Detail Information

Basic Information:


  VIRBase ID:  

HHID00072978

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-3607-3p PDCD1LG2
miRBase
Accession/Entrez ID		 MIMAT0017985 80380
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - B7DC//bA574F11.2//Btdc//CD273//PD-L2//PDCD1L2//PDL2

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PDCD1LG2
chr9:5526621(+) A-I      intronic
chr9:5526461(+) A-I      intronic
chr9:5525270(+) A-I      intronic
chr9:5515736(+) A-I      intronic
chr9:5528519(+) A-I      intronic
chr9:5515751(+) A-I      intronic
chr9:5515771(+) A-I      intronic
chr9:5515776(+) A-I      intronic
chr9:5515838(+) A-I      intronic
chr9:5515843(+) A-I      intronic
chr9:5515918(+) A-I      intronic
chr9:5526538(+) A-I      intronic
chr9:5516152(+) A-I      intronic
chr9:5515816(+) A-I      intronic
chr9:5526658(+) A-I      intronic
chr9:5526571(+) A-I      intronic
chr9:5525265(+) A-I      intronic
chr9:5526567(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PDCD1LG2
chr9:5525265(+) A-I intron -    22327324

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PDCD1LG2
chr9:5534982-5534983(+) m6A CDS       24981863
chr9:5535020-5535021(+) m6A CDS       24981863
chr9:5549352-5549353(+) m6A CDS       24981863
chr9:5549378-5549379(+) m6A CDS       24981863
chr9:5563174-5563175(+) m6A CDS       24981863
chr9:5563203-5563204(+) m6A CDS       24981863
chr9:5569959-5569960(+) m6A 3'UTR       24981863
chr9:5570014-5570015(+) m6A 3'UTR       24981863
chr9:5570021-5570022(+) m6A 3'UTR       24981863
chr9:5570099-5570100(+) m6A 3'UTR       24209618//24981863
chr9:5570111-5570112(+) m6A 3'UTR       24209618//24981863
chr9:5570134-5570135(+) m6A 3'UTR       24209618//24981863
chr9:5570156-5570157(+) m6A 3'UTR       24209618//24981863
chr9:5570227-5570228(+) m6A 3'UTR       24209618//24981863
chr9:5570264-5570265(+) m6A 3'UTR       24209618//24981863
chr9:5570349-5570350(+) m6A 3'UTR       24981863
chr9:5570418-5570419(+) m6A 3'UTR       24981863
chr9:5570433-5570434(+) m6A 3'UTR       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-3607-3p
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Microvesicle Fibroblasts|Mesenchymal stem cells     -
PDCD1LG2
Exosome Blood     -

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-3607-3p
Gemcitabine 60750 Drug interaction    RC00008306
5-Fluorouracil 3385 Drug interaction    RC00008305
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00008304
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00008307
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-3607-3p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-3607-3p
Interactor2: PDCD1LG2

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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