Basic Information:

  VIRBase ID:  

HHID00072290

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3150a-3p:  MIMAT0015023          TPP1:  NM_000391     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3150a-3p	TPP1
miRBase Accession/Entrez ID	MIMAT0015023	1200
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CLN2//GIG1//LPIC//SCAR7//TPP-1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3150a-3p	rs1005806635 chr8:95072962    C/CT rs372692847 chr8:95072962    C/T

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TPP1	chr11:6634085-6634086(-) m6A 3'UTR       27773535 chr11:6634571-6634572(-) m6A 3'UTR       24284625//24981863//28052920//27773535 chr11:6634581-6634582(-) m6A 3'UTR       24284625//24981863//28052920//27773535 chr11:6634637-6634638(-) m6A 3'UTR       24284625//24981863//27773535 chr11:6634701-6634702(-) m6A 3'UTR       24981863//27773535 chr11:6634840-6634841(-) m6A 3'UTR       24981863//27773535 chr11:6634971-6634972(-) m6A 3'UTR       24981863//27773535 chr11:6635031-6635032(-) m6A 3'UTR       24981863//27773535 chr11:6635113-6635114(-) m6A 3'UTR       27773535 chr11:6635157-6635158(-) m6A 3'UTR       27773535 chr11:6635370-6635371(-) m6A 3'UTR       24284625//27773535 chr11:6635415-6635416(-) m6A 3'UTR       24284625//27773535 chr11:6635466-6635467(-) m6A 3'UTR       24284625//27773535 chr11:6635664-6635665(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535 chr11:6635688-6635689(-) m6A 3'UTR       24284625//24209618//24981863//28052920//27773535 chr11:6635793-6635794(-) m6A 3'UTR//CDS       24284625//24981863//27773535 chr11:6635820-6635821(-) m6A CDS       24284625//24981863//27773535 chr11:6636105-6636106(-) m6A CDS//exon       24284625 chr11:6636166-6636167(-) Y CDS//exon       26075521 chr11:6636876-6636877(-) m6A exon//intron       27773535 chr11:6637267-6637268(-) m6A CDS//exon       27773535 chr11:6637871-6637872(-) m6A exon//intron       24284625//25456834//24981863//27773535 chr11:6637876-6637877(-) m6A exon//intron       24284625//25456834//24981863//27773535 chr11:6637991-6637992(-) m6A CDS//exon//intron       27773535 chr11:6638883-6638884(-) m6A 3'UTR//5'UTR//CDS//exon       24284625 chr11:6639837-6639838(-) m6A exon//intron       27773535 chr11:6639886-6639887(-) m6A exon//intron       27773535 chr11:6639910-6639911(-) m6A exon//intron       27773535 chr11:6639986-6639987(-) m6A 3'UTR//exon//intron       27371828 chr11:6639993-6639994(-) m6A 3'UTR//exon//intron       27371828 chr11:6640055-6640056(-) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//27371828 chr11:6640073-6640074(-) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//27371828 chr11:6640110-6640111(-) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24981863//27371828 chr11:6640214-6640215(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535//27371828 chr11:6640406-6640407(-) m6A 3'UTR//exon//intron       24284625//24981863//27773535 chr11:6640518-6640519(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//27371828 chr11:6640538-6640539(-) m6A 5'UTR//exon//intron       24284625//25456834//24981863//27371828 chr11:6640546-6640547(-) m6A 5'UTR//exon//intron       25456834//24981863//27371828 chr11:6640625-6640626(-) m6A CDS//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3150a-3p	Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	TPP1	Chromatin K562 cells     - Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleus HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3150a-3p
Interactor2: TPP1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.