Basic Information:

  VIRBase ID:  

HHID00073866

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3662:  MIMAT0018083          PRRC1:  NM_130809     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3662	PRRC1
miRBase Accession/Entrez ID	MIMAT0018083	133619
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3662	rs1269591251 chr6:134979367    C/T rs1392974872 chr6:134979361    T/C rs779534942 chr6:134979360    G/A rs748588809 chr6:134979372    C/A rs748588809 chr6:134979372    C/T rs763349803 chr6:134979371    TC/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PRRC1	chr5:126864087(+) A-I      intronic chr5:126863413(+) A-I      intronic chr5:126863260(+) A-I      intronic chr5:126863305(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PRRC1	chr5:126853346-126853347(+) m6A 5'UTR//exon       24284625//24981863 chr5:126859195-126859196(+) m6A CDS//exon       24284625//24209618//24981863 chr5:126859210-126859211(+) m6A CDS//exon       24284625//24209618//24981863 chr5:126859371-126859372(+) m6A exon//intron       24284625 chr5:126859787-126859788(+) m6A exon//intron       24284625//24209618//24981863 chr5:126860471-126860472(+) m6A CDS       24981863 chr5:126862365-126862366(+) m6A CDS       26404942 chr5:126862371-126862372(+) m6A CDS       26404942 chr5:126862408-126862409(+) m6A CDS       26404942 chr5:126862418-126862419(+) Y CDS       26075521 chr5:126869429-126869430(+) m6A CDS       24981863 chr5:126883653-126883654(+) m6A CDS//intron       24284625 chr5:126887420-126887421(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr5:126887497-126887498(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:126887580-126887581(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:126887599-126887600(+) m6A 3'UTR//CDS//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:126887614-126887615(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:126887627-126887628(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:126887633-126887634(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr5:126887777-126887778(+) m6A 3'UTR//exon//intron       26404942 chr5:126887787-126887788(+) m6A 3'UTR//exon//intron       26404942 chr5:126890573-126890574(+) m6A 3'UTR       27773535 chr5:126890578-126890579(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3662	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	PRRC1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3662
Interactor2: PRRC1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.