Detail Information

Basic Information:


  VIRBase ID:  

HHID00072894

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-3607-3p DEK
miRBase
Accession/Entrez ID		 MIMAT0017985 7913
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - D6S231E

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DEK
chr6:18238342(-) A-I      intronic
chr6:18250954(-) A-I      intronic
chr6:18257946(-) A-I      intronic
chr6:18257725(-) A-I      intronic
chr6:18238211(-) A-I      intronic
chr6:18238247(-) A-I      intronic
chr6:18254041(-) A-I      intronic
chr6:18254052(-) A-I      intronic
chr6:18238796(-) A-I      intronic
chr6:18238296(-) A-I      intronic
chr6:18238657(-) A-I      intronic
chr6:18238667(-) A-I      intronic
chr6:18254059(-) A-I      intronic
chr6:18254076(-) A-I      intronic
chr6:18238725(-) A-I      intronic
chr6:18238760(-) A-I      intronic
chr6:18254081(-) A-I      intronic
chr6:18238804(-) A-I      intronic
chr6:18238806(-) A-I      intronic
chr6:18238811(-) A-I      intronic
chr6:18238828(-) A-I      intronic
chr6:18239253(-) A-I      intronic
chr6:18239258(-) A-I      intronic
chr6:18239279(-) A-I      intronic
chr6:18240942(-) A-I      intronic
chr6:18240970(-) A-I      intronic
chr6:18242549(-) A-I      intronic
chr6:18250533(-) A-I      intronic
chr6:18250536(-) A-I      intronic
chr6:18238196(-) A-I      intronic
chr6:18238273(-) A-I      intronic
chr6:18254220(-) A-I      intronic
chr6:18254443(-) A-I      intronic
chr6:18254104(-) A-I      intronic
chr6:18238865(-) A-I      intronic
chr6:18241015(-) A-I      intronic
chr6:18242591(-) A-I      intronic
chr6:18238267(-) A-I      intronic
chr6:18239333(-) A-I      intronic
chr6:18238771(-) A-I      intronic
chr6:18239660(-) A-I      intronic
chr6:18238237(-) A-I      intronic
chr6:18256225(-) A-I      intronic
chr6:18238238(-) A-I      intronic
chr6:18241021(-) A-I      intronic
chr6:18257794(-) A-I      intronic
chr6:18238270(-) A-I      intronic
chr6:18238673(-) A-I      intronic
chr6:18226780(-) A-I      intronic
chr6:18238169(-) A-I      intronic
chr6:18238762(-) A-I      intronic
chr6:18250905(-) A-I      intronic
chr6:18250906(-) A-I      intronic
chr6:18248176(-) A-I      intronic
chr6:18242482(-) A-I      intronic
chr6:18239413(-) A-I      intronic
chr6:18238748(-) A-I      intronic
chr6:18238853(-) A-I      intronic
chr6:18248008(-) A-I      intronic
chr6:18238373(-) A-I      intronic
chr6:18238367(-) A-I      intronic
chr6:18226845(-) A-I      intronic
chr6:18239293(-) A-I      intronic
chr6:18238845(-) A-I      intronic
chr6:18250909(-) A-I      intronic
chr6:18239444(-) A-I      intronic
chr6:18226753(-) A-I      intronic
chr6:18226806(-) A-I      intronic
chr6:18238327(-) A-I      intronic
chr6:18250897(-) A-I      intronic
chr6:18238264(-) A-I      intronic
chr6:18240944(-) A-I      intronic
chr6:18242507(-) A-I      intronic
chr6:18239294(-) A-I      intronic
chr6:18254207(-) A-I      intronic
chr6:18252484(-) A-I      intronic
chr6:18238846(-) A-I      intronic
chr6:18254206(-) A-I      intronic
chr6:18242587(-) A-I      intronic
chr6:18250511(-) A-I      intronic
chr6:18235939(-) A-I      intronic
chr6:18226839(-) A-I      intronic
chr6:18248032(-) A-I      intronic
chr6:18238756(-) A-I      intronic
chr6:18238859(-) A-I      intronic
chr6:18254455(-) A-I      intronic
chr6:18238816(-) A-I      intronic
chr6:18238356(-) A-I      intronic
chr6:18254092(-) A-I      intronic
chr6:18254370(-) A-I      intronic
chr6:18253991(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DEK
chr6:18253404(-) A-G intron -    22484847
chr6:18238195(-) A-G intron -    22484847
chr6:18238327(-) A-G intron -    22484847
chr6:18238356(-) A-G intron -    22484847
chr6:18238367(-) A-G intron -    22484847
chr6:18238705(-) C-T intron -    22484847
chr6:18238756(-) A-G intron -    22484847
chr6:18238762(-) A-G intron -    22484847
chr6:18238765(-) A-G intron -    22484847
chr6:18238771(-) A-G intron -    22484847
chr6:18238816(-) A-G intron -    22484847
chr6:18238841(-) A-G intron -    22484847
chr6:18238842(-) A-G intron -    22484847
chr6:18238845(-) A-G intron -    22484847
chr6:18238846(-) A-G intron -    22484847
chr6:18239293(-) A-G intron -    22484847
chr6:18239294(-) A-G intron -    22484847
chr6:18239413(-) A-G intron -    22484847
chr6:18242507(-) A-G intron -    22484847
chr6:18248008(-) A-G intron -    22484847
chr6:18250511(-) A-G intron -    22484847
chr6:18253991(-) A-G intron -    22484847
chr6:18254206(-) A-G intron -    22484847
chr6:18254370(-) A-G intron -    22484847
chr6:18254450(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DEK
chr6:18224868-18224869(-) Gm 3'UTR       -
chr6:18224957-18224958(-) m6A 3'UTR       22575960
chr6:18225010-18225011(-) m6A 3'UTR       24981863//26404942//22575960
chr6:18225063-18225064(-) m6A 3'UTR       24981863//26404942//22575960
chr6:18225097-18225098(-) m6A 3'UTR       24981863//26404942
chr6:18225193-18225194(-) m6A 3'UTR       22575960
chr6:18225231-18225232(-) m6A 3'UTR       22575960
chr6:18225244-18225245(-) m6A 3'UTR       22575960
chr6:18225270-18225271(-) m6A 3'UTR       22575960
chr6:18225917-18225918(-) Tm 3'UTR       -
chr6:18225940-18225941(-) m6A 3'UTR       24981863//26404942//27773535
chr6:18226200-18226201(-) m6A 3'UTR//intron       27773535
chr6:18226206-18226207(-) m6A 3'UTR//intron       27773535
chr6:18226361-18226362(-) m6A 3'UTR//intron       24981863
chr6:18226418-18226419(-) m6A CDS       24981863//27773535
chr6:18236697-18236698(-) m6A CDS       24981863//28052920//27773535//22575960//22608085
chr6:18236747-18236748(-) m6A 3'UTR//CDS       24981863//28052920//27773535//22575960//22608085
chr6:18236775-18236776(-) m6A 3'UTR//CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr6:18236799-18236800(-) m6A 3'UTR//CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr6:18237367-18237368(-) m6A exon//intron       24284625//24981863//28052920//27773535//22608085
chr6:18237378-18237379(-) m6A exon//intron       24284625//24981863//28052920//27773535//22608085
chr6:18237406-18237407(-) m6A exon//intron       24981863//28052920//27773535//22608085
chr6:18237625-18237626(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22575960//22608085
chr6:18237711-18237712(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22575960//22608085
chr6:18237717-18237718(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22575960//22608085
chr6:18237734-18237735(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22575960//22608085
chr6:18244774-18244775(-) m6A CDS//intron       24981863//27773535//22608085
chr6:18244812-18244813(-) m6A CDS//intron       24981863//27773535
chr6:18249893-18249894(-) Am CDS//exon       -
chr6:18249927-18249928(-) m6A CDS//exon       24981863
chr6:18249985-18249986(-) m6A CDS//exon       24981863
chr6:18250017-18250018(-) m6A CDS//exon       24981863
chr6:18250048-18250049(-) m6A CDS//exon       24981863
chr6:18256012-18256013(-) m6A CDS//exon       22575960
chr6:18258207-18258208(-) m6A CDS       24981863//27773535
chr6:18258225-18258226(-) m6A CDS       24981863//27773535
chr6:18258233-18258234(-) m6A CDS       24981863//27773535
chr6:18258279-18258280(-) m6A CDS//intron       24209618//24981863//28052920//27773535//27371828
chr6:18264134-18264135(-) Cm CDS//intron       -
chr6:18264152-18264153(-) m6A CDS//intron       24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960
chr6:18264181-18264182(-) m6A CDS//intron       24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960
chr6:18264258-18264259(-) m6A 5'UTR//intron       24209618//25456834//24981863//27371828//27773536//22575960
chr6:18264371-18264372(-) m6A 5'UTR//intron       24209618//24981863//27773536//22575960
chr6:18264662-18264663(-) m6A 5'UTR       24209618//24981863//27371828//27773536//22575960
chr6:18264713-18264714(-) m6A 5'UTR       24209618//24981863//27371828//27773536//22575960
chr6:18264749-18264750(-) Y 5'UTR       25219674
chr6:18264777-18264778(-) m6A 5'UTR       24209618//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-3607-3p
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Microvesicle Fibroblasts|Mesenchymal stem cells     -
DEK
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-3607-3p
Gemcitabine 60750 Drug interaction    RC00008306
5-Fluorouracil 3385 Drug interaction    RC00008305
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00008304
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00008307
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-3607-3p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-3607-3p
Interactor2: DEK

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

Starting a new search, please wait ...