Detail Information

Basic Information:


  VIRBase ID:  

HHID00072994

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-3607-3p LYPLAL1
miRBase
Accession/Entrez ID		 MIMAT0017985 127018
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - Q96AV0

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR LYPLAL1
chr1:219376238(+) A-I      intronic
chr1:219376151(+) A-I      intronic
chr1:219376043(+) A-I      intronic
chr1:219376040(+) A-I      intronic
chr1:219376145(+) A-I      intronic
chr1:219376041(+) A-I      intronic
chr1:219376157(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED LYPLAL1
chr1:219383941(+) A-G exon CDS    21725310
chr1:219372963(+) C-T intron -    22484847
chr1:219376151(+) A-G intron -    22484847
chr1:219376157(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase LYPLAL1
chr1:219347205-219347206(+) m6A 5'UTR       24981863
chr1:219347365-219347366(+) m6A exon//intron       24981863
chr1:219347628-219347629(+) m6A exon//intron       24981863
chr1:219348327-219348328(+) m6A exon//intron       24981863
chr1:219352498-219352499(+) m6A CDS//exon       24981863
chr1:219384923-219384924(+) m6A CDS//exon       27773535
chr1:219385001-219385002(+) m6A CDS//exon       24981863//27773535
chr1:219385011-219385012(+) m6A CDS//exon       24981863//27773535
chr1:219385060-219385061(+) m6A CDS//exon       24981863//27773535
chr1:219385152-219385153(+) Y 3'UTR//exon       26075521

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-3607-3p
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Microvesicle Fibroblasts|Mesenchymal stem cells     -
LYPLAL1
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-3607-3p
Gemcitabine 60750 Drug interaction    RC00008306
5-Fluorouracil 3385 Drug interaction    RC00008305
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00008304
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00008307
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-3607-3p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-3607-3p
Interactor2: LYPLAL1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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