Basic Information:

  VIRBase ID:  

HHID00074112

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3681-5p:  MIMAT0018108          CPEB2:  NM_182646     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3681-5p	CPEB2
miRBase Accession/Entrez ID	MIMAT0018108	132864
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CPE-BP2//CPEB-2//hCPEB-2

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3681-5p	rs1040681310 chr2:12199152    C/T rs1045647749 chr2:12199156    G/C rs1448564652 chr2:12199149    G/A rs773395905 chr2:12199142    G/A rs944609352 chr2:12199145    T/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CPEB2	chr4:15038777(+) A-I      intronic chr4:15038780(+) A-I      intronic chr4:15038766(+) A-I      intronic chr4:15038767(+) A-I      intronic chr4:15038671(+) A-I      intronic chr4:15040465(+) A-I      intronic chr4:15040313(+) A-I      intronic chr4:15040415(+) A-I      intronic chr4:15012914(+) A-I      intronic chr4:15038919(+) A-I      intronic chr4:15038672(+) A-I      intronic chr4:15040312(+) A-I      intronic chr4:15040342(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CPEB2	chr4:15004327-15004328(+) m6A CDS       - chr4:15004570-15004571(+) m6A CDS       24981863 chr4:15004647-15004648(+) m6A CDS       24284625//24981863 chr4:15004712-15004713(+) m6A CDS       24284625//24981863 chr4:15004719-15004720(+) m6A CDS       24284625//24981863 chr4:15004790-15004791(+) m6A CDS       24284625//24209618//24981863 chr4:15004871-15004872(+) m6A CDS       24284625//24981863 chr4:15005039-15005040(+) m6A CDS       22575960 chr4:15005066-15005067(+) m6A CDS       22575960 chr4:15005149-15005150(+) m6A CDS       22575960 chr4:15005219-15005220(+) m6A CDS       24284625 chr4:15067999-15068000(+) m6A CDS       24284625//24981863//22608085 chr4:15068013-15068014(+) m6A 3'UTR       24284625//24981863//22608085 chr4:15068151-15068152(+) m6A 3'UTR       24284625 chr4:15068180-15068181(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3681-5p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Fibroblasts|Mesenchymal stem cells     -
	CPEB2	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3681-5p
Interactor2: CPEB2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.