Basic Information:

  VIRBase ID:  

HHID00072785

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3194-5p:  MIMAT0015078          NSDHL:  NM_015922     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3194-5p	NSDHL
miRBase Accession/Entrez ID	MIMAT0015078	50814
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	H105E3//SDR31E1//XAP104

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3194-5p	rs1344875175 chr20:51452965    G/A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	NSDHL	chrX:152015675(+) A-I      intronic chrX:152015696(+) A-I      intronic chrX:152015718(+) A-I      intronic chrX:152015720(+) A-I      intronic chrX:152015804(+) A-I      intronic chrX:152023306(+) A-I      intronic chrX:152015716(+) A-I      intronic chrX:152032630(+) A-I      intronic chrX:152025521(+) A-I      intronic chrX:152023188(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NSDHL	chrX:151999639-151999640(+) m6A 5'UTR       24284625//24209618//24981863 chrX:152014850-152014851(+) m6A 5'UTR       24284625 chrX:152014873-152014874(+) m6A CDS       24284625 chrX:152014899-152014900(+) m6A CDS       27773535 chrX:152014913-152014914(+) m6A CDS       27773535 chrX:152014929-152014930(+) m6A CDS       27773535 chrX:152034441-152034442(+) m6A CDS       24284625 chrX:152036197-152036198(+) m6A CDS       24284625//24981863 chrX:152037366-152037367(+) m6A CDS       24284625//24981863 chrX:152037621-152037622(+) m6A CDS       24284625//24209618//25456834//24981863//22575960//22608085 chrX:152037663-152037664(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chrX:152037764-152037765(+) Y 3'UTR       26075521 chrX:152037826-152037827(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chrX:152037849-152037850(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chrX:152038119-152038120(+) m6A 3'UTR       24981863 chrX:152038145-152038146(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3194-5p	Exosome Serum     24683445 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Seminal plasma     23539611 Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	NSDHL	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3194-5p
Interactor2: NSDHL

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.