Detail Information

Basic Information:


  VIRBase ID:  

HHID00072957

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-3607-3p KCTD5
miRBase
Accession/Entrez ID		 MIMAT0017985 54442
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - -

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR KCTD5
chr16:2739874(+) A-I      intronic
chr16:2734579(+) A-I      intronic
chr16:2734775(+) A-I      intronic
chr16:2734781(+) A-I      intronic
chr16:2734780(+) A-I      intronic
chr16:2734778(+) A-I      intronic
chr16:2734668(+) A-I      intronic
chr16:2735367(+) A-I      intronic
chr16:2738381(+) A-I      intronic
chr16:2738391(+) A-I      intronic
chr16:2734645(+) A-I      intronic
chr16:2734511(+) A-I      intronic
chr16:2739816(+) A-I      intronic
chr16:2742286(+) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase KCTD5
chr16:2732480-2732481(+) m6A 5'UTR       25456834//24981863
chr16:2732729-2732730(+) m6A CDS//exon       24284625
chr16:2732742-2732743(+) m6A CDS//exon       24284625
chr16:2732790-2732791(+) m6A CDS//exon       24284625
chr16:2732796-2732797(+) m6A CDS//exon       24284625
chr16:2745993-2745994(+) m6A CDS//exon       24981863
chr16:2746003-2746004(+) m6A CDS//exon       24981863
chr16:2746029-2746030(+) m6A CDS//exon       24981863
chr16:2752393-2752394(+) m6A CDS       24284625
chr16:2757331-2757332(+) m6A 3'UTR//CDS       24284625//24981863//27773535//22608085
chr16:2757383-2757384(+) m6A 3'UTR//CDS       24284625//24981863//22608085
chr16:2757418-2757419(+) m6A 3'UTR//CDS       24284625//24981863//22608085
chr16:2757600-2757601(+) m6A 3'UTR       24284625//25456834//24981863
chr16:2757610-2757611(+) m6A 3'UTR       24284625//25456834//24981863
chr16:2757940-2757941(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr16:2757980-2757981(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr16:2758008-2758009(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr16:2758059-2758060(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr16:2758329-2758330(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr16:2758393-2758394(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr16:2758416-2758417(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr16:2758443-2758444(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr16:2758461-2758462(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr16:2758502-2758503(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085
chr16:2758531-2758532(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085
chr16:2758599-2758600(+) m6A 3'UTR       24284625//25456834//24981863//22608085
chr16:2758665-2758666(+) m6A 3'UTR       24284625//25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-3607-3p
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Microvesicle Fibroblasts|Mesenchymal stem cells     -
KCTD5
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol K562 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-3607-3p
Gemcitabine 60750 Drug interaction    RC00008306
5-Fluorouracil 3385 Drug interaction    RC00008305
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00008304
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00008307
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-3607-3p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-3607-3p
Interactor2: KCTD5

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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