Basic Information:

  VIRBase ID:  

HHID00074802

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.9973

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-203b-3p:  MIMAT0019814          CCNG1:  NR_157055     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-203b-3p	CCNG1
miRBase Accession/Entrez ID	MIMAT0019814	900
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CCNG

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-203b-3p	rs527418519 chr14:104117439    T/C rs771545143 chr14:104117431    A/G rs1307766631 chr14:104117443    C/G rs1444131167 chr14:104117448    C/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CCNG1	chr5:162873961(+) A-I      3'UTR chr5:162873874(+) A-I      3'UTR chr5:162873835(+) A-I      3'UTR chr5:162873787(+) A-I      3'UTR chr5:162865794(+) A-I      intronic chr5:162875046(+) A-I      3'UTR chr5:162873759(+) A-I      3'UTR chr5:162873927(+) A-I      3'UTR chr5:162874256(+) A-I      3'UTR chr5:162873766(+) A-I      3'UTR chr5:162875073(+) A-I      3'UTR chr5:162873801(+) A-I      3'UTR chr5:162874367(+) A-I      3'UTR chr5:162873915(+) A-I      3'UTR chr5:162874420(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CCNG1	chr5:162865794(+) A-G intron -    22484847 chr5:162865937(+) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CCNG1	chr5:162864671-162864672(+) m6A 5'UTR//exon//intron       24981863 chr5:162870699-162870700(+) m6A 3'UTR//CDS//exon       24981863//22608085 chr5:162870779-162870780(+) m6A 3'UTR//exon       24981863//26404942//22608085 chr5:162870808-162870809(+) m6A 3'UTR//exon       24981863//26404942//22608085 chr5:162870818-162870819(+) m6A 3'UTR//exon       24981863//26404942//22608085 chr5:162871185-162871186(+) m6A 3'UTR//intron       24981863//27773535 chr5:162871227-162871228(+) m6A 3'UTR//intron       24981863//27773535 chr5:162871290-162871291(+) m6A 3'UTR//intron       24981863 chr5:162871467-162871468(+) m6A 3'UTR//exon       24981863 chr5:162871497-162871498(+) m6A 3'UTR//exon//intron       24981863 chr5:162871507-162871508(+) m6A 3'UTR//exon//intron       24981863 chr5:162871531-162871532(+) m6A 3'UTR//exon//intron       24981863 chr5:162871607-162871608(+) m6A 3'UTR//exon//intron       26404942 chr5:162871827-162871828(+) m6A 3'UTR//exon//intron       27773535 chr5:162871859-162871860(+) m6A 3'UTR//exon//intron       27773535 chr5:162871955-162871956(+) m6A 3'UTR//exon//intron       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-203b-3p	Exosome Plasma     23663360 Exosome Colon cancer cell line (LIM1863)     25330373 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)     -
	CCNG1	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome-free cytosol Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-203b-3p
Interactor2: CCNG1

Evidence Support:

Strong-Evidence	IHC//ISH//Luciferase reporter assay//RT-PCR//Western blot
Weak-Evidence	Microarray
Prediction-Evidence	PicTar//Targetscan
Support Database	ViRBase

References:

PMID	22205737	Target region	3'UTR
Source	ViRBase	Interactor1 expression	Downregulation
Tissue or cell line	293-EBV cells//6-10B cells	Interactor2 expression	None
Description	EBV-LMP1 mediated the downregulation of miR-203 at the primary transcript level. E2F3 and CCNG1 were identified as target genes of miR-203.Overexpression of the targets overcame the effects of miR-203 mimics on the cell cycle, and the expression of target genes in tumor models was inhibited by miR-203.