:4850314    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TNKS2	chr10:93608794(+) A-I      intronic chr10:93608828(+) A-I      intronic chr10:93582785(+) A-I      intronic chr10:93582780(+) A-I      intronic chr10:93563036(+) A-I      intronic chr10:93563118(+) A-I      intronic chr10:93563261(+) A-I      intronic chr10:93564593(+) A-I      intronic chr10:93564607(+) A-I      intronic chr10:93564660(+) A-I      intronic chr10:93564666(+) A-I      intronic chr10:93564781(+) A-I      intronic chr10:93564783(+) A-I      intronic chr10:93563122(+) A-I      intronic chr10:93567505(+) A-I      intronic chr10:93567532(+) A-I      intronic chr10:93569954(+) A-I      intronic chr10:93569955(+) A-I      intronic chr10:93582397(+) A-I      intronic chr10:93570464(+) A-I      intronic chr10:93570735(+) A-I      intronic chr10:93570764(+) A-I      intronic chr10:93570765(+) A-I      intronic chr10:93570799(+) A-I      intronic chr10:93571670(+) A-I      intronic chr10:93571675(+) A-I      intronic chr10:93571696(+) A-I      intronic chr10:93599284(+) A-I      intronic chr10:93578537(+) A-I      intronic chr10:93582387(+) A-I      intronic chr10:93582422(+) A-I      intronic chr10:93582695(+) A-I      intronic chr10:93582716(+) A-I      intronic chr10:93582719(+) A-I      intronic chr10:93582775(+) A-I      intronic chr10:93597457(+) A-I      intronic chr10:93598686(+) A-I      intronic chr10:93598809(+) A-I      intronic chr10:93599169(+) A-I      intronic chr10:93599820(+) A-I      intronic chr10:93599863(+) A-I      intronic chr10:93600022(+) A-I      intronic chr10:93600038(+) A-I      intronic chr10:93600042(+) A-I      intronic chr10:93600043(+) A-I      intronic chr10:93600047(+) A-I      intronic chr10:93600098(+) A-I      intronic chr10:93600114(+) A-I      intronic chr10:93610369(+) A-I      intronic chr10:93610417(+) A-I      intronic chr10:93600109(+) A-I      intronic chr10:93563165(+) A-I      intronic chr10:93563242(+) A-I      intronic chr10:93561452(+) A-I      intronic chr10:93599161(+) A-I      intronic chr10:93610433(+) A-I      intronic chr10:93599836(+) A-I      intronic chr10:93561490(+) A-I      intronic chr10:93570472(+) A-I      intronic chr10:93564588(+) A-I      intronic chr10:93569885(+) A-I      intronic chr10:93563114(+) A-I      intronic chr10:93610294(+) A-I      intronic chr10:93599843(+) A-I      intronic chr10:93570843(+) A-I      intronic chr10:93561420(+) A-I      intronic chr10:93597402(+) A-I      intronic chr10:93597452(+) A-I      intronic chr10:93561451(+) A-I      intronic chr10:93610387(+) A-I      intronic chr10:93563241(+) A-I      intronic chr10:93561300(+) A-I      intronic chr10:93610426(+) A-I      intronic chr10:93582423(+) A-I      intronic chr10:93569946(+) A-I      intronic chr10:93569972(+) A-I      intronic chr10:93614661(+) A-I      intronic chr10:93582749(+) A-I      intronic chr10:93599238(+) A-I      intronic chr10:93570848(+) A-I      intronic chr10:93609979(+) A-I      intronic chr10:93561357(+) A-I      intronic chr10:93599193(+) A-I      intronic chr10:93590158(+) A-I      intronic chr10:93598764(+) A-I      intronic chr10:93612037(+) A-I      intronic chr10:93598897(+) A-I      intronic chr10:93563279(+) A-I      intronic chr10:93570539(+) A-I      intronic chr10:93569923(+) A-I      intronic chr10:93570784(+) A-I      intronic chr10:93599232(+) A-I      intronic chr10:93609867(+) A-I      intronic chr10:93599269(+) A-I      intronic chr10:93561360(+) A-I      intronic chr10:93564600(+) A-I      intronic chr10:93609868(+) A-I      intronic chr10:93608777(+) A-I      intronic chr10:93612196(+) A-I      intronic chr10:93582760(+) A-I      intronic chr10:93563253(+) A-I      intronic chr10:93610329(+) A-I      intronic chr10:93608614(+) A-I      intronic chr10:93610325(+) A-I      intronic chr10:93570291(+) A-I      intronic chr10:93567497(+) A-I      intronic chr10:93597480(+) A-I      intronic chr10:93564704(+) A-I      intronic chr10:93608605(+) A-I      intronic chr10:93567632(+) A-I      intronic chr10:93563213(+) A-I      intronic chr10:93563012(+) A-I      intronic chr10:93599976(+) A-I      intronic chr10:93582424(+) A-I      intronic chr10:93614561(+) A-I      intronic chr10:93563190(+) A-I      intronic chr10:93582755(+) A-I      intronic chr10:93608697(+) A-I      intronic chr10:93582751(+) A-I      intronic chr10:93582690(+) A-I      intronic chr10:93567638(+) A-I      intronic chr10:93614513(+) A-I      intronic chr10:93569884(+) A-I      intronic chr10:93582402(+) A-I      intronic chr10:93582366(+) A-I      intronic chr10:93563061(+) A-I      intronic chr10:93578524(+) A-I      intronic chr10:93563315(+) A-I      intronic chr10:93590160(+) A-I      intronic chr10:93582689(+) A-I      intronic chr10:93570340(+) A-I      intronic chr10:93563116(+) A-I      intronic chr10:93609937(+) A-I      intronic chr10:93578504(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TNKS2	chr10:93611842(+) G-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TNKS2	chr10:93558208-93558209(+) m6A 5'UTR       24209618//25456834//24981863 chr10:93558300-93558301(+) m6A 5'UTR       24209618//25456834//24981863 chr10:93602097-93602098(+) Y CDS       26075521 chr10:93605672-93605673(+) m6A CDS       - chr10:93617204-93617205(+) m6A CDS       - chr10:93622772-93622773(+) m6A 3'UTR       26404942 chr10:93622786-93622787(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TNKS2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-101-2-5p
Interactor2: TNKS2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.