Basic Information:

  VIRBase ID:  

HHID00073043

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3609:  MIMAT0017986          CBX3:  NM_016587     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3609	CBX3
miRBase Accession/Entrez ID	MIMAT0017986	11335
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HECH//HP1-GAMMA//HP1Hs-gamma

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3609	rs1201010739 chr7:98881721    C/A rs1379314154 chr7:98881711    G/T rs1433840969 chr7:98881723    G/A rs1360895354 chr7:98881703    A/C rs955400524 chr7:98881707    A/G rs955400524 chr7:98881707    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CBX3	chr7:26247399(+) A-I      intronic chr7:26247358(+) A-I      intronic chr7:26245456(+) A-I      intronic chr7:26244474(+) A-I      intronic chr7:26244453(+) A-I      intronic chr7:26247611(+) A-I      intronic chr7:26247635(+) A-I      intronic chr7:26247621(+) A-I      intronic chr7:26247629(+) A-I      intronic chr7:26247575(+) A-I      intronic chr7:26247576(+) A-I      intronic chr7:26247644(+) A-I      intronic chr7:26244527(+) A-I      intronic chr7:26247625(+) A-I      intronic chr7:26247763(+) A-I      intronic chr7:26247208(+) A-I      intronic chr7:26244683(+) A-I      intronic chr7:26247338(+) A-I      intronic chr7:26247829(+) A-I      intronic chr7:26245530(+) A-I      intronic chr7:26247645(+) A-I      intronic chr7:26245548(+) A-I      intronic chr7:26247581(+) A-I      intronic chr7:26244510(+) A-I      intronic chr7:26245680(+) A-I      intronic chr7:26244428(+) A-I      intronic chr7:26245651(+) A-I      intronic chr7:26247630(+) A-I      intronic chr7:26244458(+) A-I      intronic chr7:26247268(+) A-I      intronic chr7:26245611(+) A-I      intronic chr7:26247318(+) A-I      intronic chr7:26245451(+) A-I      intronic chr7:26245520(+) A-I      intronic chr7:26247278(+) A-I      intronic chr7:26247736(+) A-I      intronic chr7:26247700(+) A-I      intronic chr7:26245542(+) A-I      intronic chr7:26245550(+) A-I      intronic chr7:26244689(+) A-I      intronic chr7:26245586(+) A-I      intronic chr7:26244539(+) A-I      intronic chr7:26248405(+) A-I      intronic chr7:26245598(+) A-I      intronic chr7:26247265(+) A-I      intronic chr7:26247825(+) A-I      intronic chr7:26248440(+) A-I      intronic chr7:26244551(+) A-I      intronic chr7:26244466(+) A-I      intronic chr7:26249760(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CBX3	chr7:26244458(+) A-G intron -    22484847 chr7:26244460(+) A-G intron -    22484847 chr7:26244466(+) A-G intron -    22484847 chr7:26244583(+) A-G intron -    22484847 chr7:26245450(+) A-G intron -    22484847 chr7:26247318(+) A-G intron -    22484847 chr7:26247338(+) A-G intron -    22484847 chr7:26247645(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CBX3	chr7:26240841-26240842(+) m6A 5'UTR       27773535 chr7:26240912-26240913(+) m6A 5'UTR       24981863//27773535 chr7:26241108-26241109(+) m6A 5'UTR       25456834//24981863 chr7:26241156-26241157(+) m6A 5'UTR       25456834//24981863 chr7:26241413-26241414(+) m6A 5'UTR//intron       24284625//24981863//27773535 chr7:26241554-26241555(+) m6A 5'UTR//intron       24284625//27773535 chr7:26242560-26242561(+) m6A exon//intron       24981863//27773535 chr7:26242633-26242634(+) m6A CDS//exon       24981863//27773535 chr7:26245702-26245703(+) m6A exon//intron       24981863//27773535 chr7:26245722-26245723(+) m6A exon//intron       24981863//27773535 chr7:26246004-26246005(+) m6A CDS//exon       24981863//27773535//22575960 chr7:26247831-26247832(+) m6A exon//intron       27773535 chr7:26248001-26248002(+) m6A exon//intron       24981863 chr7:26248006-26248007(+) m6A exon//intron       24981863 chr7:26248030-26248031(+) m6A CDS//exon//intron       24981863 chr7:26249672-26249673(+) m6A 3'UTR//intron       27773535 chr7:26250170-26250171(+) m6A 3'UTR//intron       24981863 chr7:26251289-26251290(+) m6A CDS//exon       24981863 chr7:26251342-26251343(+) m6A 3'UTR//CDS//exon       27773535 chr7:26251721-26251722(+) m6A 3'UTR//CDS//exon       27773535 chr7:26251788-26251789(+) m6A 3'UTR//CDS//exon       27773535 chr7:26252012-26252013(+) m6A 3'UTR//exon       27773535 chr7:26252537-26252538(+) m6A 3'UTR       27773535 chr7:26252542-26252543(+) m6A 3'UTR       27773535 chr7:26252571-26252572(+) m6A 3'UTR       27773535 chr7:26252576-26252577(+) m6A 3'UTR       27773535 chr7:26252590-26252591(+) m6A 3'UTR       27773535 chr7:26252687-26252688(+) m6A 3'UTR       27773535 chr7:26252702-26252703(+) m6A 3'UTR       27773535 chr7:26252738-26252739(+) m6A 3'UTR       27773535 chr7:26252760-26252761(+) m6A 3'UTR       27773535 chr7:26252872-26252873(+) m6A 3'UTR       27773535 chr7:26252938-26252939(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3609	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)     -
	CBX3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3609
Interactor2: CBX3

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.