Basic Information:

  VIRBase ID:  

HHID00073680

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3662:  MIMAT0018083          CCDC6:  NM_005436     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3662	CCDC6
miRBase Accession/Entrez ID	MIMAT0018083	8030
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	D10S170//H4//PTC//TPC//TST1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3662	rs1269591251 chr6:134979367    C/T rs1392974872 chr6:134979361    T/C rs779534942 chr6:134979360    G/A rs748588809 chr6:134979372    C/A rs748588809 chr6:134979372    C/T rs763349803 chr6:134979371    TC/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CCDC6	chr10:61555080(-) A-I      intronic chr10:61591901(-) A-I      intronic chr10:61555079(-) A-I      intronic chr10:61555069(-) A-I      intronic chr10:61555085(-) A-I      intronic chr10:61555068(-) A-I      intronic chr10:61580470(-) A-I      intronic chr10:61577141(-) A-I      intronic chr10:61653153(-) A-I      intronic chr10:61657259(-) A-I      intronic chr10:61577017(-) A-I      intronic chr10:61593098(-) A-I      intronic chr10:61601932(-) A-I      intronic chr10:61653146(-) A-I      intronic chr10:61580325(-) A-I      intronic chr10:61577067(-) A-I      intronic chr10:61577023(-) A-I      intronic chr10:61653165(-) A-I      intronic chr10:61577077(-) A-I      intronic chr10:61653246(-) A-I      intronic chr10:61653356(-) A-I      intronic chr10:61653140(-) A-I      intronic chr10:61613040(-) A-I      intronic chr10:61653092(-) A-I      intronic chr10:61580454(-) A-I      intronic chr10:61653082(-) A-I      intronic chr10:61657302(-) A-I      intronic chr10:61593085(-) A-I      intronic chr10:61593095(-) A-I      intronic chr10:61653276(-) A-I      intronic chr10:61657250(-) A-I      intronic chr10:61653122(-) A-I      intronic chr10:61657150(-) A-I      intronic chr10:61577111(-) A-I      intronic chr10:61608252(-) A-I      intronic chr10:61660740(-) A-I      intronic chr10:61608674(-) A-I      intronic chr10:61577108(-) A-I      intronic chr10:61608324(-) A-I      intronic chr10:61653241(-) A-I      intronic chr10:61657309(-) A-I      intronic chr10:61577133(-) A-I      intronic chr10:61582406(-) A-I      intronic chr10:61653239(-) A-I      intronic chr10:61608668(-) A-I      intronic chr10:61602077(-) A-I      intronic chr10:61580394(-) A-I      intronic chr10:61662290(-) A-I      intronic chr10:61577210(-) A-I      intronic chr10:61608257(-) A-I      intronic chr10:61653127(-) A-I      intronic chr10:61608691(-) A-I      intronic chr10:61608340(-) A-I      intronic chr10:61577161(-) A-I      intronic chr10:61608711(-) A-I      intronic chr10:61608755(-) A-I      intronic chr10:61569477(-) A-I      intronic chr10:61556315(-) A-I      intronic chr10:61556844(-) A-I      intronic chr10:61556333(-) A-I      intronic chr10:61556259(-) A-I      intronic chr10:61653139(-) A-I      intronic chr10:61569638(-) A-I      intronic chr10:61569443(-) A-I      intronic chr10:61569603(-) A-I      intronic chr10:61569604(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CCDC6	chr10:61556844(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CCDC6	chr10:61548549-61548550(-) m6A 3'UTR       27773535 chr10:61548616-61548617(-) m6A 3'UTR       27773535 chr10:61548800-61548801(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr10:61548824-61548825(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr10:61548836-61548837(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr10:61548917-61548918(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:61548934-61548935(-) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr10:61549920-61549921(-) m6A 3'UTR       27773535 chr10:61549991-61549992(-) m6A 3'UTR       27773535 chr10:61549997-61549998(-) m6A 3'UTR       27773535 chr10:61552422-61552423(-) m6A 3'UTR//exon       24284625//24209618//27773535//22575960 chr10:61552642-61552643(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr10:61552793-61552794(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr10:61554247-61554248(-) m6A CDS//exon       24284625//24209618//24981863//27773535 chr10:61564244-61564245(-) m6A CDS//exon       27773535 chr10:61564337-61564338(-) m6A exon//intron       27773535 chr10:61566781-61566782(-) m6A CDS//exon       24981863//27773535//27371828 chr10:61592285-61592286(-) m6A CDS       24981863//27773535 chr10:61592324-61592325(-) m6A CDS       24981863//27773535//27371828 chr10:61592345-61592346(-) m6A CDS       24981863//27773535//27371828 chr10:61592356-61592357(-) Cm CDS       - chr10:61592372-61592373(-) m6A CDS       24981863//27773535//27371828 chr10:61592384-61592385(-) m6A CDS       24981863//27773535 chr10:61592390-61592391(-) m6A CDS       24981863//27773535 chr10:61612378-61612379(-) m6A CDS       24981863//27773535 chr10:61665910-61665911(-) m6A CDS       24209618//24981863 chr10:61665939-61665940(-) m6A CDS       24209618//24981863 chr10:61665947-61665948(-) m6A CDS       24209618//24981863 chr10:61665973-61665974(-) m6A CDS       24209618//24981863//27773536 chr10:61666174-61666175(-) m6A CDS       24981863//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3662	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	CCDC6	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3662
Interactor2: CCDC6

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.