Basic Information:

  VIRBase ID:  

HHID00072517

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3174:  MIMAT0015051          PPIL2:  NM_148175     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3174	PPIL2
miRBase Accession/Entrez ID	MIMAT0015051	23759
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CYC4//Cyp-60//CYP60//hCyP-60//UBOX7

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3174	rs1159846130 chr15:90006777    A/G rs1295514792 chr15:90006764    T/TGTTAGAGATGC rs775051847 chr15:90006779    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PPIL2	chr22:22044493(+) A-I      intronic chr22:22044416(+) A-I      intronic chr22:22045792(+) A-I      intronic chr22:22025886(+) A-I      intronic chr22:22045806(+) A-I      intronic chr22:22045809(+) A-I      intronic chr22:22047156(+) A-I      intronic chr22:22033713(+) A-I      intronic chr22:22033745(+) A-I      intronic chr22:22044514(+) A-I      intronic chr22:22044522(+) A-I      intronic chr22:22046965(+) A-I      intronic chr22:22009380(+) A-I      intronic chr22:22029731(+) A-I      intronic chr22:22032666(+) A-I      intronic chr22:22033141(+) A-I      intronic chr22:22033331(+) A-I      intronic chr22:22033687(+) A-I      intronic chr22:22034113(+) A-I      intronic chr22:22034741(+) A-I      intronic chr22:22034807(+) A-I      intronic chr22:22034946(+) A-I      intronic chr22:22034957(+) A-I      intronic chr22:22034972(+) A-I      intronic chr22:22034980(+) A-I      intronic chr22:22034992(+) A-I      intronic chr22:22035025(+) A-I      intronic chr22:22040277(+) A-I      intronic chr22:22044534(+) A-I      intronic chr22:22044607(+) A-I      intronic chr22:22045353(+) A-I      intronic chr22:22045430(+) A-I      intronic chr22:22045462(+) A-I      intronic chr22:22045480(+) A-I      intronic chr22:22045495(+) A-I      intronic chr22:22045720(+) A-I      intronic chr22:22045782(+) A-I      intronic chr22:22045797(+) A-I      intronic chr22:22045810(+) A-I      intronic chr22:22045822(+) A-I      intronic chr22:22045858(+) A-I      intronic chr22:22045862(+) A-I      intronic chr22:22045871(+) A-I      intronic chr22:22045903(+) A-I      intronic chr22:22045986(+) A-I      intronic chr22:22046538(+) A-I      intronic chr22:22046976(+) A-I      intronic chr22:22046982(+) A-I      intronic chr22:22047027(+) A-I      intronic chr22:22047052(+) A-I      intronic chr22:22047061(+) A-I      intronic chr22:22047063(+) A-I      intronic chr22:22047100(+) A-I      intronic chr22:22047160(+) A-I      intronic chr22:22047175(+) A-I      intronic chr22:22047180(+) A-I      intronic chr22:22047430(+) A-I      intronic chr22:22047463(+) A-I      intronic chr22:22047511(+) A-I      intronic chr22:22047546(+) A-I      intronic chr22:22008989(+) A-I      intronic chr22:22009072(+) A-I      intronic chr22:22009191(+) A-I      intronic chr22:22009360(+) A-I      intronic chr22:22009361(+) A-I      intronic chr22:22009369(+) A-I      intronic chr22:22009390(+) A-I      intronic chr22:22009498(+) A-I      intronic chr22:22009509(+) A-I      intronic chr22:22009531(+) A-I      intronic chr22:22010527(+) A-I      intronic chr22:22018616(+) A-I      intronic chr22:22018626(+) A-I      intronic chr22:22020921(+) A-I      intronic chr22:22033322(+) A-I      intronic chr22:22020951(+) A-I      intronic chr22:22021009(+) A-I      intronic chr22:22021018(+) A-I      intronic chr22:22022727(+) A-I      intronic chr22:22022728(+) A-I      intronic chr22:22023400(+) A-I      intronic chr22:22023520(+) A-I      intronic chr22:22023676(+) A-I      intronic chr22:22023821(+) A-I      intronic chr22:22026230(+) A-I      intronic chr22:22026242(+) A-I      intronic chr22:22029646(+) A-I      intronic chr22:22029704(+) A-I      intronic chr22:22044602(+) A-I      intronic chr22:22034640(+) A-I      intronic chr22:22034825(+) A-I      intronic chr22:22026084(+) A-I      intronic chr22:22047598(+) A-I      intronic chr22:22010587(+) A-I      intronic chr22:22019967(+) A-I      intronic chr22:22047004(+) A-I      intronic chr22:22045818(+) A-I      intronic chr22:22010490(+) A-I      intronic chr22:22047130(+) A-I      intronic chr22:22045485(+) A-I      intronic chr22:22033708(+) A-I      intronic chr22:22009182(+) A-I      intronic chr22:22047108(+) A-I      intronic chr22:22044608(+) A-I      intronic chr22:22033702(+) A-I      intronic chr22:22045819(+) A-I      intronic chr22:22009543(+) A-I      intronic chr22:22009400(+) A-I      intronic chr22:22044417(+) A-I      intronic chr22:22023399(+) A-I      intronic chr22:22034122(+) A-I      intronic chr22:22045523(+) A-I      intronic chr22:22010053(+) A-I      intronic chr22:22047406(+) A-I      intronic chr22:22033083(+) A-I      intronic chr22:22044410(+) A-I      intronic chr22:22022232(+) A-I      intronic chr22:22010054(+) A-I      intronic chr22:22034998(+) A-I      intronic chr22:22046719(+) A-I      intronic chr22:22047068(+) A-I      intronic chr22:22046571(+) A-I      intronic chr22:22044465(+) A-I      intronic chr22:22033077(+) A-I      intronic chr22:22009628(+) A-I      intronic chr22:22046986(+) A-I      intronic chr22:22025931(+) A-I      intronic chr22:22045382(+) A-I      intronic chr22:22009124(+) A-I      intronic chr22:22022839(+) A-I      intronic chr22:22045914(+) A-I      intronic chr22:22046726(+) A-I      intronic chr22:22021719(+) A-I      intronic chr22:22009090(+) A-I      intronic chr22:22010387(+) A-I      intronic chr22:22045959(+) A-I      intronic chr22:22033325(+) A-I      intronic chr22:22040249(+) A-I      intronic chr22:22010093(+) A-I      intronic chr22:22046610(+) A-I      intronic chr22:22045980(+) A-I      intronic chr22:22045965(+) A-I      intronic chr22:22047613(+) A-I      intronic chr22:22010216(+) A-I      intronic chr22:22033286(+) A-I      intronic chr22:22018921(+) A-I      intronic chr22:22017345(+) A-I      intronic chr22:22046717(+) A-I      intronic chr22:22009015(+) A-I      intronic chr22:22044443(+) A-I      intronic chr22:22044523(+) A-I      intronic chr22:22010083(+) A-I      intronic chr22:22045901(+) A-I      intronic chr22:22009575(+) A-I      intronic chr22:22044679(+) A-I      intronic chr22:22040181(+) A-I      intronic chr22:22026237(+) A-I      intronic chr22:22047136(+) A-I      intronic chr22:22045372(+) A-I      intronic chr22:22023893(+) A-I      intronic chr22:22046960(+) A-I      intronic chr22:22009298(+) A-I      intronic chr22:22010188(+) A-I      intronic chr22:22046937(+) A-I      intronic chr22:22013354(+) A-I      intronic chr22:22045494(+) A-I      intronic chr22:22009455(+) A-I      intronic chr22:22047537(+) A-I      intronic chr22:22040204(+) A-I      intronic chr22:22047401(+) A-I      intronic chr22:22046584(+) A-I      intronic chr22:22033536(+) A-I      intronic chr22:22046609(+) A-I      intronic chr22:22046628(+) A-I      intronic chr22:22045416(+) A-I      intronic chr22:22033923(+) A-I      intronic chr22:22047534(+) A-I      intronic chr22:22022328(+) A-I      intronic chr22:22009456(+) A-I      intronic chr22:22023972(+) A-I      intronic chr22:22033703(+) A-I      intronic chr22:22046574(+) A-I      intronic chr22:22010501(+) A-I      intronic chr22:22009405(+) A-I      intronic chr22:22022231(+) A-I      intronic chr22:22047482(+) A-I      intronic chr22:22017191(+) A-I      intronic chr22:22047104(+) A-I      intronic chr22:22009096(+) A-I      intronic chr22:22045390(+) A-I      intronic chr22:22034257(+) A-I      intronic chr22:22046625(+) A-I      intronic chr22:22047218(+) A-I      intronic chr22:22047520(+) A-I      intronic chr22:22044552(+) A-I      intronic chr22:22026111(+) A-I      intronic chr22:22047094(+) A-I      intronic chr22:22047135(+) A-I      intronic chr22:22033688(+) A-I      intronic chr22:22023324(+) A-I      intronic chr22:22010504(+) A-I      intronic chr22:22044526(+) A-I      intronic chr22:22009170(+) A-I      intronic chr22:22023928(+) A-I      intronic chr22:22045433(+) A-I      intronic chr22:22026220(+) A-I      intronic chr22:22009754(+) A-I      intronic chr22:22009572(+) A-I      intronic chr22:22038241(+) A-I      intronic chr22:22009532(+) A-I      intronic chr22:22034361(+) A-I      intronic chr22:22045692(+) A-I      intronic chr22:22045354(+) A-I      intronic chr22:22046959(+) A-I      intronic chr22:22009054(+) A-I      intronic chr22:22040203(+) A-I      intronic chr22:22025894(+) A-I      intronic chr22:22045422(+) A-I      intronic chr22:22040268(+) A-I      intronic chr22:22009411(+) A-I      intronic chr22:22026107(+) A-I      intronic chr22:22045741(+) A-I      intronic chr22:22009972(+) A-I      intronic chr22:22033991(+) A-I      intronic chr22:22034130(+) A-I      intronic chr22:22010545(+) A-I      intronic chr22:22023989(+) A-I      intronic chr22:22033514(+) A-I      intronic chr22:22045328(+) A-I      intronic chr22:22047526(+) A-I      intronic chr22:22009522(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PPIL2	chr22:22047406(+) A-I intron -    15258596 chr22:22047476(+) A-I intron -    15258596 chr22:22047482(+) A-I intron -    15258596 chr22:22047534(+) A-I intron -    15258596 chr22:22047537(+) A-I intron -    15258596 chr22:22047598(+) A-I intron -    15258596 chr22:22047599(+) A-I intron -    15258596 chr22:22045959(+) A-I intron -    22327324 chr22:22023185(+) A-G intron -    22484847 chr22:22023212(+) G-C intron -    22484847 chr22:22023928(+) A-G intron -    22484847 chr22:22044526(+) A-G intron -    22484847 chr22:22044552(+) A-G intron -    22484847 chr22:22045310(+) A-G intron -    22484847 chr22:22045333(+) A-G intron -    22484847 chr22:22045416(+) A-G intron -    22484847 chr22:22045433(+) A-G intron -    22484847 chr22:22047406(+) A-G intron -    22484847 chr22:22047462(+) A-G intron -    22484847 chr22:22047466(+) A-G intron -    22484847 chr22:22047476(+) A-G intron -    22484847 chr22:22047482(+) A-G intron -    22484847 chr22:22047537(+) A-G intron -    22484847 chr22:22047599(+) A-G intron -    22484847 chr22:22047613(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PPIL2	chr22:22015153-22015154(+) m6A exon       - chr22:22015162-22015163(+) m6A exon       - chr22:22015168-22015169(+) m6A exon       - chr22:22016334-22016335(+) m6A intron       22608085 chr22:22016399-22016400(+) m6A intron       25456834//22608085 chr22:22016414-22016415(+) m6A intron       25456834//22608085 chr22:22016435-22016436(+) m6A intron       25456834 chr22:22016457-22016458(+) m6A intron       25456834 chr22:22020413-22020414(+) m6A CDS//exon//intron       24284625 chr22:22023624-22023625(+) m6A CDS//intron       24284625 chr22:22029383-22029384(+) m6A 3'UTR//CDS//exon       - chr22:22029395-22029396(+) m6A 3'UTR//CDS//exon       - chr22:22036733-22036734(+) m6A 3'UTR//CDS//exon       - chr22:22036756-22036757(+) m6A 3'UTR//CDS//exon       - chr22:22036765-22036766(+) m6A 3'UTR//CDS//exon       - chr22:22036798-22036799(+) m6A 3'UTR//CDS//exon       - chr22:22037486-22037487(+) m6A 3'UTR//CDS//exon       24981863 chr22:22037540-22037541(+) m6A 3'UTR//CDS//exon       24981863 chr22:22039057-22039058(+) m6A 3'UTR//CDS//exon       24981863 chr22:22039062-22039063(+) m6A 3'UTR//CDS//exon       24981863 chr22:22039097-22039098(+) m6A 3'UTR//CDS//exon       24981863 chr22:22039106-22039107(+) m6A 3'UTR//CDS//exon       24981863 chr22:22039188-22039189(+) m6A 3'UTR//CDS       24981863 chr22:22040831-22040832(+) m6A 3'UTR//CDS//exon       24284625 chr22:22041940-22041941(+) m6A 3'UTR//CDS//exon       24284625 chr22:22041950-22041951(+) m6A 3'UTR//CDS//exon       24284625 chr22:22042013-22042014(+) m6A 3'UTR//CDS//exon       24284625 chr22:22048597-22048598(+) Cm intron       - chr22:22049010-22049011(+) m6A exon//intron       24981863 chr22:22049080-22049081(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr22:22049243-22049244(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr22:22049267-22049268(+) m6A 3'UTR//CDS//exon       24284625//24981863//27371828 chr22:22049315-22049316(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr22:22049762-22049763(+) m6A 3'UTR//CDS//exon       24284625//24981863 chr22:22049799-22049800(+) m6A 3'UTR//intron       24284625 chr22:22049985-22049986(+) m6A 3'UTR//intron       24284625 chr22:22050014-22050015(+) m6A 3'UTR//intron       24284625 chr22:22050098-22050099(+) m6A 3'UTR//intron       24284625 chr22:22050131-22050132(+) m6A 3'UTR//intron       24284625 chr22:22050321-22050322(+) m6A 3'UTR//intron       - chr22:22050373-22050374(+) m6A 3'UTR//intron       - chr22:22050385-22050386(+) m6A 3'UTR//intron       - chr22:22050392-22050393(+) m6A 3'UTR//intron       - chr22:22050445-22050446(+) m6A 3'UTR//intron       - chr22:22050546-22050547(+) m6A 3'UTR//intron       24284625 chr22:22050609-22050610(+) m6A 3'UTR//intron       24284625//24209618 chr22:22050648-22050649(+) m6A 3'UTR//intron       24284625//24209618//25456834 chr22:22050724-22050725(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863 chr22:22050795-22050796(+) m6A 3'UTR//intron       24284625//24209618//24981863 chr22:22050893-22050894(+) m6A 3'UTR//intron       24284625//24209618//24981863 chr22:22051026-22051027(+) m6A 3'UTR//intron       24284625//24209618 chr22:22051254-22051255(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr22:22051260-22051261(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr22:22051448-22051449(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr22:22051485-22051486(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr22:22051603-22051604(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr22:22051624-22051625(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr22:22051700-22051701(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr22:22051731-22051732(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr22:22051739-22051740(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr22:22051797-22051798(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr22:22051829-22051830(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr22:22051858-22051859(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr22:22051875-22051876(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr22:22051902-22051903(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr22:22052044-22052045(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr22:22052058-22052059(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr22:22052135-22052136(+) m6A 3'UTR//exon       24981863//27773535 chr22:22052620-22052621(+) m6A 3'UTR       22608085 chr22:22052631-22052632(+) m6A 3'UTR       22608085 chr22:22052661-22052662(+) m6A 3'UTR       22608085 chr22:22052672-22052673(+) m6A 3'UTR       22608085 chr22:22052692-22052693(+) m6A 3'UTR       25456834//22608085 chr22:22052710-22052711(+) m6A 3'UTR       25456834//22608085 chr22:22052771-22052772(+) m6A 3'UTR       25456834//24981863//27371828//22608085 chr22:22052814-22052815(+) m6A 3'UTR       24284625//25456834//24981863//27371828//22608085 chr22:22052882-22052883(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22608085 chr22:22052926-22052927(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22608085 chr22:22052977-22052978(+) m6A 3'UTR       24284625//25456834//24981863//27371828//22608085 chr22:22053049-22053050(+) m6A 3'UTR       27371828 chr22:22053121-22053122(+) m6A 3'UTR       27371828 chr22:22053437-22053438(+) m6A 3'UTR       27371828 chr22:22053538-22053539(+) m6A 3'UTR       27371828 chr22:22053585-22053586(+) m6A 3'UTR       27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3174	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Colon cancer cell line (LIM1863)|Fibroblasts|Mesenchymal stem cells     -
	PPIL2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3174
Interactor2: PPIL2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.