Detail Information

Basic Information:


  VIRBase ID:  

HHID00073387

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-3653-3p ACTG1
miRBase
Accession/Entrez ID		 MIMAT0018073 71
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ACT//ACTG//DFNA20//DFNA26//HEL-176

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR ACTG1
chr17:79478136(-) A-I      intronic
chr17:79477169(-) A-I      3'UTR
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ACTG1
chr17:79478136(-) A-I intron -    19478186
chr17:79479390(-) G-T intron -    21725310

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ACTG1
chr17:79477186-79477187(-) Gm 3'UTR//exon       -
chr17:79477196-79477197(-) Tm 3'UTR//exon       -
chr17:79477247-79477248(-) m6A 3'UTR//exon       22575960
chr17:79477300-79477301(-) m6A 3'UTR//exon       22575960
chr17:79477407-79477408(-) m6A 3'UTR//exon//intron       22575960
chr17:79477550-79477551(-) m6A 3'UTR//exon       24284625//24981863//26404942//22575960
chr17:79477618-79477619(-) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//27371828//22575960
chr17:79477704-79477705(-) Cm 3'UTR//exon       -
chr17:79477710-79477711(-) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//27371828//22575960
chr17:79478061-79478062(-) m6A 3'UTR//CDS//exon       27773535//22575960
chr17:79478073-79478074(-) m6A 3'UTR//CDS//exon       27773535//22575960
chr17:79478107-79478108(-) m6A 3'UTR//CDS//exon       22575960
chr17:79478350-79478351(-) m6A 3'UTR//CDS//exon       22575960
chr17:79478464-79478465(-) m6A CDS//exon       24981863//26404942//27773535//22575960
chr17:79478479-79478480(-) m6A CDS//exon       24981863//26404942//27773535//22575960
chr17:79478554-79478555(-) m6A CDS//exon       24981863//26404942//27773535//22575960
chr17:79478639-79478640(-) m6A CDS//exon//intron       24981863//27773535//22575960
chr17:79478959-79478960(-) m6A CDS//exon       24284625//27773535//22575960
chr17:79479139-79479140(-) m6A CDS//exon       24284625//27773535//22575960
chr17:79479263-79479264(-) m6A CDS//exon       24284625//27773535//22575960
chr17:79479372-79479373(-) m1A CDS//exon       26863196//26863410
chr17:79479431-79479432(-) m6A 5'UTR//intron       24284625//22575960
chr17:79479569-79479570(-) m6A 5'UTR//intron       27371828
chr17:79479651-79479652(-) m6A 5'UTR//intron       27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-3653-3p
Exosome Plasma     23663360
Mitochondrion Cell line (HEK-293)     22984580
ACTG1
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol HCC cell line (HepG2)|HeLa-S3 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-3653-3p
Interactor2: ACTG1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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