Detail Information

Basic Information:


  VIRBase ID:  

HHID00073009

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-3607-3p CEP57L1
miRBase
Accession/Entrez ID		 MIMAT0017985 285753
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - bA487F23.2//C6orf182//cep57R

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CEP57L1
chr6:109421731(+) A-I      intronic
chr6:109421726(+) A-I      intronic
chr6:109421725(+) A-I      intronic
chr6:109474056(+) A-I      intronic
chr6:109421663(+) A-I      intronic
chr6:109474078(+) A-I      intronic
chr6:109474034(+) A-I      intronic
chr6:109421720(+) A-I      intronic
chr6:109474057(+) A-I      intronic
chr6:109421719(+) A-I      intronic
chr6:109421713(+) A-I      intronic
chr6:109419539(+) A-I      intronic
chr6:109419665(+) A-I      intronic
chr6:109419669(+) A-I      intronic
chr6:109419672(+) A-I      intronic
chr6:109419897(+) A-I      intronic
chr6:109419948(+) A-I      intronic
chr6:109419978(+) A-I      intronic
chr6:109421701(+) A-I      intronic
chr6:109421784(+) A-I      intronic
chr6:109422100(+) A-I      intronic
chr6:109422139(+) A-I      intronic
chr6:109422145(+) A-I      intronic
chr6:109422150(+) A-I      intronic
chr6:109422196(+) A-I      intronic
chr6:109422242(+) A-I      intronic
chr6:109422260(+) A-I      intronic
chr6:109422280(+) A-I      intronic
chr6:109425872(+) A-I      intronic
chr6:109425886(+) A-I      intronic
chr6:109425898(+) A-I      intronic
chr6:109427922(+) A-I      intronic
chr6:109427947(+) A-I      intronic
chr6:109428118(+) A-I      intronic
chr6:109429483(+) A-I      intronic
chr6:109429513(+) A-I      intronic
chr6:109429624(+) A-I      intronic
chr6:109429637(+) A-I      intronic
chr6:109429644(+) A-I      intronic
chr6:109429710(+) A-I      intronic
chr6:109437442(+) A-I      intronic
chr6:109437614(+) A-I      intronic
chr6:109439300(+) A-I      intronic
chr6:109439365(+) A-I      intronic
chr6:109439368(+) A-I      intronic
chr6:109443894(+) A-I      intronic
chr6:109445124(+) A-I      intronic
chr6:109449023(+) A-I      intronic
chr6:109474508(+) A-I      intronic
chr6:109474562(+) A-I      intronic
chr6:109439429(+) A-I      intronic
chr6:109419492(+) A-I      intronic
chr6:109419508(+) A-I      intronic
chr6:109448923(+) A-I      intronic
chr6:109421691(+) A-I      intronic
chr6:109425846(+) A-I      intronic
chr6:109429033(+) A-I      intronic
chr6:109445171(+) A-I      intronic
chr6:109428979(+) A-I      intronic
chr6:109428984(+) A-I      intronic
chr6:109429543(+) A-I      intronic
chr6:109421668(+) A-I      intronic
chr6:109421655(+) A-I      intronic
chr6:109420770(+) A-I      intronic
chr6:109425999(+) A-I      intronic
chr6:109425979(+) A-I      intronic
chr6:109461832(+) A-I      intronic
chr6:109427912(+) A-I      intronic
chr6:109421757(+) A-I      intronic
chr6:109423531(+) A-I      intronic
chr6:109437507(+) A-I      intronic
chr6:109479490(+) A-I      3'UTR
chr6:109445127(+) A-I      intronic
chr6:109427941(+) A-I      intronic
chr6:109448924(+) A-I      intronic
chr6:109425835(+) A-I      intronic
chr6:109421623(+) A-I      intronic
chr6:109421606(+) A-I      intronic
chr6:109422167(+) A-I      intronic
chr6:109474726(+) A-I      intronic
chr6:109471853(+) A-I      intronic
chr6:109474043(+) A-I      intronic
chr6:109462474(+) A-I      intronic
chr6:109474194(+) A-I      intronic
chr6:109474670(+) A-I      intronic
chr6:109421692(+) A-I      intronic
chr6:109460555(+) A-I      intronic
chr6:109427930(+) A-I      intronic
chr6:109474193(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED CEP57L1
chr6:109419623(+) A-G intron -    22484847
chr6:109421606(+) A-G intron -    22484847
chr6:109421620(+) A-G intron -    22484847
chr6:109421622(+) A-G intron -    22484847
chr6:109421623(+) A-G intron -    22484847
chr6:109421757(+) A-G intron -    22484847
chr6:109422216(+) A-G intron -    22484847
chr6:109425811(+) A-G intron -    22484847
chr6:109425833(+) A-G intron -    22484847
chr6:109425835(+) A-G intron -    22484847
chr6:109425887(+) A-G intron -    22484847
chr6:109425979(+) A-G intron -    22484847
chr6:109425999(+) A-G intron -    22484847
chr6:109427930(+) A-G intron -    22484847
chr6:109427941(+) A-G intron -    22484847
chr6:109428007(+) A-G intron -    22484847
chr6:109428984(+) A-G intron -    22484847
chr6:109429543(+) A-G intron -    22484847
chr6:109429544(+) A-G intron -    22484847
chr6:109437507(+) A-G intron -    22484847
chr6:109443822(+) A-G intron -    22484847
chr6:109448319(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CEP57L1
chr6:109416425-109416426(+) m6A 5'UTR//exon       22608085
chr6:109416477-109416478(+) m6A 5'UTR//exon//intron       22608085
chr6:109416494-109416495(+) m6A 5'UTR//exon//intron       24981863//22608085
chr6:109416526-109416527(+) m6A 5'UTR//exon//intron       24981863
chr6:109468041-109468042(+) m6A 5'UTR//CDS//exon//intron       24981863
chr6:109468091-109468092(+) m6A 5'UTR//CDS//exon//intron       24981863
chr6:109471422-109471423(+) m6A CDS//exon       24981863
chr6:109471435-109471436(+) m6A CDS//exon       24981863
chr6:109475058-109475059(+) m6A CDS//exon       24981863
chr6:109480623-109480624(+) m6A 3'UTR//CDS//exon       24981863
chr6:109480652-109480653(+) m6A 3'UTR//CDS       24981863
chr6:109481786-109481787(+) m6A 3'UTR//CDS       24981863//27773535//22608085
chr6:109481795-109481796(+) m6A 3'UTR//CDS       24981863//27773535//22608085
chr6:109481808-109481809(+) m6A 3'UTR//CDS       24981863//27773535//22608085
chr6:109481846-109481847(+) m6A 3'UTR//CDS       24981863//27773535//22608085
chr6:109481885-109481886(+) m6A CDS       24981863//27773535//22608085
chr6:109481897-109481898(+) m6A CDS       24981863//27773535//22608085
chr6:109481914-109481915(+) m6A CDS       24981863//27773535//22608085
chr6:109481952-109481953(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085
chr6:109483959-109483960(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr6:109483979-109483980(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr6:109484018-109484019(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr6:109484042-109484043(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr6:109484096-109484097(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr6:109484166-109484167(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr6:109484177-109484178(+) m6A 3'UTR       24284625//24981863//27773535//22608085
chr6:109484185-109484186(+) m6A 3'UTR       24284625//24981863//27773535//22608085
chr6:109484201-109484202(+) m6A 3'UTR       24284625//24981863//27773535//22608085
chr6:109484215-109484216(+) m6A 3'UTR       24981863//27773535//22608085
chr6:109484291-109484292(+) m6A 3'UTR       24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-3607-3p
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Microvesicle Fibroblasts|Mesenchymal stem cells     -
CEP57L1
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus K562 cells     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-3607-3p
Gemcitabine 60750 Drug interaction    RC00008306
5-Fluorouracil 3385 Drug interaction    RC00008305
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00008304
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00008307
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-3607-3p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-3607-3p
Interactor2: CEP57L1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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