Detail Information

Basic Information:


  VIRBase ID:  

HHID00072991

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-3607-3p CYP2U1
miRBase
Accession/Entrez ID		 MIMAT0017985 113612
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - P450TEC//SPG49//SPG56

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR CYP2U1
chr4:108861353(+) A-I      intronic
chr4:108860242(+) A-I      intronic
chr4:108860064(+) A-I      intronic
chr4:108861315(+) A-I      intronic
chr4:108861348(+) A-I      intronic
chr4:108861329(+) A-I      intronic
chr4:108861310(+) A-I      intronic
chr4:108861305(+) A-I      intronic
chr4:108865478(+) A-I      intronic
chr4:108865599(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase CYP2U1
chr4:108852717-108852718(+) m6A 5'UTR       24981863
chr4:108852774-108852775(+) m6A 5'UTR//exon       24981863
chr4:108852796-108852797(+) m6A 5'UTR//exon       24981863
chr4:108852836-108852837(+) m6A 5'UTR//CDS//exon       -
chr4:108866281-108866282(+) m6A CDS       22608085
chr4:108866425-108866426(+) m6A CDS       24284625//24981863//22608085
chr4:108866480-108866481(+) m6A CDS       24284625//24981863//22608085
chr4:108866498-108866499(+) m6A CDS       24284625//24981863//22608085
chr4:108866545-108866546(+) m6A CDS       24284625//24981863//22608085
chr4:108866572-108866573(+) m6A CDS       24284625//24981863//22608085
chr4:108866581-108866582(+) m6A CDS       24284625//24981863//22608085
chr4:108866590-108866591(+) m6A CDS       24284625//24981863//22608085
chr4:108866694-108866695(+) m6A CDS       24284625//24981863//22608085
chr4:108866746-108866747(+) m6A CDS       24284625//24981863//22608085
chr4:108868591-108868592(+) m6A CDS       24284625//22608085
chr4:108871422-108871423(+) m6A CDS       24981863//22608085
chr4:108871656-108871657(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr4:108871805-108871806(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr4:108871892-108871893(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr4:108871922-108871923(+) m6A 3'UTR       24284625//24981863//22608085
chr4:108872015-108872016(+) m6A 3'UTR       24284625//24981863//22608085
chr4:108872053-108872054(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr4:108872134-108872135(+) m6A 3'UTR       24981863//22608085
chr4:108872240-108872241(+) m6A 3'UTR       22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-3607-3p
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Microvesicle Fibroblasts|Mesenchymal stem cells     -
CYP2U1
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-3607-3p
Gemcitabine 60750 Drug interaction    RC00008306
5-Fluorouracil 3385 Drug interaction    RC00008305
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00008304
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00008307
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-3607-3p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-3607-3p
Interactor2: CYP2U1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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