Basic Information:

  VIRBase ID:  

HHID00074470

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3916:  MIMAT0018190          TFG:  NM_001195479     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3916	TFG
miRBase Accession/Entrez ID	MIMAT0018190	10342
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HMSNP//SPG57//TF6//TRKT3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3916	rs1476085878 chr1:247202033    C/T rs979335578 chr1:247202024    C/A rs534993102 chr1:247202035    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TFG	chr3:100433283(+) A-I      intronic chr3:100446748(+) A-I      intronic chr3:100433224(+) A-I      intronic chr3:100433231(+) A-I      intronic chr3:100433225(+) A-I      intronic chr3:100433194(+) A-I      intronic chr3:100432798(+) A-I      intronic chr3:100432788(+) A-I      intronic chr3:100446806(+) A-I      intronic chr3:100433251(+) A-I      intronic chr3:100433265(+) A-I      intronic chr3:100440852(+) A-I      intronic chr3:100443767(+) A-I      intronic chr3:100443957(+) A-I      intronic chr3:100444367(+) A-I      intronic chr3:100444437(+) A-I      intronic chr3:100444523(+) A-I      intronic chr3:100444024(+) A-I      intronic chr3:100443817(+) A-I      intronic chr3:100444391(+) A-I      intronic chr3:100444558(+) A-I      intronic chr3:100444518(+) A-I      intronic chr3:100443822(+) A-I      intronic chr3:100432819(+) A-I      intronic chr3:100443877(+) A-I      intronic chr3:100432814(+) A-I      intronic chr3:100440858(+) A-I      intronic chr3:100450478(+) A-I      intronic chr3:100450501(+) A-I      intronic chr3:100443860(+) A-I      intronic chr3:100444519(+) A-I      intronic chr3:100444502(+) A-I      intronic chr3:100444403(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TFG	chr3:100432814(+) A-G intron -    22484847 chr3:100432819(+) A-G intron -    22484847 chr3:100433080(+) A-G intron -    22484847 chr3:100433088(+) A-G intron -    22484847 chr3:100433244(+) A-C intron -    22484847 chr3:100440816(+) A-G intron -    22484847 chr3:100440858(+) A-G intron -    22484847 chr3:100443817(+) A-G intron -    22484847 chr3:100443822(+) A-G intron -    22484847 chr3:100443860(+) A-G intron -    22484847 chr3:100443877(+) A-G intron -    22484847 chr3:100443887(+) A-G intron -    22484847 chr3:100443932(+) A-G intron -    22484847 chr3:100444391(+) A-G intron -    22484847 chr3:100444403(+) A-G intron -    22484847 chr3:100444520(+) T-C intron -    22484847 chr3:100458749(+) T-C intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TFG	chr3:100428208-100428209(+) m6A 5'UTR       24981863 chr3:100428231-100428232(+) m6A 5'UTR       24981863 chr3:100428308-100428309(+) m6A 5'UTR//intron       24981863 chr3:100428527-100428528(+) m6A 5'UTR//intron       24981863//22575960 chr3:100428618-100428619(+) m6A 5'UTR//intron       24981863 chr3:100432512-100432513(+) m6A 5'UTR       26404942 chr3:100432537-100432538(+) m6A CDS       26404942 chr3:100451453-100451454(+) m6A CDS       27773535 chr3:100455454-100455455(+) m6A CDS       27773535 chr3:100455538-100455539(+) m6A CDS       24981863//26404942//27773535 chr3:100461353-100461354(+) m6A exon//intron       24284625//24981863 chr3:100461423-100461424(+) m6A exon//intron       24284625 chr3:100463635-100463636(+) m6A exon//intron       24981863 chr3:100467009-100467010(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr3:100467014-100467015(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr3:100467153-100467154(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//27773535 chr3:100467168-100467169(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//27773535 chr3:100467251-100467252(+) m6A 3'UTR//CDS//exon       24284625//24981863//26404942//27773535 chr3:100467359-100467360(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535 chr3:100467428-100467429(+) m6A 3'UTR//exon       24284625//24981863//26404942//27773535 chr3:100467533-100467534(+) m6A 3'UTR//exon       26404942//27773535 chr3:100467541-100467542(+) m6A 3'UTR//exon       26404942//27773535 chr3:100467602-100467603(+) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3916	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Urine     -
	TFG	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3916
Interactor2: TFG

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.