Detail Information

Basic Information:


  VIRBase ID:  

HHID00072179

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-466:           MBNL3:      

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Interactor Information:


Interactor1 Interactor2
Symbol hsa-miR-466 MBNL3
miRBase
Accession/Entrez ID		 MIMAT0015002 55796
Organism Homo sapiens Homo sapiens
Category miRNA mRNA
Alias - CHCR//MBLX//MBLX39//MBXL

ncRNA SNP information:


Resource Symbol SNP ID SNP Position Ref/Alt
miRNASNP-v3 hsa-miR-466
rs1368640537 chr3:31161720    G/A
rs1392123954 chr3:31161725    G/A
rs1436733428 chr3:31161724    C/CGTGTAT
rs1460320210 chr3:31161721    T/C
rs148367480 chr3:31161715    T/G
rs540140185 chr3:31161736    T/C
rs548026272 chr3:31161724    C/T
rs1044765198 chr3:31161730    T/C
rs1055171867 chr3:31161731    G/C
rs116476604 chr3:31161729    A/G

RNA Editing:


Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED MBNL3
chrX:131568981(-) T-C intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase MBNL3
chrX:131503521-131503522(-) m6A 3'UTR       27773535//22608085
chrX:131503527-131503528(-) m6A 3'UTR       27773535//22575960//22608085
chrX:131503611-131503612(-) m6A 3'UTR       27773535//22575960//22608085
chrX:131503666-131503667(-) m6A 3'UTR       27773535//22608085
chrX:131503671-131503672(-) m6A 3'UTR       27773535//22608085
chrX:131503689-131503690(-) m6A 3'UTR       27773535//22608085
chrX:131503842-131503843(-) m6A 3'UTR       27773535
chrX:131503848-131503849(-) m6A 3'UTR       27773535
chrX:131503893-131503894(-) m6A 3'UTR       27773535
chrX:131507461-131507462(-) m6A 3'UTR       27773535
chrX:131513561-131513562(-) m6A 3'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate hsa-miR-466
Exosome Serum     18589210
Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     -
Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
MBNL3
Cytosol HCC cell line (HepG2)|HeLa-S3 cells     -
Exosome Blood     -
Membrane HCC cell line (HepG2)     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hsa-miR-466
Interactor2: MBNL3

Evidence Support:


Weak-Evidence PAR-CLIP
Support Database ViRBase

References:


PMID 22291592 Target region 3'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells Interactor2 expression None
Description We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.

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