Basic Information:

  VIRBase ID:  

HHID00073012

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3609:  MIMAT0017986          B2M:  NM_004048     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3609	B2M
miRBase Accession/Entrez ID	MIMAT0017986	567
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	IMD43

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3609	rs1201010739 chr7:98881721    C/A rs1379314154 chr7:98881711    G/T rs1433840969 chr7:98881723    G/A rs1360895354 chr7:98881703    A/C rs955400524 chr7:98881707    A/G rs955400524 chr7:98881707    A/T

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	B2M	chr15:45004954(+) A-I      intronic chr15:45004928(+) A-I      intronic chr15:45005196(+) A-I      intronic chr15:45006855(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	B2M	chr15:45005197(+) G-A intron -    22484847 chr15:45006943(+) T-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	B2M	chr15:45007770-45007771(+) m6A 3'UTR//CDS//exon//intron       24284625//26404942//27773535 chr15:45007788-45007789(+) m6A 3'UTR//CDS//exon//intron       24284625//26404942//27773535 chr15:45007860-45007861(+) m6A 3'UTR//CDS//exon//intron       24284625//26404942//27773535 chr15:45009121-45009122(+) m6A 3'UTR//exon//intron       26404942 chr15:45009127-45009128(+) m6A 3'UTR//exon//intron       26404942 chr15:45009202-45009203(+) m6A 3'UTR//exon//intron       26404942//22575960 chr15:45009920-45009921(+) Y 3'UTR//exon//intron       26075521 chr15:45009928-45009929(+) m6A 3'UTR//exon//intron       26404942//27773535//22575960 chr15:45010027-45010028(+) Gm 3'UTR//exon//intron       - chr15:45010082-45010083(+) m6A 3'UTR//exon//intron       26404942//27773535//22575960 chr15:45010228-45010229(+) m6A 3'UTR//exon//intron       27773535//22575960 chr15:45010622-45010623(+) m6A 3'UTR//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3609	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)     -
	B2M	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Plasma     - Nucleus Nasopharyngeal carcinoma cells     20498841 Polysome HeLa cells     25063809 Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3609
Interactor2: B2M

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.