Detail Information

Basic Information:


  VIRBase ID:  

HHID00072683

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3187-3p:           RACK1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-3187-3p RACK1
miRBase
Accession/Entrez ID		 MIMAT0015069 10399
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - Gnb2-rs1//GNB2L1//H12.3//HLC-7//PIG21

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-3187-3p
rs1025138110 chr19:813643    G/A
rs1359317584 chr19:813638    G/A
rs1397804140 chr19:813642    C/T
rs769339066 chr19:813644    C/T
rs774945981 chr19:813645    G/A
rs867126287 chr19:813640    T/G
rs868127809 chr19:813636    G/T
rs912544725 chr19:813646    G/A
rs1028153194 chr19:813630    G/C
rs1173834237 chr19:813628    T/C
rs992822940 chr19:813632    C/T

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RACK1
chr5:180667784(-) A-I      intronic
chr5:180669832(-) A-I      intronic
chr5:180669779(-) A-I      intronic
chr5:180669815(-) A-I      intronic
chr5:180667722(-) A-I      intronic
chr5:180669620(-) A-I      intronic
chr5:180669634(-) A-I      intronic
chr5:180669664(-) A-I      intronic
chr5:180669715(-) A-I      intronic
chr5:180669736(-) A-I      intronic
chr5:180669763(-) A-I      intronic
chr5:180667957(-) A-I      ncRNA
chr5:180669695(-) A-I      intronic
chr5:180667912(-) A-I      intronic
chr5:180667894(-) A-I      intronic
chr5:180667778(-) A-I      intronic
chr5:180669834(-) A-I      intronic
chr5:180667800(-) A-I      intronic
chr5:180669666(-) A-I      intronic
chr5:180667733(-) A-I      intronic
chr5:180667404(-) A-I      intronic
chr5:180669786(-) A-I      intronic
chr5:180669772(-) A-I      intronic
chr5:180667966(-) A-I      ncRNA
chr5:180667961(-) A-I      ncRNA
chr5:180668002(-) A-I      ncRNA
chr5:180668041(-) A-I      ncRNA

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-3187-3p
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Seminal plasma     23539611
Microvesicle Fibroblasts|Mesenchymal stem cells     -
RACK1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome-free cytosol Colon cancer cells     24393600

Related Drug Information:


Resource Symbol Drug Name PubChem
ID		 Function Link  
RNAInter hsa-miR-3187-3p
Gemcitabine 60750 Drug interaction    RC00008135
5-Fluorouracil 3385 Drug interaction    RC00008134
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719 Drug interaction    RC00008136
Resource Symbol Drug Name PubChem ID PMID
NoncoRNA hsa-miR-3187-3p
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 24180719       26456124

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-3187-3p
Interactor2: RACK1

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region CDS
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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