Basic Information:

  VIRBase ID:  

HHID00073022

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3609:  MIMAT0017986          LIMK1:  NM_002314     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3609	LIMK1
miRBase Accession/Entrez ID	MIMAT0017986	3984
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	LIMK//LIMK-1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3609	rs1201010739 chr7:98881721    C/A rs1379314154 chr7:98881711    G/T rs1433840969 chr7:98881723    G/A rs1360895354 chr7:98881703    A/C rs955400524 chr7:98881707    A/G rs955400524 chr7:98881707    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	LIMK1	chr7:73514366(+) A-I      intronic chr7:73514234(+) A-I      intronic chr7:73514188(+) A-I      intronic chr7:73514182(+) A-I      intronic chr7:73514178(+) A-I      intronic chr7:73513939(+) A-I      intronic chr7:73513937(+) A-I      intronic chr7:73513908(+) A-I      intronic chr7:73513903(+) A-I      intronic chr7:73513899(+) A-I      intronic chr7:73510751(+) A-I      intronic chr7:73510724(+) A-I      intronic chr7:73510710(+) A-I      intronic chr7:73509748(+) A-I      intronic chr7:73505782(+) A-I      intronic chr7:73505772(+) A-I      intronic chr7:73505694(+) A-I      intronic chr7:73505446(+) A-I      intronic chr7:73505385(+) A-I      intronic chr7:73505373(+) A-I      intronic chr7:73505370(+) A-I      intronic chr7:73505369(+) A-I      intronic chr7:73505308(+) A-I      intronic chr7:73532043(+) A-I      intronic chr7:73503693(+) A-I      intronic chr7:73502381(+) A-I      intronic chr7:73514981(+) A-I      intronic chr7:73514982(+) A-I      intronic chr7:73515207(+) A-I      intronic chr7:73515341(+) A-I      intronic chr7:73515763(+) A-I      intronic chr7:73515782(+) A-I      intronic chr7:73515793(+) A-I      intronic chr7:73516368(+) A-I      intronic chr7:73516389(+) A-I      intronic chr7:73516888(+) A-I      intronic chr7:73516893(+) A-I      intronic chr7:73516899(+) A-I      intronic chr7:73516907(+) A-I      intronic chr7:73516913(+) A-I      intronic chr7:73516914(+) A-I      intronic chr7:73516926(+) A-I      intronic chr7:73516940(+) A-I      intronic chr7:73516953(+) A-I      intronic chr7:73517219(+) A-I      intronic chr7:73517224(+) A-I      intronic chr7:73517433(+) A-I      intronic chr7:73517450(+) A-I      intronic chr7:73518156(+) A-I      intronic chr7:73518224(+) A-I      intronic chr7:73518225(+) A-I      intronic chr7:73518242(+) A-I      intronic chr7:73518375(+) A-I      intronic chr7:73518482(+) A-I      intronic chr7:73518490(+) A-I      intronic chr7:73518496(+) A-I      intronic chr7:73518501(+) A-I      intronic chr7:73518754(+) A-I      intronic chr7:73518766(+) A-I      intronic chr7:73518770(+) A-I      intronic chr7:73518774(+) A-I      intronic chr7:73518791(+) A-I      intronic chr7:73518795(+) A-I      intronic chr7:73518943(+) A-I      intronic chr7:73519347(+) A-I      intronic chr7:73519410(+) A-I      intronic chr7:73519696(+) A-I      intronic chr7:73519722(+) A-I      intronic chr7:73519736(+) A-I      intronic chr7:73531133(+) A-I      intronic chr7:73531171(+) A-I      intronic chr7:73532089(+) A-I      intronic chr7:73532586(+) A-I      intronic chr7:73533005(+) A-I      intronic chr7:73534159(+) A-I      intronic chr7:73534163(+) A-I      intronic chr7:73534170(+) A-I      intronic chr7:73534179(+) A-I      intronic chr7:73514852(+) A-I      intronic chr7:73502307(+) A-I      intronic chr7:73502142(+) A-I      intronic chr7:73502103(+) A-I      intronic chr7:73502182(+) A-I      intronic chr7:73502019(+) A-I      intronic chr7:73500930(+) A-I      intronic chr7:73500875(+) A-I      intronic chr7:73534217(+) A-I      intronic chr7:73534220(+) A-I      intronic chr7:73502155(+) A-I      intronic chr7:73505307(+) A-I      intronic chr7:73514230(+) A-I      intronic chr7:73514865(+) A-I      intronic chr7:73514967(+) A-I      intronic chr7:73514870(+) A-I      intronic chr7:73514856(+) A-I      intronic chr7:73514853(+) A-I      intronic chr7:73514833(+) A-I      intronic chr7:73514774(+) A-I      intronic chr7:73514499(+) A-I      intronic chr7:73514370(+) A-I      intronic chr7:73514843(+) A-I      intronic chr7:73532959(+) A-I      intronic chr7:73515783(+) A-I      intronic chr7:73513900(+) A-I      intronic chr7:73510621(+) A-I      intronic chr7:73502911(+) A-I      intronic chr7:73515271(+) A-I      intronic chr7:73513805(+) A-I      intronic chr7:73519349(+) A-I      intronic chr7:73500802(+) A-I      intronic chr7:73513799(+) A-I      intronic chr7:73519389(+) A-I      intronic chr7:73513829(+) A-I      intronic chr7:73519417(+) A-I      intronic chr7:73515787(+) A-I      intronic chr7:73502357(+) A-I      intronic chr7:73518876(+) A-I      intronic chr7:73532960(+) A-I      intronic chr7:73500559(+) A-I      intronic chr7:73502020(+) A-I      intronic chr7:73518358(+) A-I      intronic chr7:73515274(+) A-I      intronic chr7:73505383(+) A-I      intronic chr7:73519268(+) A-I      intronic chr7:73502000(+) A-I      intronic chr7:73514181(+) A-I      intronic chr7:73513875(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	LIMK1	chr7:73513787(+) A-I intron -    15258596 chr7:73513799(+) A-I intron -    15258596 chr7:73513805(+) A-I intron -    15258596 chr7:73513829(+) A-I intron -    15258596 chr7:73513875(+) A-I intron -    15258596 chr7:73513900(+) A-I intron -    15258596 chr7:73514181(+) A-I intron -    22327324

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	LIMK1	chr7:73497481-73497482(+) m6A CDS       24209618 chr7:73521470-73521471(+) m6A 3'UTR//CDS//exon       - chr7:73522215-73522216(+) m6A 3'UTR//CDS//exon       - chr7:73522263-73522264(+) m6A 3'UTR//CDS//exon       - chr7:73523257-73523258(+) m6A 3'UTR//CDS//exon       - chr7:73523298-73523299(+) m6A 3'UTR//CDS//exon       - chr7:73525757-73525758(+) m6A exon//intron       24981863 chr7:73526020-73526021(+) m6A 3'UTR//CDS       24981863 chr7:73526281-73526282(+) m6A 3'UTR//CDS       24981863 chr7:73526296-73526297(+) m6A 3'UTR//CDS       24981863 chr7:73530132-73530133(+) m6A 3'UTR//CDS//exon       - chr7:73530188-73530189(+) m6A 3'UTR//CDS//exon       - chr7:73530225-73530226(+) m6A 3'UTR//CDS//exon       - chr7:73535243-73535244(+) m6A 3'UTR//CDS//exon       - chr7:73535270-73535271(+) m6A 3'UTR//CDS//exon       - chr7:73535300-73535301(+) m6A 3'UTR//CDS//exon       24284625 chr7:73535318-73535319(+) m6A 3'UTR//CDS//exon       24284625 chr7:73535366-73535367(+) m6A 3'UTR//CDS       24284625//24981863 chr7:73535489-73535490(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085 chr7:73535502-73535503(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085 chr7:73535560-73535561(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085 chr7:73535577-73535578(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085 chr7:73535600-73535601(+) m6A 3'UTR//CDS       24284625//25456834//24981863//22608085 chr7:73535717-73535718(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr7:73535726-73535727(+) m6A 3'UTR       24284625//25456834//24981863//22608085 chr7:73535779-73535780(+) m6A 3'UTR       24284625//25456834//24981863 chr7:73536417-73536418(+) m6A 3'UTR       24981863 chr7:73536687-73536688(+) m6A 3'UTR       24981863 chr7:73536715-73536716(+) m6A 3'UTR       24284625//24981863//27773535 chr7:73536724-73536725(+) m6A 3'UTR       24284625//24981863//27773535 chr7:73536746-73536747(+) m6A 3'UTR       24284625//24981863//27773535 chr7:73536767-73536768(+) m6A 3'UTR       24284625//24981863//27773535 chr7:73536789-73536790(+) m6A 3'UTR       24284625//24981863//27773535 chr7:73536806-73536807(+) m6A 3'UTR       24284625//24981863//27773535 chr7:73536811-73536812(+) m6A 3'UTR       24284625//24981863//27773535 chr7:73536824-73536825(+) m6A 3'UTR       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3609	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)     -
	LIMK1	Chromatin K562 cells     - Cytosol HeLa-S3 cells|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3609
Interactor2: LIMK1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.