Basic Information:

  VIRBase ID:  

HHID00073561

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3659:  MIMAT0018080          STARD3NL:  NM_001363347     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3659	STARD3NL
miRBase Accession/Entrez ID	MIMAT0018080	83930
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	MENTHO

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3659	rs1252425125 chr1:38089301    AC/A rs558225828 chr1:38089302    C/T rs897732813 chr1:38089307    G/C rs1014788758 chr1:38089292    G/A rs923643532 chr1:38089294    G/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	STARD3NL	chr7:38259446(+) A-I      intronic chr7:38259451(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	STARD3NL	chr7:38261010(+) A-G intron -    22484847 chr7:38241436(+) G-C intron -    22484847 chr7:38241437(+) C-T intron -    22484847 chr7:38241438(+) A-T intron -    22484847 chr7:38259413(+) A-G intron -    22484847 chr7:38259419(+) A-G intron -    22484847 chr7:38259447(+) A-G intron -    22484847 chr7:38260934(+) A-G intron -    22484847 chr7:38260936(+) A-G intron -    22484847 chr7:38260937(+) A-G intron -    22484847 chr7:38260943(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	STARD3NL	chr7:38217911-38217912(+) m6A 5'UTR       24981863 chr7:38218009-38218010(+) m6A 5'UTR//exon       24981863 chr7:38247109-38247110(+) m6A CDS//exon       24284625 chr7:38247124-38247125(+) m6A CDS//exon       24284625 chr7:38247264-38247265(+) m6A CDS//exon       24284625//24981863//27773535 chr7:38253976-38253977(+) m6A CDS//exon       27773535 chr7:38269714-38269715(+) Y 3'UTR//exon       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3659	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	STARD3NL	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3659
Interactor2: STARD3NL

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.