Detail Information

Basic Information:


  VIRBase ID:  

HHID00072886

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-3607-3p SOX9
miRBase
Accession/Entrez ID		 MIMAT0017985 6662
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CMD1//CMPD1//SRA1//SRXX2//SRXY10

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SOX9
chr17:70117184-70117185(+) m6A 5'UTR       24981863
chr17:70117195-70117196(+) m6A 5'UTR       24981863
chr17:70117212-70117213(+) m6A 5'UTR       24981863
chr17:70117235-70117236(+) m6A 5'UTR       24981863
chr17:70117351-70117352(+) m6A 5'UTR       24981863
chr17:70117617-70117618(+) m6A CDS       24284625//24981863
chr17:70117656-70117657(+) m6A CDS       24284625//24981863
chr17:70117665-70117666(+) m6A CDS       24284625//24981863
chr17:70117683-70117684(+) m6A CDS       24284625//24981863
chr17:70117731-70117732(+) m6A CDS       24981863
chr17:70117833-70117834(+) m6A CDS       -
chr17:70117905-70117906(+) m6A CDS       24209618
chr17:70118930-70118931(+) m6A CDS       24284625//24209618//24981863
chr17:70119724-70119725(+) m6A CDS       24209618
chr17:70119789-70119790(+) m6A CDS       -
chr17:70120337-70120338(+) m6A CDS       24284625//24209618//24981863
chr17:70120406-70120407(+) m6A CDS       24284625//24209618//24981863//22608085
chr17:70120471-70120472(+) m6A CDS       24284625//24209618//24981863//22608085
chr17:70120494-70120495(+) m6A CDS       24284625//24209618//24981863//22608085
chr17:70120592-70120593(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr17:70120613-70120614(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085
chr17:70120677-70120678(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr17:70120716-70120717(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:70120722-70120723(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:70120810-70120811(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:70120815-70120816(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:70120824-70120825(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr17:70120898-70120899(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-3607-3p
Exosome Plasma     23663360
Exosome B cell lymphoma cell lines|EBV-transformed lymphoblastoid B cells     25242326
Microvesicle Fibroblasts|Mesenchymal stem cells     -
SOX9
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-3607-3p
Gemcitabine 60750 Drug interaction    RC00008306
5-Fluorouracil 3385 Drug interaction    RC00008305
cis-Diaminedichloroplatinum 2767 Drug interaction    RC00008304
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00008307
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-3607-3p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-3607-3p
Interactor2: SOX9

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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