Basic Information:

  VIRBase ID:  

HHID00073056

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3609:  MIMAT0017986          SPRED1:  NM_152594     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3609	SPRED1
miRBase Accession/Entrez ID	MIMAT0017986	161742
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	hSpred1//LGSS//NFLS//PPP1R147//spred-1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3609	rs1201010739 chr7:98881721    C/A rs1379314154 chr7:98881711    G/T rs1433840969 chr7:98881723    G/A rs1360895354 chr7:98881703    A/C rs955400524 chr7:98881707    A/G rs955400524 chr7:98881707    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SPRED1	chr15:38597488(+) A-I      intronic chr15:38597474(+) A-I      intronic chr15:38597483(+) A-I      intronic chr15:38597485(+) A-I      intronic chr15:38649331(+) A-I      3'UTR chr15:38597482(+) A-I      intronic chr15:38617239(+) A-I      intronic chr15:38573825(+) A-I      intronic chr15:38570604(+) A-I      intronic chr15:38562178(+) A-I      intronic chr15:38570495(+) A-I      intronic chr15:38571278(+) A-I      intronic chr15:38562373(+) A-I      intronic chr15:38562368(+) A-I      intronic chr15:38574690(+) A-I      intronic chr15:38570580(+) A-I      intronic chr15:38571098(+) A-I      intronic chr15:38571168(+) A-I      intronic chr15:38574426(+) A-I      intronic chr15:38597320(+) A-I      intronic chr15:38597331(+) A-I      intronic chr15:38617229(+) A-I      intronic chr15:38574398(+) A-I      intronic chr15:38617249(+) A-I      intronic chr15:38567722(+) A-I      intronic chr15:38567720(+) A-I      intronic chr15:38624506(+) A-I      intronic chr15:38564494(+) A-I      intronic chr15:38570561(+) A-I      intronic chr15:38595181(+) A-I      intronic chr15:38578263(+) A-I      intronic chr15:38567792(+) A-I      intronic chr15:38570534(+) A-I      intronic chr15:38570427(+) A-I      intronic chr15:38574466(+) A-I      intronic chr15:38573868(+) A-I      intronic chr15:38597386(+) A-I      intronic chr15:38573880(+) A-I      intronic chr15:38567896(+) A-I      intronic chr15:38578187(+) A-I      intronic chr15:38567725(+) A-I      intronic chr15:38562209(+) A-I      intronic chr15:38601581(+) A-I      intronic chr15:38570581(+) A-I      intronic chr15:38638283(+) A-I      intronic chr15:38601616(+) A-I      intronic chr15:38567958(+) A-I      intronic chr15:38574620(+) A-I      intronic chr15:38570484(+) A-I      intronic chr15:38573727(+) A-I      intronic chr15:38573663(+) A-I      intronic chr15:38548956(+) A-I      intronic chr15:38624707(+) A-I      intronic chr15:38567718(+) A-I      intronic chr15:38570500(+) A-I      intronic chr15:38567799(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SPRED1	chr15:38567718(+) A-I intron -    15342557 chr15:38567720(+) A-I intron -    15342557 chr15:38567722(+) A-I intron -    15342557 chr15:38567725(+) A-I intron -    15342557 chr15:38567792(+) A-I intron -    15342557 chr15:38567799(+) A-I intron -    15342557 chr15:38567896(+) A-I intron -    15342557 chr15:38567958(+) A-I intron -    15342557 chr15:38570022(+) A-I intron -    15342557 chr15:38570091(+) A-I intron -    15342557 chr15:38570427(+) A-I intron -    15342557 chr15:38570484(+) A-I intron -    15342557 chr15:38570500(+) A-I intron -    15342557 chr15:38570561(+) A-I intron -    15342557 chr15:38570581(+) A-I intron -    15342557 chr15:38570604(+) A-I intron -    15342557

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SPRED1	chr15:38544636-38544637(+) m6A 5'UTR       - chr15:38544810-38544811(+) m6A 5'UTR       25456834 chr15:38544885-38544886(+) m6A 5'UTR       25456834 chr15:38618211-38618212(+) m6A exon//intron       24981863 chr15:38618218-38618219(+) m6A exon//intron       24981863 chr15:38618224-38618225(+) m6A exon//intron       24981863 chr15:38618280-38618281(+) m6A exon//intron       24981863 chr15:38618345-38618346(+) m6A exon//intron       24981863 chr15:38632035-38632036(+) m6A CDS       - chr15:38643234-38643235(+) m6A CDS       24981863//22608085 chr15:38643275-38643276(+) m6A CDS       24209618//24981863//22575960//22608085 chr15:38643308-38643309(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr15:38643315-38643316(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr15:38643381-38643382(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:38643386-38643387(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:38643401-38643402(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:38643427-38643428(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr15:38643449-38643450(+) m6A CDS       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr15:38643599-38643600(+) m6A CDS       24284625//24209618//24981863//22575960//22608085 chr15:38643674-38643675(+) m6A CDS       24284625//24981863//22575960//22608085 chr15:38644193-38644194(+) m6A 3'UTR       24981863//22608085 chr15:38644219-38644220(+) m6A 3'UTR       24981863//22608085 chr15:38644225-38644226(+) m6A 3'UTR       24981863//22608085 chr15:38644250-38644251(+) m6A 3'UTR       24981863//22608085 chr15:38644303-38644304(+) m6A 3'UTR       24981863 chr15:38646545-38646546(+) m6A 3'UTR       24981863 chr15:38646603-38646604(+) m6A 3'UTR       24981863//22608085 chr15:38646616-38646617(+) m6A 3'UTR       24981863//22608085 chr15:38646666-38646667(+) m6A 3'UTR       24981863//22608085 chr15:38646740-38646741(+) m6A 3'UTR       24981863//22608085 chr15:38646826-38646827(+) m6A 3'UTR       24981863 chr15:38646839-38646840(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3609	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)     -
	SPRED1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3609
Interactor2: SPRED1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.