Basic Information:

  VIRBase ID:  

HHID00073870

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3662:  MIMAT0018083          UPRT:  NR_030774     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3662	UPRT
miRBase Accession/Entrez ID	MIMAT0018083	139596
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	FUR1//UPP

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3662	rs1269591251 chr6:134979367    C/T rs1392974872 chr6:134979361    T/C rs779534942 chr6:134979360    G/A rs748588809 chr6:134979372    C/A rs748588809 chr6:134979372    C/T rs763349803 chr6:134979371    TC/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	UPRT	chrX:74522424(+) A-I      intronic chrX:74522485(+) A-I      intronic chrX:74522343(+) A-I      intronic chrX:74522474(+) A-I      intronic chrX:74522481(+) A-I      intronic chrX:74522490(+) A-I      intronic chrX:74522435(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	UPRT	chrX:74493936-74493937(+) m6A 5'UTR//exon       24981863 chrX:74493962-74493963(+) m6A 5'UTR//exon       24981863 chrX:74494114-74494115(+) m6A CDS//exon       24284625//24209618//22608085 chrX:74494144-74494145(+) m6A CDS//exon       24284625//24209618//22608085 chrX:74494198-74494199(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chrX:74494213-74494214(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chrX:74494282-74494283(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22608085 chrX:74494384-74494385(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chrX:74494391-74494392(+) m6A CDS//exon       24284625//25456834//24981863//22608085 chrX:74494401-74494402(+) Cm CDS//exon       - chrX:74519582-74519583(+) m6A 3'UTR//CDS//exon       24981863 chrX:74519596-74519597(+) m6A 3'UTR//CDS//exon       24981863 chrX:74519689-74519690(+) m6A 3'UTR//CDS//exon       24209618 chrX:74523321-74523322(+) m6A 3'UTR//CDS//exon       24981863 chrX:74523935-74523936(+) m6A 3'UTR       - chrX:74524009-74524010(+) m6A 3'UTR       - chrX:74524035-74524036(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3662	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	UPRT	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3662
Interactor2: UPRT

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.