Detail Information

Basic Information:


  VIRBase ID:  

HHID00075282

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-365b-3p:           TMTC3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-365b-3p TMTC3
miRBase
Accession/Entrez ID		 MIMAT0022834 160418
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - LIS8//SMILE

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-365b-3p
rs1183474028 chr17:31575492    A/G
rs1411099672 chr17:31575494    C/T
rs35143473 chr17:31575498    AT/A
rs745712604 chr17:31575499    T/C
rs781117282 chr17:31575484    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TMTC3
chr12:88557908(+) A-I      intronic
chr12:88557899(+) A-I      intronic
chr12:88556882(+) A-I      intronic
chr12:88556709(+) A-I      intronic
chr12:88556895(+) A-I      intronic
chr12:88557711(+) A-I      intronic
chr12:88556711(+) A-I      intronic
chr12:88557812(+) A-I      intronic
chr12:88557916(+) A-I      intronic
chr12:88556779(+) A-I      intronic
chr12:88556757(+) A-I      intronic
chr12:88556749(+) A-I      intronic
chr12:88557734(+) A-I      intronic
chr12:88585561(+) A-I      intronic
chr12:88557814(+) A-I      intronic
chr12:88552842(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED TMTC3
chr12:88557814(+) A-G intron -    22484847
chr12:88556749(+) A-G intron -    22484847
chr12:88556757(+) A-G intron -    22484847
chr12:88556779(+) A-G intron -    22484847
chr12:88557734(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TMTC3
chr12:88536086-88536087(+) m6A 5'UTR       25456834//24981863
chr12:88536116-88536117(+) m6A 5'UTR       25456834//24981863
chr12:88536155-88536156(+) m6A 5'UTR       25456834//24981863
chr12:88536177-88536178(+) m6A 5'UTR//intron       25456834//24981863
chr12:88586407-88586408(+) m6A CDS       24981863//26404942
chr12:88586451-88586452(+) m6A CDS       24284625//24981863//26404942//22608085
chr12:88586500-88586501(+) m6A CDS       24284625//24981863//26404942//22608085
chr12:88586509-88586510(+) m6A CDS       24284625//24981863//26404942//22608085
chr12:88586529-88586530(+) m6A CDS       24284625//24981863//26404942//22608085
chr12:88586548-88586549(+) m6A CDS       24284625//24981863//26404942//22608085
chr12:88586566-88586567(+) m6A CDS       24284625//24981863//26404942//22608085
chr12:88588624-88588625(+) m6A CDS       24284625//24981863//26404942//22608085
chr12:88588630-88588631(+) m6A CDS       24284625//24981863//26404942//22608085
chr12:88588731-88588732(+) m6A CDS       24284625//24209618//24981863//26404942//22575960//22608085
chr12:88588823-88588824(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr12:88588911-88588912(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr12:88589002-88589003(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085
chr12:88589037-88589038(+) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr12:88589069-88589070(+) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr12:88589242-88589243(+) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr12:88589261-88589262(+) m6A CDS       24284625//24981863//27773535//22575960//22608085
chr12:88589296-88589297(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr12:88589324-88589325(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr12:88589336-88589337(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr12:88589346-88589347(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr12:88589389-88589390(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr12:88589459-88589460(+) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr12:88589577-88589578(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085
chr12:88589765-88589766(+) m6A 3'UTR       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-365b-3p
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Exosome Colon cancer cell line (LIM1863)     25330373
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
TMTC3
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function
ncDR hsa-miR-365b-3p
2-(2,4-Difluorophenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione 9905583 Drug resistant
S-Decyl p-toluenethiosulfonate 97461 Drug resistant
Ethyl phenylpropiolate 91516 Drug resistant
[(1R,2S,6R,7R,9S,12S,13S)-13-(Acetyloxymethyl)-12-hydroxy-9-methyl-5-methylidene-4-oxo-3,14-dioxatricyclo[7.4.1.02,6]tetradecan-7-yl] (Z)-2-(acetyloxymethyl)but-2-enoate 90473692 Drug resistant
Jacaranone 73307 Drug resistant
Morpholine-N-dithiocarbamate 72675 Drug resistant
7-Hydroxystaurosporine 72271 Drug resistant
Sulbentine 67686 Drug resistant
Reactive Blue 2 656725 Drug resistant
(2S)-N-[(E,2S,4S,7S)-7-[[(2R)-2-Aminopropanoyl]amino]-4-formyl-5-(3-hydroxy-4-methoxyphenyl)-2-[[(Z)-3-(4-methoxyphenyl)-2-(methylamino)prop-2-enoyl]amino]-3,6,10-trioxodec-8-en-4-yl]-3-(4-hydroxyphenyl)-N-methyl-2-(methylamino)propanamide 6444175 Drug resistant
Liatris laevigata lactone #2 5477810 Drug resistant
p-Chloranilinum[bis(p-chloraniline)dioxalatoruthenate(III)] 54608061 Drug resistant
Antineoplastic-651590 54604785 Drug resistant
Stereoisomer of 672120 (MW=262) 5459262 Drug resistant
Thiram 5455 Drug resistant
(E)-1-(2,5-Dihydroxyphenyl)ethene-2-isonitrile 5388136 Drug resistant
Acetylrolandrolide 5384465 Drug resistant
Ovatifolin acetate 5358419 Drug resistant
3-[1-(2-Chlorophenyl)ethoxy]-5-(6-methoxybenzimidazol-1-yl)thiophene-2-carboxamide 53338698 Drug resistant
5-[6-[(1-Methylpiperidin-4-yl)methoxy]benzimidazol-1-yl]-3-[1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide 53338689 Drug resistant
Herbimycin 5311102 Drug resistant
Cyclosporin A 5284373 Drug resistant
Erioflorin acetate 5281443 Drug resistant
Lychnopholide 49767028 Drug resistant
Tiazofurin 457954 Drug resistant
Kalamycin 443836 Drug resistant
Elephantin 442205 Drug resistant
2,6-Epoxy-2H-1-benzoxocin-5(6H)-one, 6,8-dimethyl- 434882 Drug resistant
Physalolactone 433866 Drug resistant
Oridonin (thiol adduct OF) 432952 Drug resistant
10-Hydroxy-5-methoxy-1-(2-methyloxiran-2-yl)-1,2-dihydrofuro[2,3-c]xanthen-6-one 429905 Drug resistant
S-(Diisopropylarsino)-3-mercapto-1,2-propanediol 406478 Drug resistant
11-Hydroxyusambarine Chlorhydrate 401426 Drug resistant
Triacetyl crambescidin 800 hydrochloride 400721 Drug resistant
3-[(2-Bromoacetyl)amino]-N-carbamoylbenzamide 398525 Drug resistant
7-Epi-3,4-bis-nor-dolastatin 11 396354 Drug resistant
2-Amino-4-(2-hydroxy-4-methylphenyl)-5-phenylpyrimidine 392744 Drug resistant
15-Oxozoapatlin 391317 Drug resistant
Stereoisomer of NSC 674066-O 384359 Drug resistant
2-Amino-5,8-dihydroxy-1,4-naphthoquinone 377209 Drug resistant
3,8-Dimethyl-1,2-naphthoquinone 373912 Drug resistant
N-Hydroxy-N-methylpropanethioamide 371713 Drug resistant
11H-Benzo[a]carbazole-1,4-dione, 7,11-dimethyl- 371271 Drug resistant
Benzoxazole, 2-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]- 364608 Drug resistant
4-Nitro-6-(trifluoromethyl)-2,1,3-benzoselenadiazole 362897 Drug resistant
Discorhabdin C . TFA 362393 Drug resistant
Bis(helenalinyl)glutarate 336831 Drug resistant
4-Selenazolecarboxamide, 2-beta-D-ribofuranosyl- 334706 Drug resistant
Dmask 32465 Drug resistant
8-Trichloromethyldihydroberberine 320713 Drug resistant
2,3-Dimethoxy-5-naphthalen-2-ylsulfanylcyclohexa-2,5-diene-1,4-dione 314728 Drug resistant
1,4-Naphthalenedione, 5,8-dihydroxy-2,3-bis(hydroxymethyl)- 313371 Drug resistant
Stannane, trimethyl[(4-morpholinylthioxomethyl)thio]- 300936 Drug resistant
2,3-Bis(iodomethyl)-6-methoxyquinoxaline 286257 Drug resistant
Dichloroallyl lawsone 277767 Drug resistant
1H-Benzo[a]carbazole-1,4(11H)-dione, 11-methyl- 261066 Drug resistant
3-[(1R)-1-(2-Chlorophenyl)ethoxy]-5-{6-[(2S)-2,3-dihydroxypropoxy]-1H-1,3-benzodiazol-1-yl}thiophene-2-carboxamide 25263120 Drug resistant
(2-Methoxy-9,10-dihydrophenanthren-3-yl)methyl-dimethyl-(phenylsulfanylmethyl)azanium;bromide 24200489 Drug resistant
[(4E,6Z,10Z)-20,22-Dihydroxy-13,14,17-trimethoxy-4,8,10,12,16-pentamethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18(22),19-hexaen-9-yl] carbamate 24199492 Drug resistant
7-Fluoro-2-benzoyl-3-trifluoromethylquioxaline 1,4-dioxide 23635154 Drug resistant
2,4,6-Trichloro-5-methylpyrimidine 232789 Drug resistant
(1S,3R,7Z,9R,12S,13R,15R)-13-Hydroxy-3,7,12-trimethyl-13-prop-1-en-2-yl-10,14,16-trioxatetracyclo[7.5.1.13,6.012,15]hexadeca-5,7-diene-4,11-dione 20835084 Drug resistant
4-Chloro-5-phenoxy-3H-1,2-dithiole-3-thione 16766044 Drug resistant
Trihexyltetradecylphosphonium hexafluorophosphate 16212610 Drug resistant
(3As,3bR)-3b-hydroxy-3a,5,5-trimethyl-3-methylidene-4H-cyclopenta[a]pentalene-2,6-dione 15699597 Drug resistant
(6R)-1,6,11-Trihydroxy-8-[(2S,4R,5R,6R)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-[(2S,5S,6S)-5-[(2S,4R,5R,6R)-4-hydroxy-5-[(2S,4R,5R,6R)-5-hydroxy-4-[(2S,5S,6S)-5-hydroxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-3-methyl-5,6-dihydrobenzo[a]anthracene-7,12-dione 15507920 Drug resistant
Methyl 3,4-dichloro-5-nitro-2-furoate 147711 Drug resistant
1H-2,10a-Ethanophenanthrene, kaur-16-en-15-one deriv. 146156727 Drug resistant
Gold;(2S,3R,4S,5R,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphanium 138402869 Drug resistant
Methyl ester prodigiosene 136040158 Drug resistant
Discorhabdin B 135409044 Drug resistant
2-Chloro-3-(2-butoxyethoxy)naphthazarin 135406263 Drug resistant
Dibutyltin dichloride 12688 Drug resistant
Melampodinin 11953936 Drug resistant
Acetylenedicarboxamide 10971 Drug resistant
Erigerol 101318126 Drug resistant
(1s,2e,4r,7e,11e)-4-hydroxy-2,7,11-cembratrien-6-one - Drug resistant
(1s,2e,4s,6r,7e,10r,11e)-2,7,11-cembratriene-4,6,10-triol - Drug resistant
(E)-2-(2-(benzo[d][1,3]dioxol-5-yl)vinyl)-5-(3-methyl-1H-pyrazol-5-yl)-1,3,4-oxadiazole - Drug resistant
1,1'-biphenyl, 4,4'bis(thiomethyl)- - Drug resistant
1-piperidinecarbodithioic acid, antimony complex - Drug resistant
2-[(3,4-dicloro)anilino]-3-phenyl-5,7-diamino quinoxaline - Drug resistant
2-acetyl-9-methoxy-1,2-dihydroellipticine - Drug resistant
2-propen-1-one, 3-(2-hydroxyphenyl)-1-phenyl- (9ci) - Drug resistant
3,19-(4-n,n-dimethylamino)benzylidineandrographolide - Drug resistant
3,19-benzylidine-14-deoxy-11,12-didehydroandrographolide - Drug resistant
4-(2-pyridinyl)-5h-1,2,3-dithiazole-5-thione - Drug resistant
4-morpholinecarbodithioic acid, antimony complex - Drug resistant
4-piperidinone, 3,5-bis[(4-fluorophenyl)methylene]-, (e,e)- - Drug resistant
4-thiomorpholinecarbodithioic acid, antimony complex - Drug resistant
5-[2-(4-methoxyphenyl)ethyl]-1,2,3-dimethoxy benzene - Drug resistant
7-n,n-dimethylamino brefeldin a hydrochloride - Drug resistant
b676297k277 3',4'-deoxypsorospermin 3',4'-chlorohydrin - Drug resistant
cyclopentanone, 2,5-bis[(trimethylamino)methyl]-, iodide - Drug resistant
dimethylarsinothious acid, 2,4-pyrimidinediyl ester - Drug resistant
ethyl, methoxy, prodigisine - Drug resistant
iodonium, (4-methoxyphenyl)(3-methylphenyl)-, bromide - Drug resistant
phosphonium, (3-bromopropyl)triphenyl- bromide - Drug resistant
phosphonium, 1,8-octanediylbis[triphenyl-, diiodide - Drug resistant
pyrimidine, 2,4,5-trichloro-6-ethyl- - Drug resistant
pyrimidine, 2,4,5-trichloro-6-isopropyl- - Drug resistant
pyrimidine, 2,4,5-trichloro-6-propyl- - Drug resistant
uridine, 5-isobutyl-2'-deoxy- - Drug resistant
(Z)-6-chloro-3-((2-(4-methoxyphenyl)-3H-benzo[d]imidazol-5-yl)methylene)indolin-2-one - Drug resistant
2'-deoxy-2'-methoxycarbonylmethylidine-uridine - Drug resistant
9-(3-fluorobenzyl)-7-(3-fluorobenzyloxy)-2-(4-fluorobenzyl)-1-methyl-9H-beta-carbolinium bromide - Drug resistant
antineoplastic-624657 - Drug resistant
chlorambucil-spermidine - Drug resistant
Copper(II) complex with quin as a ligand - Drug resistant
discorhabdin g - Drug resistant
euchrysine - Drug resistant
his 47-methyl ct - Drug resistant
maleimide carbazole - Drug resistant
n-acetyl-4-s-cystaminyl phenol - Drug resistant
pancratium littorale - Drug resistant
streptorubrin - Drug resistant
thiadiazines - Drug resistant
Uniroyal Compound-38 - Drug resistant
6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione - Drug sensitive
antineoplastic-d655481 - Drug sensitive
geldanamycin dimethylglycinate - Drug sensitive
Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-365b-3p
Doxorubicin 31703 Drug interaction    RC00008620

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-365b-3p
Interactor2: TMTC3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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