Detail Information

Basic Information:


  VIRBase ID:  

HHID00072974

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-3607-3p RPF1
miRBase
Accession/Entrez ID		 MIMAT0017985 80135
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - BXDC5

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RPF1
chr1:84959074(+) A-I      intronic
chr1:84959056(+) A-I      intronic
chr1:84959110(+) A-I      intronic
chr1:84959128(+) A-I      intronic
chr1:84952059(+) A-I      intronic
chr1:84952021(+) A-I      intronic
chr1:84950486(+) A-I      intronic
chr1:84950502(+) A-I      intronic
chr1:84952113(+) A-I      intronic
chr1:84950607(+) A-I      intronic
chr1:84952002(+) A-I      intronic
chr1:84950578(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RPF1
chr1:84944961-84944962(+) m6A 5'UTR       24284625//24209618//25456834//24981863//27773535//22608085
chr1:84945035-84945036(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr1:84945139-84945140(+) m6A CDS       24981863//22575960
chr1:84945176-84945177(+) m6A CDS       24981863//27773535
chr1:84946661-84946662(+) m6A CDS       24981863//27773535
chr1:84948621-84948622(+) m6A CDS       24981863//27773535
chr1:84948651-84948652(+) m6A CDS       24981863
chr1:84948661-84948662(+) m6A CDS       24981863
chr1:84961965-84961966(+) m6A CDS       27773535
chr1:84961971-84961972(+) m6A CDS       27773535
chr1:84962011-84962012(+) m6A CDS       27773535
chr1:84963185-84963186(+) m6A 3'UTR       26404942//27773535
chr1:84963200-84963201(+) m6A 3'UTR       26404942//27773535
chr1:84963261-84963262(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-3607-3p
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Microvesicle Fibroblasts|Mesenchymal stem cells     -
RPF1
Chromatin K562 cells     -
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-3607-3p
Gemcitabine 60750 Drug interaction    RC00008306
5-Fluorouracil 3385 Drug interaction    RC00008305
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00008304
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00008307
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-3607-3p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-3607-3p
Interactor2: RPF1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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