Basic Information:

  VIRBase ID:  

HHID00073873

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3662:  MIMAT0018083          C18orf25:  NM_145055     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3662	C18orf25
miRBase Accession/Entrez ID	MIMAT0018083	147339
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Ark2N//ARKL1//RNF111L1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3662	rs1269591251 chr6:134979367    C/T rs1392974872 chr6:134979361    T/C rs779534942 chr6:134979360    G/A rs748588809 chr6:134979372    C/A rs748588809 chr6:134979372    C/T rs763349803 chr6:134979371    TC/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	C18orf25	chr18:43846560(+) A-I      3'UTR chr18:43764216(+) A-I      intronic chr18:43764217(+) A-I      intronic chr18:43764218(+) A-I      intronic chr18:43764271(+) A-I      intronic chr18:43764270(+) A-I      intronic chr18:43761106(+) A-I      intronic chr18:43825159(+) A-I      intronic chr18:43825372(+) A-I      intronic chr18:43832048(+) A-I      intronic chr18:43832039(+) A-I      intronic chr18:43831949(+) A-I      intronic chr18:43829221(+) A-I      intronic chr18:43829215(+) A-I      intronic chr18:43827755(+) A-I      intronic chr18:43760459(+) A-I      intronic chr18:43760497(+) A-I      intronic chr18:43791357(+) A-I      intronic chr18:43760525(+) A-I      intronic chr18:43760561(+) A-I      intronic chr18:43760565(+) A-I      intronic chr18:43761035(+) A-I      intronic chr18:43761045(+) A-I      intronic chr18:43761061(+) A-I      intronic chr18:43761064(+) A-I      intronic chr18:43768495(+) A-I      intronic chr18:43761167(+) A-I      intronic chr18:43761771(+) A-I      intronic chr18:43761848(+) A-I      intronic chr18:43762475(+) A-I      intronic chr18:43762527(+) A-I      intronic chr18:43764122(+) A-I      intronic chr18:43764255(+) A-I      intronic chr18:43764433(+) A-I      intronic chr18:43765720(+) A-I      intronic chr18:43765743(+) A-I      intronic chr18:43765806(+) A-I      intronic chr18:43765832(+) A-I      intronic chr18:43765874(+) A-I      intronic chr18:43766187(+) A-I      intronic chr18:43766255(+) A-I      intronic chr18:43766345(+) A-I      intronic chr18:43766600(+) A-I      intronic chr18:43826827(+) A-I      intronic chr18:43768551(+) A-I      intronic chr18:43768559(+) A-I      intronic chr18:43772290(+) A-I      intronic chr18:43772633(+) A-I      intronic chr18:43772733(+) A-I      intronic chr18:43772736(+) A-I      intronic chr18:43772885(+) A-I      intronic chr18:43772938(+) A-I      intronic chr18:43772953(+) A-I      intronic chr18:43773030(+) A-I      intronic chr18:43778694(+) A-I      intronic chr18:43782657(+) A-I      intronic chr18:43786194(+) A-I      intronic chr18:43758733(+) A-I      intronic chr18:43758749(+) A-I      intronic chr18:43756978(+) A-I      intronic chr18:43756882(+) A-I      intronic chr18:43788461(+) A-I      intronic chr18:43788484(+) A-I      intronic chr18:43756490(+) A-I      intronic chr18:43757250(+) A-I      intronic chr18:43790680(+) A-I      intronic chr18:43790715(+) A-I      intronic chr18:43790716(+) A-I      intronic chr18:43757497(+) A-I      intronic chr18:43827737(+) A-I      intronic chr18:43757524(+) A-I      intronic chr18:43757784(+) A-I      intronic chr18:43758284(+) A-I      intronic chr18:43758726(+) A-I      intronic chr18:43758759(+) A-I      intronic chr18:43758783(+) A-I      intronic chr18:43759050(+) A-I      intronic chr18:43759672(+) A-I      intronic chr18:43759731(+) A-I      intronic chr18:43759774(+) A-I      intronic chr18:43759829(+) A-I      intronic chr18:43795038(+) A-I      intronic chr18:43795075(+) A-I      intronic chr18:43799476(+) A-I      intronic chr18:43799562(+) A-I      intronic chr18:43800838(+) A-I      intronic chr18:43800906(+) A-I      intronic chr18:43800944(+) A-I      intronic chr18:43826708(+) A-I      intronic chr18:43800949(+) A-I      intronic chr18:43801265(+) A-I      intronic chr18:43801316(+) A-I      intronic chr18:43801326(+) A-I      intronic chr18:43810125(+) A-I      intronic chr18:43801328(+) A-I      intronic chr18:43801454(+) A-I      intronic chr18:43801491(+) A-I      intronic chr18:43808583(+) A-I      intronic chr18:43808757(+) A-I      intronic chr18:43809498(+) A-I      intronic chr18:43809504(+) A-I      intronic chr18:43809521(+) A-I      intronic chr18:43809949(+) A-I      intronic chr18:43760453(+) A-I      intronic chr18:43810143(+) A-I      intronic chr18:43821839(+) A-I      intronic chr18:43821852(+) A-I      intronic chr18:43821922(+) A-I      intronic chr18:43822049(+) A-I      intronic chr18:43824589(+) A-I      intronic chr18:43824672(+) A-I      intronic chr18:43824685(+) A-I      intronic chr18:43824835(+) A-I      intronic chr18:43824836(+) A-I      intronic chr18:43824847(+) A-I      intronic chr18:43824960(+) A-I      intronic chr18:43825025(+) A-I      intronic chr18:43825070(+) A-I      intronic chr18:43801256(+) A-I      intronic chr18:43801411(+) A-I      intronic chr18:43757848(+) A-I      intronic chr18:43799565(+) A-I      intronic chr18:43768925(+) A-I      intronic chr18:43766301(+) A-I      intronic chr18:43778066(+) A-I      intronic chr18:43825443(+) A-I      intronic chr18:43800940(+) A-I      intronic chr18:43769034(+) A-I      intronic chr18:43757754(+) A-I      intronic chr18:43775804(+) A-I      intronic chr18:43782724(+) A-I      intronic chr18:43827874(+) A-I      intronic chr18:43769477(+) A-I      intronic chr18:43773312(+) A-I      intronic chr18:43800959(+) A-I      intronic chr18:43757478(+) A-I      intronic chr18:43778010(+) A-I      intronic chr18:43782592(+) A-I      intronic chr18:43825346(+) A-I      intronic chr18:43768961(+) A-I      intronic chr18:43757523(+) A-I      intronic chr18:43758989(+) A-I      intronic chr18:43781978(+) A-I      intronic chr18:43800926(+) A-I      intronic chr18:43778146(+) A-I      intronic chr18:43789821(+) A-I      intronic chr18:43772667(+) A-I      intronic chr18:43768550(+) A-I      intronic chr18:43799697(+) A-I      intronic chr18:43824919(+) A-I      intronic chr18:43807644(+) A-I      intronic chr18:43826752(+) A-I      intronic chr18:43762441(+) A-I      intronic chr18:43832012(+) A-I      intronic chr18:43790755(+) A-I      intronic chr18:43800915(+) A-I      intronic chr18:43765766(+) A-I      intronic chr18:43761809(+) A-I      intronic chr18:43769004(+) A-I      intronic chr18:43783654(+) A-I      intronic chr18:43799647(+) A-I      intronic chr18:43821980(+) A-I      intronic chr18:43826760(+) A-I      intronic chr18:43764630(+) A-I      intronic chr18:43825494(+) A-I      intronic chr18:43782589(+) A-I      intronic chr18:43769509(+) A-I      intronic chr18:43762509(+) A-I      intronic chr18:43825384(+) A-I      intronic chr18:43825336(+) A-I      intronic chr18:43801257(+) A-I      intronic chr18:43772362(+) A-I      intronic chr18:43808798(+) A-I      intronic chr18:43772956(+) A-I      intronic chr18:43801302(+) A-I      intronic chr18:43764653(+) A-I      intronic chr18:43826699(+) A-I      intronic chr18:43764252(+) A-I      intronic chr18:43768492(+) A-I      intronic chr18:43775030(+) A-I      intronic chr18:43763923(+) A-I      intronic chr18:43768587(+) A-I      intronic chr18:43801022(+) A-I      intronic chr18:43772284(+) A-I      intronic chr18:43781918(+) A-I      intronic chr18:43825416(+) A-I      intronic chr18:43757808(+) A-I      intronic chr18:43769521(+) A-I      intronic chr18:43774823(+) A-I      intronic chr18:43808772(+) A-I      intronic chr18:43764651(+) A-I      intronic chr18:43827859(+) A-I      intronic chr18:43769655(+) A-I      intronic chr18:43757532(+) A-I      intronic chr18:43825095(+) A-I      intronic chr18:43807706(+) A-I      intronic chr18:43782734(+) A-I      intronic chr18:43826787(+) A-I      intronic chr18:43768547(+) A-I      intronic chr18:43825160(+) A-I      intronic chr18:43782558(+) A-I      intronic chr18:43759093(+) A-I      intronic chr18:43765898(+) A-I      intronic chr18:43801405(+) A-I      intronic chr18:43764506(+) A-I      intronic chr18:43782578(+) A-I      intronic chr18:43767168(+) A-I      intronic chr18:43764512(+) A-I      intronic chr18:43801481(+) A-I      intronic chr18:43800978(+) A-I      intronic chr18:43816241(+) A-I      intronic chr18:43760959(+) A-I      intronic chr18:43791346(+) A-I      intronic chr18:43764511(+) A-I      intronic chr18:43806903(+) A-I      intronic chr18:43757834(+) A-I      intronic chr18:43801034(+) A-I      intronic chr18:43781954(+) A-I      intronic chr18:43766342(+) A-I      intronic chr18:43825433(+) A-I      intronic chr18:43790816(+) A-I      intronic chr18:43758728(+) A-I      intronic chr18:43765767(+) A-I      intronic chr18:43835433(+) A-I      intronic chr18:43800892(+) A-I      intronic chr18:43809798(+) A-I      intronic chr18:43764410(+) A-I      intronic chr18:43757451(+) A-I      intronic chr18:43764057(+) A-I      intronic chr18:43800931(+) A-I      intronic chr18:43799635(+) A-I      intronic chr18:43808709(+) A-I      intronic chr18:43768574(+) A-I      intronic chr18:43757721(+) A-I      intronic chr18:43782686(+) A-I      intronic chr18:43759796(+) A-I      intronic chr18:43805638(+) A-I      intronic chr18:43789834(+) A-I      intronic chr18:43825078(+) A-I      intronic chr18:43765846(+) A-I      intronic chr18:43764585(+) A-I      intronic chr18:43768723(+) A-I      intronic chr18:43811825(+) A-I      intronic chr18:43758725(+) A-I      intronic chr18:43832322(+) A-I      intronic chr18:43795138(+) A-I      intronic chr18:43774192(+) A-I      intronic chr18:43799709(+) A-I      intronic chr18:43824707(+) A-I      intronic chr18:43758751(+) A-I      intronic chr18:43778068(+) A-I      intronic chr18:43807664(+) A-I      intronic chr18:43769101(+) A-I      intronic chr18:43778639(+) A-I      intronic chr18:43764538(+) A-I      intronic chr18:43774702(+) A-I      intronic chr18:43757498(+) A-I      intronic chr18:43827847(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	C18orf25	chr18:43799709(+) A-I intron -    22327324 chr18:43772284(+) A-G intron -    22484847 chr18:43772285(+) A-G intron -    22484847 chr18:43775804(+) A-G intron -    22484847 chr18:43790755(+) A-G intron -    22484847 chr18:43799565(+) A-G intron -    22484847 chr18:43799709(+) A-G intron -    22484847 chr18:43801411(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	C18orf25	chr18:43753641-43753642(+) m6A 5'UTR       24981863//22608085 chr18:43754065-43754066(+) m6A 5'UTR//exon//intron       24981863 chr18:43795813-43795814(+) m6A 5'UTR//exon//intron       24209618//24981863//22608085 chr18:43795881-43795882(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22608085 chr18:43795917-43795918(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr18:43795924-43795925(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr18:43795953-43795954(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr18:43796028-43796029(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:43796039-43796040(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr18:43796193-43796194(+) m6A 5'UTR//CDS//exon       24981863//22608085 chr18:43796225-43796226(+) m6A 5'UTR//CDS//exon       22575960//22608085 chr18:43796290-43796291(+) m6A 5'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr18:43796315-43796316(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr18:43796334-43796335(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr18:43796453-43796454(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr18:43796539-43796540(+) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr18:43796579-43796580(+) m6A exon//intron       - chr18:43796657-43796658(+) m6A exon//intron       - chr18:43796683-43796684(+) m6A exon//intron       - chr18:43796702-43796703(+) m6A exon//intron       - chr18:43796720-43796721(+) m6A exon//intron       - chr18:43796743-43796744(+) m6A exon//intron       - chr18:43796763-43796764(+) m6A exon//intron       - chr18:43796789-43796790(+) m6A exon//intron       - chr18:43819974-43819975(+) m6A CDS//intron       24284625//24209618//24981863//27773535//22608085 chr18:43833777-43833778(+) m6A CDS       27773535//22608085 chr18:43842976-43842977(+) m6A CDS       24284625//24209618//24981863//22608085 chr18:43842988-43842989(+) m6A CDS       24284625//24209618//24981863//22608085 chr18:43843009-43843010(+) m6A CDS       24284625//24209618//24981863//22608085 chr18:43846631-43846632(+) m6A 3'UTR       24981863 chr18:43846683-43846684(+) m6A 3'UTR       24981863 chr18:43846752-43846753(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3662	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	C18orf25	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3662
Interactor2: C18orf25

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.