Detail Information

Basic Information:


  VIRBase ID:  

HHID00072971

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-3607-3p MIER1
miRBase
Accession/Entrez ID		 MIMAT0017985 57708
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - ER1//MI-ER1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR MIER1
chr1:67441095(+) A-I      intronic
chr1:67402125(+) A-I      intronic
chr1:67441116(+) A-I      intronic
chr1:67441054(+) A-I      intronic
chr1:67402105(+) A-I      intronic
chr1:67443693(+) A-I      intronic
chr1:67443684(+) A-I      intronic
chr1:67421954(+) A-I      intronic
chr1:67421953(+) A-I      intronic
chr1:67441051(+) A-I      intronic
chr1:67403093(+) A-I      intronic
chr1:67405212(+) A-I      intronic
chr1:67440938(+) A-I      intronic
chr1:67402506(+) A-I      intronic
chr1:67430269(+) A-I      intronic
chr1:67430261(+) A-I      intronic
chr1:67430236(+) A-I      intronic
chr1:67430229(+) A-I      intronic
chr1:67430192(+) A-I      intronic
chr1:67411359(+) A-I      intronic
chr1:67402623(+) A-I      intronic
chr1:67403196(+) A-I      intronic
chr1:67429370(+) A-I      intronic
chr1:67429947(+) A-I      intronic
chr1:67402607(+) A-I      intronic
chr1:67402020(+) A-I      intronic
chr1:67402028(+) A-I      intronic
chr1:67402610(+) A-I      intronic
chr1:67402642(+) A-I      intronic
chr1:67403188(+) A-I      intronic
chr1:67402420(+) A-I      intronic
chr1:67402422(+) A-I      intronic
chr1:67402467(+) A-I      intronic
chr1:67403194(+) A-I      intronic
chr1:67402584(+) A-I      intronic
chr1:67402603(+) A-I      intronic
chr1:67415909(+) A-I      intronic
chr1:67421856(+) A-I      intronic
chr1:67421939(+) A-I      intronic
chr1:67421952(+) A-I      intronic
chr1:67421957(+) A-I      intronic
chr1:67429884(+) A-I      intronic
chr1:67429872(+) A-I      intronic
chr1:67429854(+) A-I      intronic
chr1:67429523(+) A-I      intronic
chr1:67429516(+) A-I      intronic
chr1:67429512(+) A-I      intronic
chr1:67429487(+) A-I      intronic
chr1:67429435(+) A-I      intronic
chr1:67429404(+) A-I      intronic
chr1:67429401(+) A-I      intronic
chr1:67421989(+) A-I      intronic
chr1:67441052(+) A-I      intronic
chr1:67441112(+) A-I      intronic
chr1:67442990(+) A-I      intronic
chr1:67442999(+) A-I      intronic
chr1:67443703(+) A-I      intronic
chr1:67443002(+) A-I      intronic
chr1:67441218(+) A-I      intronic
chr1:67402096(+) A-I      intronic
chr1:67411338(+) A-I      intronic
chr1:67445577(+) A-I      intronic
chr1:67403272(+) A-I      intronic
chr1:67422006(+) A-I      intronic
chr1:67417396(+) A-I      intronic
chr1:67421981(+) A-I      intronic
chr1:67411386(+) A-I      intronic
chr1:67441019(+) A-I      intronic
chr1:67443804(+) A-I      intronic
chr1:67443626(+) A-I      intronic
chr1:67445557(+) A-I      intronic
chr1:67429346(+) A-I      intronic
chr1:67441702(+) A-I      intronic
chr1:67403013(+) A-I      intronic
chr1:67403060(+) A-I      intronic
chr1:67402555(+) A-I      intronic
chr1:67443829(+) A-I      intronic
chr1:67402475(+) A-I      intronic
chr1:67443627(+) A-I      intronic
chr1:67402472(+) A-I      intronic
chr1:67429967(+) A-I      intronic
chr1:67403268(+) A-I      intronic
chr1:67403036(+) A-I      intronic
chr1:67429941(+) A-I      intronic
chr1:67442857(+) A-I      intronic
chr1:67411366(+) A-I      intronic
chr1:67429484(+) A-I      intronic
chr1:67442910(+) A-I      intronic
chr1:67421951(+) A-I      intronic
chr1:67402561(+) A-I      intronic
chr1:67429978(+) A-I      intronic
chr1:67430018(+) A-I      intronic
chr1:67402116(+) A-I      intronic
chr1:67402602(+) A-I      intronic
chr1:67429426(+) A-I      intronic
chr1:67420531(+) A-I      intronic
chr1:67429470(+) A-I      intronic
chr1:67411344(+) A-I      intronic
chr1:67410592(+) A-I      intronic
chr1:67417050(+) A-I      intronic
chr1:67421946(+) A-I      intronic
chr1:67410467(+) A-I      intronic
chr1:67429855(+) A-I      intronic
chr1:67429511(+) A-I      intronic
chr1:67421945(+) A-I      intronic
chr1:67420666(+) A-I      intronic
chr1:67411363(+) A-I      intronic
chr1:67403055(+) A-I      intronic
chr1:67442862(+) A-I      intronic
chr1:67445501(+) A-I      intronic
chr1:67403148(+) A-I      intronic
chr1:67416978(+) A-I      intronic
chr1:67403094(+) A-I      intronic
chr1:67442893(+) A-I      intronic
chr1:67402184(+) A-I      intronic
chr1:67429471(+) A-I      intronic
chr1:67417348(+) A-I      intronic
chr1:67399845(+) A-I      intronic
chr1:67402496(+) A-I      intronic
chr1:67429415(+) A-I      intronic
chr1:67441063(+) A-I      intronic
chr1:67429579(+) A-I      intronic
chr1:67409312(+) A-I      intronic
chr1:67441031(+) A-I      intronic
chr1:67422049(+) A-I      intronic
chr1:67421983(+) A-I      intronic
chr1:67402627(+) A-I      intronic
chr1:67403147(+) A-I      intronic
chr1:67429979(+) A-I      intronic
chr1:67429777(+) A-I      intronic
chr1:67402434(+) A-I      intronic
chr1:67402032(+) A-I      intronic
chr1:67429431(+) A-I      intronic
chr1:67402099(+) A-I      intronic
chr1:67420445(+) A-I      intronic
chr1:67429943(+) A-I      intronic
chr1:67421867(+) A-I      intronic
chr1:67409288(+) A-I      intronic
chr1:67429476(+) A-I      intronic
chr1:67403014(+) A-I      intronic
chr1:67429338(+) A-I      intronic
chr1:67403063(+) A-I      intronic
chr1:67429506(+) A-I      intronic
chr1:67400110(+) A-I      intronic
chr1:67429405(+) A-I      intronic
chr1:67450795(+) A-I      3'UTR
chr1:67442976(+) A-I      intronic
chr1:67401986(+) A-I      intronic
chr1:67402507(+) A-I      intronic
chr1:67422052(+) A-I      intronic
chr1:67443054(+) A-I      intronic
chr1:67442872(+) A-I      intronic
chr1:67430262(+) A-I      intronic
chr1:67429894(+) A-I      intronic
chr1:67403153(+) A-I      intronic
chr1:67402428(+) A-I      intronic
chr1:67402429(+) A-I      intronic
chr1:67443758(+) A-I      intronic
chr1:67441103(+) A-I      intronic
chr1:67443756(+) A-I      intronic
chr1:67429429(+) A-I      intronic
chr1:67402029(+) A-I      intronic
chr1:67401985(+) A-I      intronic
chr1:67441059(+) A-I      intronic
chr1:67402632(+) A-I      intronic
chr1:67443720(+) A-I      intronic
chr1:67441220(+) A-I      intronic
chr1:67403218(+) A-I      intronic
chr1:67402178(+) A-I      intronic
chr1:67402190(+) A-I      intronic
chr1:67421948(+) A-I      intronic
chr1:67401980(+) A-I      intronic
chr1:67429444(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MIER1
chr1:67402507(+) A-I intron -    22327324
chr1:67403014(+) A-I intron -    21960545
chr1:67400106(+) A-T intron -    22484847
chr1:67401980(+) A-G intron -    22484847
chr1:67401985(+) A-G intron -    22484847
chr1:67402029(+) A-G intron -    22484847
chr1:67402032(+) A-G intron -    22484847
chr1:67402116(+) A-G intron -    22484847
chr1:67402178(+) A-G intron -    22484847
chr1:67402184(+) A-G intron -    22484847
chr1:67402190(+) A-G intron -    22484847
chr1:67402428(+) A-G intron -    22484847
chr1:67402429(+) A-G intron -    22484847
chr1:67402434(+) A-G intron -    22484847
chr1:67402472(+) A-G intron -    22484847
chr1:67402507(+) A-G intron -    22484847
chr1:67402555(+) A-G intron -    22484847
chr1:67402561(+) A-G intron -    22484847
chr1:67403055(+) A-G intron -    22484847
chr1:67403060(+) A-G intron -    22484847
chr1:67403147(+) A-G intron -    22484847
chr1:67411366(+) A-G intron -    22484847
chr1:67417267(+) T-A intron -    22484847
chr1:67420445(+) A-G intron -    22484847
chr1:67420531(+) A-G intron -    22484847
chr1:67421925(+) T-C intron -    22484847
chr1:67421948(+) A-G intron -    22484847
chr1:67421951(+) A-G intron -    22484847
chr1:67421981(+) A-G intron -    22484847
chr1:67421983(+) A-G intron -    22484847
chr1:67422052(+) A-G intron -    22484847
chr1:67429338(+) A-G intron -    22484847
chr1:67429405(+) A-G intron -    22484847
chr1:67429415(+) A-G intron -    22484847
chr1:67429429(+) A-G intron -    22484847
chr1:67429431(+) A-G intron -    22484847
chr1:67429444(+) A-G intron -    22484847
chr1:67429470(+) A-G intron -    22484847
chr1:67429471(+) A-G intron -    22484847
chr1:67429476(+) A-G intron -    22484847
chr1:67429484(+) A-G intron -    22484847
chr1:67429495(+) T-G intron -    22484847
chr1:67429506(+) A-G intron -    22484847
chr1:67429511(+) A-G intron -    22484847
chr1:67429777(+) A-G intron -    22484847
chr1:67429855(+) A-G intron -    22484847
chr1:67429894(+) A-G intron -    22484847
chr1:67429941(+) A-G intron -    22484847
chr1:67429955(+) G-A intron -    22484847
chr1:67429979(+) A-G intron -    22484847
chr1:67435159(+) C-T intron -    22484847
chr1:67441063(+) A-G intron -    22484847
chr1:67441103(+) A-G intron -    22484847
chr1:67441220(+) A-G intron -    22484847
chr1:67442862(+) A-G intron -    22484847
chr1:67442910(+) A-G intron -    22484847
chr1:67442976(+) A-G intron -    22484847
chr1:67443002(+) A-G intron -    22484847
chr1:67443626(+) A-G intron -    22484847
chr1:67443627(+) A-G intron -    22484847
chr1:67445501(+) A-G intron -    22484847
chr1:67445557(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MIER1
chr1:67390648-67390649(+) m1A 5'UTR       26863196
chr1:67411942-67411943(+) m6A CDS//exon//intron       27773535
chr1:67411964-67411965(+) Am CDS//exon//intron       -
chr1:67423764-67423765(+) m6A CDS//exon       24981863//27773535//22575960
chr1:67424572-67424573(+) m6A CDS//exon       24981863//27773535
chr1:67425415-67425416(+) m6A CDS//exon       27773535
chr1:67425435-67425436(+) m6A exon//intron       27773535
chr1:67436520-67436521(+) m6A CDS       24981863//22575960
chr1:67436579-67436580(+) m6A CDS       24981863
chr1:67436631-67436632(+) m6A CDS       24981863
chr1:67436638-67436639(+) m6A CDS       24981863
chr1:67447541-67447542(+) m6A CDS       22608085
chr1:67450270-67450271(+) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:67450287-67450288(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:67450327-67450328(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:67450348-67450349(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:67450385-67450386(+) m6A CDS//intron       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr1:67450411-67450412(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr1:67450465-67450466(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr1:67450488-67450489(+) m6A CDS//intron       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr1:67450561-67450562(+) m6A CDS//intron       24284625//25456834//24981863//26404942//27773535//22608085
chr1:67450569-67450570(+) m6A CDS//intron       24284625//25456834//24981863//26404942//27773535//22608085
chr1:67450590-67450591(+) m6A 3'UTR//intron       26404942//22608085
chr1:67453590-67453591(+) m6A 3'UTR       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-3607-3p
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Microvesicle Fibroblasts|Mesenchymal stem cells     -
MIER1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -
Ribosome HEK-293 cells     22199352

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-3607-3p
Gemcitabine 60750 Drug interaction    RC00008306
5-Fluorouracil 3385 Drug interaction    RC00008305
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00008304
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00008307
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-3607-3p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-3607-3p
Interactor2: MIER1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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