Basic Information:

  VIRBase ID:  

HHID00073938

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3678-3p:  MIMAT0018103          NUP188:  NM_015354     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3678-3p	NUP188
miRBase Accession/Entrez ID	MIMAT0018103	23511
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	hNup188//KIAA0169//SANDSTEF

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3678-3p	rs1163369708 chr17:75406153    G/A rs1174219930 chr17:75406155    C/G rs1273558782 chr17:75406157    G/A rs1424776090 chr17:75406150    A/T rs1475188526 chr17:75406151    C/T rs755095016 chr17:75406158    G/T rs915488824 chr17:75406156    C/A rs915488824 chr17:75406156    C/T rs988363493 chr17:75406137    C/T rs753118178 chr17:75406141    A/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NUP188	chr9:131714603(+) A-I      intronic chr9:131711777(+) A-I      intronic chr9:131711753(+) A-I      intronic chr9:131711738(+) A-I      intronic chr9:131711705(+) A-I      intronic chr9:131711691(+) A-I      intronic chr9:131766394(+) A-I      intronic chr9:131724193(+) A-I      intronic chr9:131724645(+) A-I      intronic chr9:131724653(+) A-I      intronic chr9:131724657(+) A-I      intronic chr9:131724775(+) A-I      intronic chr9:131726213(+) A-I      intronic chr9:131726225(+) A-I      intronic chr9:131727921(+) A-I      intronic chr9:131729524(+) A-I      intronic chr9:131737156(+) A-I      intronic chr9:131737769(+) A-I      intronic chr9:131738716(+) A-I      intronic chr9:131766403(+) A-I      intronic chr9:131723489(+) A-I      intronic chr9:131738740(+) A-I      intronic chr9:131738749(+) A-I      intronic chr9:131738803(+) A-I      intronic chr9:131738811(+) A-I      intronic chr9:131738819(+) A-I      intronic chr9:131738829(+) A-I      intronic chr9:131723488(+) A-I      intronic chr9:131739134(+) A-I      intronic chr9:131739203(+) A-I      intronic chr9:131739210(+) A-I      intronic chr9:131739855(+) A-I      intronic chr9:131723109(+) A-I      intronic chr9:131739888(+) A-I      intronic chr9:131739955(+) A-I      intronic chr9:131739957(+) A-I      intronic chr9:131723108(+) A-I      intronic chr9:131722974(+) A-I      intronic chr9:131723994(+) A-I      intronic chr9:131722611(+) A-I      intronic chr9:131722548(+) A-I      intronic chr9:131714165(+) A-I      intronic chr9:131722417(+) A-I      intronic chr9:131722394(+) A-I      intronic chr9:131722374(+) A-I      intronic chr9:131722008(+) A-I      intronic chr9:131722006(+) A-I      intronic chr9:131721929(+) A-I      intronic chr9:131721912(+) A-I      intronic chr9:131721911(+) A-I      intronic chr9:131739989(+) A-I      intronic chr9:131740041(+) A-I      intronic chr9:131740655(+) A-I      intronic chr9:131740812(+) A-I      intronic chr9:131741106(+) A-I      intronic chr9:131743771(+) A-I      intronic chr9:131743792(+) A-I      intronic chr9:131751049(+) A-I      intronic chr9:131721898(+) A-I      intronic chr9:131753937(+) A-I      intronic chr9:131721873(+) A-I      intronic chr9:131753945(+) A-I      intronic chr9:131753960(+) A-I      intronic chr9:131753971(+) A-I      intronic chr9:131751056(+) A-I      intronic chr9:131751132(+) A-I      intronic chr9:131751142(+) A-I      intronic chr9:131751449(+) A-I      intronic chr9:131751725(+) A-I      intronic chr9:131751782(+) A-I      intronic chr9:131752985(+) A-I      intronic chr9:131753008(+) A-I      intronic chr9:131739963(+) A-I      intronic chr9:131753972(+) A-I      intronic chr9:131754001(+) A-I      intronic chr9:131766368(+) A-I      intronic chr9:131753033(+) A-I      intronic chr9:131753050(+) A-I      intronic chr9:131753079(+) A-I      intronic chr9:131753151(+) A-I      intronic chr9:131753587(+) A-I      intronic chr9:131753607(+) A-I      intronic chr9:131753621(+) A-I      intronic chr9:131753667(+) A-I      intronic chr9:131753767(+) A-I      intronic chr9:131753967(+) A-I      intronic chr9:131751988(+) A-I      intronic chr9:131712919(+) A-I      intronic chr9:131712842(+) A-I      intronic chr9:131753968(+) A-I      intronic chr9:131753969(+) A-I      intronic chr9:131754024(+) A-I      intronic chr9:131754261(+) A-I      intronic chr9:131754267(+) A-I      intronic chr9:131754338(+) A-I      intronic chr9:131754451(+) A-I      intronic chr9:131762835(+) A-I      intronic chr9:131763130(+) A-I      intronic chr9:131763160(+) A-I      intronic chr9:131763167(+) A-I      intronic chr9:131763170(+) A-I      intronic chr9:131763223(+) A-I      intronic chr9:131712225(+) A-I      intronic chr9:131711778(+) A-I      intronic chr9:131721868(+) A-I      intronic chr9:131766409(+) A-I      intronic chr9:131719800(+) A-I      intronic chr9:131719787(+) A-I      intronic chr9:131753023(+) A-I      intronic chr9:131729404(+) A-I      intronic chr9:131751061(+) A-I      intronic chr9:131754565(+) A-I      intronic chr9:131738940(+) A-I      intronic chr9:131713476(+) A-I      intronic chr9:131752752(+) A-I      intronic chr9:131751641(+) A-I      intronic chr9:131751493(+) A-I      intronic chr9:131739811(+) A-I      intronic chr9:131712639(+) A-I      intronic chr9:131721886(+) A-I      intronic chr9:131722573(+) A-I      intronic chr9:131739094(+) A-I      intronic chr9:131714172(+) A-I      intronic chr9:131739817(+) A-I      intronic chr9:131752014(+) A-I      intronic chr9:131729356(+) A-I      intronic chr9:131753970(+) A-I      intronic chr9:131751135(+) A-I      intronic chr9:131712762(+) A-I      intronic chr9:131741118(+) A-I      intronic chr9:131751601(+) A-I      intronic chr9:131751491(+) A-I      intronic chr9:131751573(+) A-I      intronic chr9:131714881(+) A-I      intronic chr9:131751858(+) A-I      intronic chr9:131738718(+) A-I      intronic chr9:131762715(+) A-I      intronic chr9:131751145(+) A-I      intronic chr9:131739122(+) A-I      intronic chr9:131754517(+) A-I      intronic chr9:131729373(+) A-I      intronic chr9:131711170(+) A-I      intronic chr9:131739179(+) A-I      intronic chr9:131766323(+) A-I      intronic chr9:131751217(+) A-I      intronic chr9:131751295(+) A-I      intronic chr9:131735787(+) A-I      intronic chr9:131754611(+) A-I      intronic chr9:131712901(+) A-I      intronic chr9:131741170(+) A-I      intronic chr9:131753557(+) A-I      intronic chr9:131763196(+) A-I      intronic chr9:131766990(+) A-I      intronic chr9:131730336(+) A-I      intronic chr9:131752889(+) A-I      intronic chr9:131751454(+) A-I      intronic chr9:131712341(+) A-I      intronic chr9:131740067(+) A-I      intronic chr9:131754455(+) A-I      intronic chr9:131729503(+) A-I      intronic chr9:131754509(+) A-I      intronic chr9:131753964(+) A-I      intronic chr9:131744123(+) A-I      intronic chr9:131751243(+) A-I      intronic chr9:131730160(+) A-I      intronic chr9:131722957(+) A-I      intronic chr9:131754664(+) A-I      intronic chr9:131739958(+) A-I      intronic chr9:131751224(+) A-I      intronic chr9:131751992(+) A-I      intronic chr9:131753975(+) A-I      intronic chr9:131712942(+) A-I      intronic chr9:131754633(+) A-I      intronic chr9:131713527(+) A-I      intronic chr9:131751831(+) A-I      intronic chr9:131735845(+) A-I      intronic chr9:131766369(+) A-I      intronic chr9:131754709(+) A-I      intronic chr9:131729709(+) A-I      intronic chr9:131751961(+) A-I      intronic chr9:131763079(+) A-I      intronic chr9:131724919(+) A-I      intronic chr9:131751106(+) A-I      intronic chr9:131752751(+) A-I      intronic chr9:131711872(+) A-I      intronic chr9:131712524(+) A-I      intronic chr9:131754589(+) A-I      intronic chr9:131724318(+) A-I      intronic chr9:131762727(+) A-I      intronic chr9:131723639(+) A-I      intronic chr9:131714245(+) A-I      intronic chr9:131723243(+) A-I      intronic chr9:131752888(+) A-I      intronic chr9:131723050(+) A-I      intronic chr9:131751268(+) A-I      intronic chr9:131729523(+) A-I      intronic chr9:131751418(+) A-I      intronic chr9:131753034(+) A-I      intronic chr9:131738154(+) A-I      intronic chr9:131711634(+) A-I      intronic chr9:131711692(+) A-I      intronic chr9:131753705(+) A-I      intronic chr9:131753652(+) A-I      intronic chr9:131723680(+) A-I      intronic chr9:131737708(+) A-I      intronic chr9:131763206(+) A-I      intronic chr9:131760269(+) A-I      intronic chr9:131712977(+) A-I      intronic chr9:131712616(+) A-I      intronic chr9:131763286(+) A-I      intronic chr9:131752636(+) A-I      intronic chr9:131730613(+) A-I      intronic chr9:131754449(+) A-I      intronic chr9:131728789(+) A-I      intronic chr9:131729733(+) A-I      intronic chr9:131729372(+) A-I      intronic chr9:131714189(+) A-I      intronic chr9:131743766(+) A-I      intronic chr9:131738799(+) A-I      intronic chr9:131754373(+) A-I      intronic chr9:131723202(+) A-I      intronic chr9:131763242(+) A-I      intronic chr9:131722551(+) A-I      intronic chr9:131722624(+) A-I      intronic chr9:131719974(+) A-I      intronic chr9:131711751(+) A-I      intronic chr9:131762871(+) A-I      intronic chr9:131754597(+) A-I      intronic chr9:131751105(+) A-I      intronic chr9:131712864(+) A-I      intronic chr9:131723635(+) A-I      intronic chr9:131766284(+) A-I      intronic chr9:131751110(+) A-I      intronic chr9:131753692(+) A-I      intronic chr9:131739951(+) A-I      intronic chr9:131721881(+) A-I      intronic chr9:131739839(+) A-I      intronic chr9:131723670(+) A-I      intronic chr9:131739997(+) A-I      intronic chr9:131724735(+) A-I      intronic chr9:131738285(+) A-I      intronic chr9:131723019(+) A-I      intronic chr9:131712981(+) A-I      intronic chr9:131741155(+) A-I      intronic chr9:131711988(+) A-I      intronic chr9:131713017(+) A-I      intronic chr9:131763281(+) A-I      intronic chr9:131741089(+) A-I      intronic chr9:131754674(+) A-I      intronic chr9:131737938(+) A-I      intronic chr9:131762773(+) A-I      intronic chr9:131753590(+) A-I      intronic chr9:131754726(+) A-I      intronic chr9:131730173(+) A-I      intronic chr9:131762782(+) A-I      intronic chr9:131730175(+) A-I      intronic chr9:131712319(+) A-I      intronic chr9:131751569(+) A-I      intronic chr9:131723732(+) A-I      intronic chr9:131751234(+) A-I      intronic chr9:131751693(+) A-I      intronic chr9:131744276(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NUP188	chr9:131751569(+) A-I intron -    22327324 chr9:131751573(+) A-I intron -    22327324 chr9:131712938(+) A-G intron -    22484847 chr9:131713003(+) A-G intron -    22484847 chr9:131713017(+) A-G intron -    22484847 chr9:131723462(+) A-G intron -    22484847 chr9:131744466(+) T-C intron -    22484847 chr9:131751110(+) A-G intron -    22484847 chr9:131751135(+) A-G intron -    22484847 chr9:131751494(+) A-G intron -    22484847 chr9:131751533(+) A-G intron -    22484847 chr9:131751569(+) A-G intron -    22484847 chr9:131751573(+) A-G intron -    22484847 chr9:131751601(+) A-G intron -    22484847 chr9:131752014(+) A-G intron -    22484847 chr9:131753639(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NUP188	chr9:131710866-131710867(+) m6A exon//intron       - chr9:131711479-131711480(+) m6A CDS//exon       24284625//24209618//24981863//22608085 chr9:131711486-131711487(+) m6A CDS//exon       24284625//24209618//24981863//22608085 chr9:131715068-131715069(+) m6A CDS//exon       24284625//24209618//24981863 chr9:131715077-131715078(+) m6A CDS//exon       24284625//24209618//24981863 chr9:131715116-131715117(+) m6A CDS//exon       24284625//24209618 chr9:131721353-131721354(+) Cm CDS       - chr9:131730983-131730984(+) Tm CDS       - chr9:131749123-131749124(+) m6A CDS//exon       - chr9:131749137-131749138(+) m6A CDS//exon       - chr9:131749924-131749925(+) m6A CDS//exon       - chr9:131749959-131749960(+) m6A CDS//exon       - chr9:131755945-131755946(+) m6A CDS//exon       22575960 chr9:131755968-131755969(+) m6A CDS//exon       22575960 chr9:131762022-131762023(+) m6A CDS//exon       24284625//22575960 chr9:131762028-131762029(+) m6A CDS//exon       24284625//22575960 chr9:131762039-131762040(+) m6A CDS//exon       24284625//22575960 chr9:131762070-131762071(+) m6A CDS//exon       24284625//22575960 chr9:131763949-131763950(+) m6A CDS//exon       24284625 chr9:131765185-131765186(+) m6A CDS//exon       22575960 chr9:131766241-131766242(+) m6A exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3678-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	NUP188	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3678-3p
Interactor2: NUP188

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.