Basic Information:

  VIRBase ID:  

HHID00073849

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3662:  MIMAT0018083          GFM1:  NM_024996     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3662	GFM1
miRBase Accession/Entrez ID	MIMAT0018083	85476
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	COXPD1//EFG//EFG1//EFGM//EGF1//GFM//hEFG1//mtEF-G1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3662	rs1269591251 chr6:134979367    C/T rs1392974872 chr6:134979361    T/C rs779534942 chr6:134979360    G/A rs748588809 chr6:134979372    C/A rs748588809 chr6:134979372    C/T rs763349803 chr6:134979371    TC/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GFM1	chr3:158407476(+) A-I      intronic chr3:158407442(+) A-I      intronic chr3:158407484(+) A-I      intronic chr3:158394592(+) A-I      intronic chr3:158405386(+) A-I      intronic chr3:158391987(+) A-I      intronic chr3:158405396(+) A-I      intronic chr3:158405356(+) A-I      intronic chr3:158392849(+) A-I      intronic chr3:158393898(+) A-I      intronic chr3:158394593(+) A-I      intronic chr3:158392011(+) A-I      intronic chr3:158405326(+) A-I      intronic chr3:158394750(+) A-I      intronic chr3:158374151(+) A-I      3'UTR chr3:158394622(+) A-I      intronic chr3:158393915(+) A-I      intronic chr3:158393917(+) A-I      intronic chr3:158405383(+) A-I      intronic chr3:158392046(+) A-I      intronic chr3:158405382(+) A-I      intronic chr3:158393924(+) A-I      intronic chr3:158394582(+) A-I      intronic chr3:158391925(+) A-I      intronic chr3:158391934(+) A-I      intronic chr3:158393837(+) A-I      intronic chr3:158405374(+) A-I      intronic chr3:158366488(+) A-I      intronic chr3:158404878(+) A-I      intronic chr3:158405361(+) A-I      intronic chr3:158374004(+) A-I      3'UTR chr3:158407423(+) A-I      intronic chr3:158404796(+) A-I      intronic chr3:158393937(+) A-I      intronic chr3:158392009(+) A-I      intronic chr3:158405357(+) A-I      intronic chr3:158407462(+) A-I      intronic chr3:158407388(+) A-I      intronic chr3:158394001(+) A-I      intronic chr3:158407477(+) A-I      intronic chr3:158404856(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GFM1	chr3:158374004(+) A-I intron -    15258596 chr3:158374131(+) A-I intron -    15258596 chr3:158374222(+) A-I intron -    15258596 chr3:158407423(+) A-I intron -    21960545 chr3:158368568(+) T-C intron -    22484847 chr3:158392009(+) A-G intron -    22484847 chr3:158392059(+) T-C intron -    22484847 chr3:158393837(+) A-G intron -    22484847 chr3:158393937(+) A-G intron -    22484847 chr3:158405357(+) A-G intron -    22484847 chr3:158405361(+) A-G intron -    22484847 chr3:158405374(+) A-G intron -    22484847 chr3:158407423(+) A-G intron -    22484847 chr3:158407446(+) A-G intron -    22484847 chr3:158407488(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GFM1	chr3:158363997-158363998(+) m6A CDS       24981863 chr3:158364006-158364007(+) m6A CDS       24981863//27773535 chr3:158403058-158403059(+) m6A exon//intron       - chr3:158408027-158408028(+) m6A 3'UTR//CDS//exon//intron       24209618//27773535 chr3:158408089-158408090(+) m6A 3'UTR//CDS//exon//intron       24209618//27773535 chr3:158408193-158408194(+) m6A exon//intron       24209618 chr3:158408962-158408963(+) m6A 3'UTR//CDS       24209618//24981863//27773535//22608085 chr3:158409251-158409252(+) m6A 3'UTR//CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr3:158409347-158409348(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3662	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	GFM1	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3662
Interactor2: GFM1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.