Detail Information

Basic Information:


  VIRBase ID:  

HHID00073007

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-3607-3p PIGW
miRBase
Accession/Entrez ID		 MIMAT0017985 284098
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - Gwt1//HPMRS5

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PIGW
chr17:34891606(+) A-I      intronic
chr17:34894622(+) A-I      3'UTR
chr17:34894775(+) A-I      3'UTR
chr17:34891605(+) A-I      intronic
chr17:34894878(+) A-I      3'UTR
chr17:34894866(+) A-I      3'UTR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PIGW
chr17:34890990-34890991(+) m6A 5'UTR//intron       24209618//25456834//24981863//27371828
chr17:34891087-34891088(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//27371828//22608085
chr17:34891219-34891220(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr17:34891246-34891247(+) m6A 5'UTR//intron       24284625//24209618//25456834//24981863//22575960//22608085
chr17:34891408-34891409(+) m6A 5'UTR//intron       24284625//24209618//22608085
chr17:34892998-34892999(+) m6A CDS       24284625//24209618//24981863//22608085
chr17:34893112-34893113(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr17:34893253-34893254(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr17:34893267-34893268(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr17:34893302-34893303(+) m6A CDS       24284625//24209618//24981863//22575960//22608085
chr17:34893392-34893393(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr17:34893424-34893425(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr17:34893439-34893440(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085
chr17:34893551-34893552(+) m6A CDS       24284625//24209618//24981863//22608085
chr17:34893630-34893631(+) m6A CDS       24209618//24981863//22608085
chr17:34893659-34893660(+) m6A CDS       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-3607-3p
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Microvesicle Fibroblasts|Mesenchymal stem cells     -
PIGW
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-3607-3p
Gemcitabine 60750 Drug interaction    RC00008306
5-Fluorouracil 3385 Drug interaction    RC00008305
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00008304
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00008307
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-3607-3p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-3607-3p
Interactor2: PIGW

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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