Basic Information:

  VIRBase ID:  

HHID00076022

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-2-5p:  MIMAT0037312          SACM1L:  NM_014016     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-101-2-5p	SACM1L
miRBase Accession/Entrez ID	MIMAT0037312	22908
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	SAC1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-101-2-5p	rs1189997653 chr9:4850323    C/G rs1411860402 chr9:4850328    G/C rs1472339708 chr9:4850325    G/A rs374692878 chr9:4850308    T/C rs752365347 chr9:4850320    G/C rs758036961 chr9:4850324    C/T rs777507775 chr9:4850326    A/G rs570832031 chr9:4850310    G/A rs570832031 chr9:4850310    G/T rs766953168 chr9:4850309    C/T rs779213487 chr9:4850315    T/C rs894878476 chr9:4850314    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SACM1L	chr3:45742400(+) A-I      intronic chr3:45753816(+) A-I      intronic chr3:45753936(+) A-I      intronic chr3:45775690(+) A-I      intronic chr3:45775747(+) A-I      intronic chr3:45775992(+) A-I      intronic chr3:45775749(+) A-I      intronic chr3:45775752(+) A-I      intronic chr3:45775798(+) A-I      intronic chr3:45776048(+) A-I      intronic chr3:45775816(+) A-I      intronic chr3:45775685(+) A-I      intronic chr3:45753000(+) A-I      intronic chr3:45754002(+) A-I      intronic chr3:45775753(+) A-I      intronic chr3:45757164(+) A-I      intronic chr3:45776080(+) A-I      intronic chr3:45752973(+) A-I      intronic chr3:45775855(+) A-I      intronic chr3:45776016(+) A-I      intronic chr3:45752974(+) A-I      intronic chr3:45776035(+) A-I      intronic chr3:45753921(+) A-I      intronic chr3:45775826(+) A-I      intronic chr3:45753067(+) A-I      intronic chr3:45775667(+) A-I      intronic chr3:45775929(+) A-I      intronic chr3:45753868(+) A-I      intronic chr3:45775695(+) A-I      intronic chr3:45775744(+) A-I      intronic chr3:45775743(+) A-I      intronic chr3:45753867(+) A-I      intronic chr3:45775758(+) A-I      intronic chr3:45776013(+) A-I      intronic chr3:45775811(+) A-I      intronic chr3:45753883(+) A-I      intronic chr3:45753877(+) A-I      intronic chr3:45775988(+) A-I      intronic chr3:45752847(+) A-I      intronic chr3:45775928(+) A-I      intronic chr3:45752917(+) A-I      intronic chr3:45775865(+) A-I      intronic chr3:45753962(+) A-I      intronic chr3:45775785(+) A-I      intronic chr3:45776078(+) A-I      intronic chr3:45752877(+) A-I      intronic chr3:45776066(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SACM1L	chr3:45776172(+) A-I intron -    21960545 chr3:45785026(+) T-G intron -    21725310 chr3:45738551(+) A-G intron -    22484847 chr3:45738558(+) A-G intron -    22484847 chr3:45753868(+) A-G intron -    22484847 chr3:45753877(+) A-G intron -    22484847 chr3:45753962(+) A-G intron -    22484847 chr3:45757164(+) A-G intron -    22484847 chr3:45775695(+) A-G intron -    22484847 chr3:45775703(+) A-G intron -    22484847 chr3:45775744(+) A-G intron -    22484847 chr3:45775745(+) A-G intron -    22484847 chr3:45776049(+) A-G intron -    22484847 chr3:45776078(+) A-G intron -    22484847 chr3:45776080(+) A-G intron -    22484847 chr3:45776146(+) A-G intron -    22484847 chr3:45776172(+) A-G intron -    22484847 chr3:45776175(+) A-G intron -    22484847 chr3:45776189(+) A-G intron -    22484847 chr3:45776197(+) A-G intron -    22484847 chr3:45776211(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SACM1L	chr3:45785035-45785036(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr3:45785041-45785042(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr3:45785083-45785084(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr3:45785133-45785134(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//22608085 chr3:45785156-45785157(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//22608085 chr3:45785210-45785211(+) m6A 3'UTR//exon       24284625//24981863//26404942//22608085 chr3:45786654-45786655(+) m6A 3'UTR//exon       27773535 chr3:45786714-45786715(+) m6A 3'UTR//exon       26404942//27773535 chr3:45786740-45786741(+) m6A 3'UTR//exon       26404942//27773535 chr3:45786751-45786752(+) m6A 3'UTR//exon       26404942//27773535 chr3:45786782-45786783(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SACM1L	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Urine     25135963 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-101-2-5p
Interactor2: SACM1L

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.