Basic Information:

  VIRBase ID:  

HHID00073636

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3662:  MIMAT0018083          NFKB1:  NM_001319226     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3662	NFKB1
miRBase Accession/Entrez ID	MIMAT0018083	4790
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CVID12//EBP-1//KBF1//NF-kappa-B1//NF-kappaB//NF-kappabeta//NF-kB//NF-kB1//NFkappaB//NFKB-p105//NFKB-p50

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3662	rs1269591251 chr6:134979367    C/T rs1392974872 chr6:134979361    T/C rs779534942 chr6:134979360    G/A rs748588809 chr6:134979372    C/A rs748588809 chr6:134979372    C/T rs763349803 chr6:134979371    TC/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NFKB1	chr4:103523438(+) A-I      intronic chr4:103523449(+) A-I      intronic chr4:103523459(+) A-I      intronic chr4:103493795(+) A-I      intronic chr4:103492977(+) A-I      intronic chr4:103492953(+) A-I      intronic chr4:103491504(+) A-I      intronic chr4:103491499(+) A-I      intronic chr4:103491467(+) A-I      intronic chr4:103465253(+) A-I      intronic chr4:103524504(+) A-I      intronic chr4:103524508(+) A-I      intronic chr4:103523433(+) A-I      intronic chr4:103524404(+) A-I      intronic chr4:103524369(+) A-I      intronic chr4:103524359(+) A-I      intronic chr4:103524347(+) A-I      intronic chr4:103524330(+) A-I      intronic chr4:103523603(+) A-I      intronic chr4:103481082(+) A-I      intronic chr4:103479949(+) A-I      intronic chr4:103479851(+) A-I      intronic chr4:103433632(+) A-I      intronic chr4:103433605(+) A-I      intronic chr4:103432839(+) A-I      intronic chr4:103432582(+) A-I      intronic chr4:103480975(+) A-I      intronic chr4:103524467(+) A-I      intronic chr4:103433606(+) A-I      intronic chr4:103479909(+) A-I      intronic chr4:103523426(+) A-I      intronic chr4:103432753(+) A-I      intronic chr4:103432590(+) A-I      intronic chr4:103432816(+) A-I      intronic chr4:103523576(+) A-I      intronic chr4:103432576(+) A-I      intronic chr4:103479947(+) A-I      intronic chr4:103432560(+) A-I      intronic chr4:103524281(+) A-I      intronic chr4:103432739(+) A-I      intronic chr4:103479811(+) A-I      intronic chr4:103433631(+) A-I      intronic chr4:103433610(+) A-I      intronic chr4:103479934(+) A-I      intronic chr4:103479920(+) A-I      intronic chr4:103480821(+) A-I      intronic chr4:103433724(+) A-I      intronic chr4:103480827(+) A-I      intronic chr4:103481040(+) A-I      intronic chr4:103435067(+) A-I      intronic chr4:103480989(+) A-I      intronic chr4:103523432(+) A-I      intronic chr4:103481050(+) A-I      intronic chr4:103479831(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	NFKB1	chr4:103480975(+) A-I intron -    22327324 chr4:103491632(+) A-G intron -    22484847 chr4:103491738(+) A-G intron -    22484847 chr4:103493713(+) A-G intron -    22484847 chr4:103493734(+) A-G intron -    22484847 chr4:103432560(+) A-G intron -    22484847 chr4:103432576(+) A-G intron -    22484847 chr4:103432590(+) A-G intron -    22484847 chr4:103432646(+) A-G intron -    22484847 chr4:103432650(+) A-G intron -    22484847 chr4:103432753(+) A-G intron -    22484847 chr4:103432816(+) A-G intron -    22484847 chr4:103433557(+) A-G intron -    22484847 chr4:103433606(+) A-G intron -    22484847 chr4:103433610(+) A-G intron -    22484847 chr4:103433618(+) A-G intron -    22484847 chr4:103433623(+) A-G intron -    22484847 chr4:103433631(+) A-G intron -    22484847 chr4:103435067(+) A-G intron -    22484847 chr4:103479811(+) A-G intron -    22484847 chr4:103479831(+) A-G intron -    22484847 chr4:103479877(+) A-G intron -    22484847 chr4:103479920(+) A-G intron -    22484847 chr4:103479934(+) A-G intron -    22484847 chr4:103479937(+) A-G intron -    22484847 chr4:103480975(+) A-G intron -    22484847 chr4:103480989(+) A-G intron -    22484847 chr4:103523426(+) A-G intron -    22484847 chr4:103523430(+) A-G intron -    22484847 chr4:103523576(+) A-G intron -    22484847 chr4:103523638(+) A-G intron -    22484847 chr4:103524281(+) A-G intron -    22484847 chr4:103524467(+) A-G intron -    22484847 chr4:103530591(+) A-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NFKB1	chr4:103422502-103422503(+) m6A 5'UTR       24981863 chr4:103517354-103517355(+) m6A CDS//exon       26404942 chr4:103517363-103517364(+) m6A CDS//exon       26404942 chr4:103517386-103517387(+) m6A CDS//exon       26404942 chr4:103517461-103517462(+) m6A CDS//exon       26404942 chr4:103537602-103537603(+) m6A CDS       24284625 chr4:103537634-103537635(+) m6A CDS       24284625//24981863//26404942 chr4:103537648-103537649(+) m6A CDS       24284625//24981863//26404942 chr4:103537729-103537730(+) m6A CDS       24284625//24981863//26404942//22608085 chr4:103537779-103537780(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr4:103537815-103537816(+) m6A 3'UTR       24284625//24981863//26404942//22608085 chr4:103537886-103537887(+) m6A 3'UTR       24284625//26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3662	Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     - Mitochondrion Cell line (HEK-293|HeLa)     22984580
	NFKB1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HeLa-S3 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3662
Interactor2: NFKB1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.