Basic Information:

  VIRBase ID:  

HHID00075999

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-101-2-5p:  MIMAT0037312          VDAC3:  NM_001135694     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-101-2-5p	VDAC3
miRBase Accession/Entrez ID	MIMAT0037312	7419
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HD-VDAC3//VDAC-3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-101-2-5p	rs1189997653 chr9:4850323    C/G rs1411860402 chr9:4850328    G/C rs1472339708 chr9:4850325    G/A rs374692878 chr9:4850308    T/C rs752365347 chr9:4850320    G/C rs758036961 chr9:4850324    C/T rs777507775 chr9:4850326    A/G rs570832031 chr9:4850310    G/A rs570832031 chr9:4850310    G/T rs766953168 chr9:4850309    C/T rs779213487 chr9:4850315    T/C rs894878476 chr9:4850314    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	VDAC3	chr8:42258310(+) A-I      intronic chr8:42253311(+) A-I      intronic chr8:42253315(+) A-I      intronic chr8:42257735(+) A-I      intronic chr8:42257776(+) A-I      intronic chr8:42258736(+) A-I      intronic chr8:42258808(+) A-I      intronic chr8:42258815(+) A-I      intronic chr8:42258844(+) A-I      intronic chr8:42258876(+) A-I      intronic chr8:42258898(+) A-I      intronic chr8:42258900(+) A-I      intronic chr8:42258901(+) A-I      intronic chr8:42258987(+) A-I      intronic chr8:42253292(+) A-I      intronic chr8:42257601(+) A-I      intronic chr8:42262169(+) A-I      intronic chr8:42253480(+) A-I      intronic chr8:42258253(+) A-I      intronic chr8:42258375(+) A-I      intronic chr8:42255929(+) A-I      intronic chr8:42255822(+) A-I      intronic chr8:42258443(+) A-I      intronic chr8:42257699(+) A-I      intronic chr8:42258915(+) A-I      intronic chr8:42253332(+) A-I      intronic chr8:42253405(+) A-I      intronic chr8:42253397(+) A-I      intronic chr8:42257781(+) A-I      intronic chr8:42255854(+) A-I      intronic chr8:42255967(+) A-I      intronic chr8:42261203(+) A-I      intronic chr8:42255911(+) A-I      intronic chr8:42258384(+) A-I      intronic chr8:42257713(+) A-I      intronic chr8:42255884(+) A-I      intronic chr8:42255910(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	VDAC3	chr8:42257699(+) A-G intron -    22484847 chr8:42257713(+) A-G intron -    22484847 chr8:42258443(+) A-G intron -    22484847 chr8:42258915(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	VDAC3	chr8:42249398-42249399(+) m6A 5'UTR       24981863 chr8:42249427-42249428(+) m6A 5'UTR//exon       24981863 chr8:42256289-42256290(+) m6A 3'UTR//CDS//exon       27773535 chr8:42256315-42256316(+) m6A 3'UTR//CDS//exon       27773535 chr8:42256338-42256339(+) m6A 3'UTR//CDS//exon       27773535 chr8:42256344-42256345(+) m6A 3'UTR//CDS//exon       27773535 chr8:42256358-42256359(+) m6A 3'UTR//CDS//exon       27773535 chr8:42257083-42257084(+) m6A exon//intron       27773535 chr8:42257092-42257093(+) m6A exon//intron       27773535 chr8:42262927-42262928(+) m6A CDS//exon//intron       24284625//27773535 chr8:42262967-42262968(+) m6A CDS       24284625//24981863//27773535 chr8:42263030-42263031(+) m6A 3'UTR       24284625//24981863//26404942//27773535 chr8:42263081-42263082(+) m6A 3'UTR       24284625//24981863//26404942//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	VDAC3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-101-2-5p
Interactor2: VDAC3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.