Basic Information:

  VIRBase ID:  

HHID00075434

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-328-5p:  MIMAT0026486          ZNF330:  NM_001292002     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-328-5p	ZNF330
miRBase Accession/Entrez ID	MIMAT0026486	27309
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HSA6591//NOA36

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-328-5p	rs1390800622 chr16:67202369    C/T rs1396185071 chr16:67202368    C/T rs1457737368 chr16:67202371    G/A rs188892061 chr16:67202389    C/A rs188892061 chr16:67202389    C/G rs188892061 chr16:67202389    C/T rs1319752585 chr16:67202381    TG/T rs1486950888 chr16:67202388    C/A rs755480131 chr16:67202383    C/A rs755480131 chr16:67202383    C/T rs765423113 chr16:67202384    C/A rs765423113 chr16:67202384    C/T rs776111360 chr16:67202382    G/GC

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZNF330	chr4:142143540-142143541(+) m6A CDS//exon       24981863//27773535 chr4:142143565-142143566(+) m6A CDS//exon       24981863//27773535 chr4:142143584-142143585(+) m6A CDS//exon       24981863//27773535 chr4:142143623-142143624(+) m6A CDS//exon       24981863//27773535 chr4:142143683-142143684(+) m6A exon//intron       - chr4:142153734-142153735(+) m6A 3'UTR//CDS       - chr4:142153765-142153766(+) m6A 3'UTR//CDS       - chr4:142153774-142153775(+) m6A 3'UTR//CDS       - chr4:142153781-142153782(+) m6A 3'UTR//CDS       - chr4:142154894-142154895(+) m6A 3'UTR//CDS       27773535 chr4:142154946-142154947(+) m6A 3'UTR//CDS       24981863//27773535 chr4:142155098-142155099(+) m6A 3'UTR//CDS       24209618//24981863//27773535//22608085 chr4:142155130-142155131(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:142155138-142155139(+) m6A 3'UTR//CDS       24284625//24209618//24981863//27773535//22608085 chr4:142155253-142155254(+) m6A 3'UTR       24284625//24209618//24981863//27773535 chr4:142155302-142155303(+) m6A 3'UTR       24981863//27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-328-5p	Exosome Serum     18589210 Exosome Peripheral blood mononuclear cells     19002258 Exosome Renal cancer cells     21670082 Exosome Brain tissue     23382797 Exosome Plasma     23663360 Exosome Breast cancer cell lines (MCF-7|MDA-MB-231)     24468161 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Extracellular vesicle HEK-293T cells     22849433 Microvesicle Seminal plasma     23539611 Microvesicle Fibroblasts|Mesenchymal stem cells     - Mitochondrion HeLa cells     27396686 Mitochondrion HeLa cells     27563705 Mitochondrion Skeletal muscle myoblasts     21637849 Mitochondrion Cell line (HeLa)     21695135
	ZNF330	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-328-5p
Interactor2: ZNF330

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.