Basic Information:

  VIRBase ID:  

HHID00072174

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-466:  MIMAT0015002          CORO1C:  NM_001276471     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-466	CORO1C
miRBase Accession/Entrez ID	MIMAT0015002	23603
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	HCRNN4

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-466	rs1368640537 chr3:31161720    G/A rs1392123954 chr3:31161725    G/A rs1436733428 chr3:31161724    C/CGTGTAT rs1460320210 chr3:31161721    T/C rs148367480 chr3:31161715    T/G rs540140185 chr3:31161736    T/C rs548026272 chr3:31161724    C/T rs1044765198 chr3:31161730    T/C rs1055171867 chr3:31161731    G/C rs116476604 chr3:31161729    A/G

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CORO1C	chr12:109104468(-) A-I      intronic chr12:109104484(-) A-I      intronic chr12:109104486(-) A-I      intronic chr12:109040613(-) A-I      3'UTR chr12:109100603(-) A-I      intronic chr12:109105346(-) A-I      intronic chr12:109105374(-) A-I      intronic chr12:109105429(-) A-I      intronic chr12:109109795(-) A-I      intronic chr12:109113717(-) A-I      intronic chr12:109113726(-) A-I      intronic chr12:109114424(-) A-I      intronic chr12:109104534(-) A-I      intronic chr12:109114432(-) A-I      intronic chr12:109106099(-) A-I      intronic chr12:109114464(-) A-I      intronic chr12:109114474(-) A-I      intronic chr12:109114477(-) A-I      intronic chr12:109114504(-) A-I      intronic chr12:109104518(-) A-I      intronic chr12:109119829(-) A-I      intronic chr12:109114566(-) A-I      intronic chr12:109104517(-) A-I      intronic chr12:109044820(-) A-I      intronic chr12:109044839(-) A-I      intronic chr12:109082881(-) A-I      intronic chr12:109045763(-) A-I      intronic chr12:109045799(-) A-I      intronic chr12:109045693(-) A-I      intronic chr12:109065011(-) A-I      intronic chr12:109099092(-) A-I      intronic chr12:109045714(-) A-I      intronic chr12:109099690(-) A-I      intronic chr12:109104511(-) A-I      intronic chr12:109120151(-) A-I      intronic chr12:109104973(-) A-I      intronic chr12:109064968(-) A-I      intronic chr12:109104605(-) A-I      intronic chr12:109104617(-) A-I      intronic chr12:109104472(-) A-I      intronic chr12:109104872(-) A-I      intronic chr12:109104876(-) A-I      intronic chr12:109099037(-) A-I      intronic chr12:109105199(-) A-I      intronic chr12:109105211(-) A-I      intronic chr12:109105344(-) A-I      intronic chr12:109081168(-) A-I      intronic chr12:109119701(-) A-I      intronic chr12:109119709(-) A-I      intronic chr12:109119783(-) A-I      intronic chr12:109119786(-) A-I      intronic chr12:109102813(-) A-I      intronic chr12:109119815(-) A-I      intronic chr12:109120119(-) A-I      intronic chr12:109102812(-) A-I      intronic chr12:109104935(-) A-I      intronic chr12:109102722(-) A-I      intronic chr12:109102511(-) A-I      intronic chr12:109102505(-) A-I      intronic chr12:109102488(-) A-I      intronic chr12:109102431(-) A-I      intronic chr12:109108416(-) A-I      intronic chr12:109102406(-) A-I      intronic chr12:109081369(-) A-I      intronic chr12:109102376(-) A-I      intronic chr12:109104595(-) A-I      intronic chr12:109102375(-) A-I      intronic chr12:109102349(-) A-I      intronic chr12:109105051(-) A-I      intronic chr12:109102268(-) A-I      intronic chr12:109100639(-) A-I      intronic chr12:109100484(-) A-I      intronic chr12:109099949(-) A-I      intronic chr12:109082552(-) A-I      intronic chr12:109099925(-) A-I      intronic chr12:109099881(-) A-I      intronic chr12:109099851(-) A-I      intronic chr12:109099841(-) A-I      intronic chr12:109045771(-) A-I      intronic chr12:109099153(-) A-I      intronic chr12:109088027(-) A-I      intronic chr12:109087884(-) A-I      intronic chr12:109082950(-) A-I      intronic chr12:109102747(-) A-I      intronic chr12:109082868(-) A-I      intronic chr12:109081960(-) A-I      intronic chr12:109081937(-) A-I      intronic chr12:109081858(-) A-I      intronic chr12:109081806(-) A-I      intronic chr12:109105414(-) A-I      intronic chr12:109081535(-) A-I      intronic chr12:109099160(-) A-I      intronic chr12:109044787(-) A-I      intronic chr12:109105046(-) A-I      intronic chr12:109100539(-) A-I      intronic chr12:109105324(-) A-I      intronic chr12:109044834(-) A-I      intronic chr12:109064964(-) A-I      intronic chr12:109102519(-) A-I      intronic chr12:109114371(-) A-I      intronic chr12:109102402(-) A-I      intronic chr12:109044746(-) A-I      intronic chr12:109102441(-) A-I      intronic chr12:109119790(-) A-I      intronic chr12:109120197(-) A-I      intronic chr12:109119679(-) A-I      intronic chr12:109108453(-) A-I      intronic chr12:109099919(-) A-I      intronic chr12:109045754(-) A-I      intronic chr12:109045701(-) A-I      intronic chr12:109099746(-) A-I      intronic chr12:109108928(-) A-I      intronic chr12:109105370(-) A-I      intronic chr12:109044833(-) A-I      intronic chr12:109065029(-) A-I      intronic chr12:109045749(-) A-I      intronic chr12:109044855(-) A-I      intronic chr12:109099797(-) A-I      intronic chr12:109064905(-) A-I      intronic chr12:109120201(-) A-I      intronic chr12:109105361(-) A-I      intronic chr12:109102275(-) A-I      intronic chr12:109104633(-) A-I      intronic chr12:109104956(-) A-I      intronic chr12:109082893(-) A-I      intronic chr12:109104882(-) A-I      intronic chr12:109120132(-) A-I      intronic chr12:109048657(-) A-I      intronic chr12:109044845(-) A-I      intronic chr12:109081914(-) A-I      intronic chr12:109114333(-) A-I      intronic chr12:109099154(-) A-I      intronic chr12:109045679(-) A-I      intronic chr12:109104610(-) A-I      intronic chr12:109104611(-) A-I      intronic chr12:109045718(-) A-I      intronic chr12:109065012(-) A-I      intronic chr12:109102583(-) A-I      intronic chr12:109108079(-) A-I      intronic chr12:109081837(-) A-I      intronic chr12:109098162(-) A-I      intronic chr12:109045719(-) A-I      intronic chr12:109100646(-) A-I      intronic chr12:109065094(-) A-I      intronic chr12:109045689(-) A-I      intronic chr12:109104451(-) A-I      intronic chr12:109098165(-) A-I      intronic chr12:109100655(-) A-I      intronic chr12:109102708(-) A-I      intronic chr12:109119791(-) A-I      intronic chr12:109044865(-) A-I      intronic chr12:109045715(-) A-I      intronic chr12:109064993(-) A-I      intronic chr12:109081824(-) A-I      intronic chr12:109045775(-) A-I      intronic chr12:109064926(-) A-I      intronic chr12:109082721(-) A-I      intronic chr12:109099098(-) A-I      intronic chr12:109082694(-) A-I      intronic chr12:109102806(-) A-I      intronic chr12:109113806(-) A-I      intronic chr12:109113805(-) A-I      intronic chr12:109054023(-) A-I      intronic chr12:109081959(-) A-I      intronic chr12:109042162(-) A-I      intronic chr12:109082567(-) A-I      intronic chr12:109099877(-) A-I      intronic chr12:109053971(-) A-I      intronic chr12:109120073(-) A-I      intronic chr12:109054011(-) A-I      intronic chr12:109045692(-) A-I      intronic chr12:109113862(-) A-I      intronic chr12:109119975(-) A-I      intronic chr12:109044193(-) A-I      intronic chr12:109113940(-) A-I      intronic chr12:109114563(-) A-I      intronic chr12:109064941(-) A-I      intronic chr12:109119777(-) A-I      intronic chr12:109081429(-) A-I      intronic chr12:109105334(-) A-I      intronic chr12:109044830(-) A-I      intronic chr12:109099880(-) A-I      intronic chr12:109104533(-) A-I      intronic chr12:109082724(-) A-I      intronic chr12:109120143(-) A-I      intronic chr12:109048576(-) A-I      intronic chr12:109120004(-) A-I      intronic chr12:109064945(-) A-I      intronic chr12:109112092(-) A-I      intronic chr12:109102803(-) A-I      intronic chr12:109081886(-) A-I      intronic chr12:109044106(-) A-I      intronic chr12:109105290(-) A-I      intronic chr12:109114438(-) A-I      intronic chr12:109081864(-) A-I      intronic chr12:109114395(-) A-I      intronic chr12:109119843(-) A-I      intronic chr12:109102693(-) A-I      intronic chr12:109105230(-) A-I      intronic chr12:109053125(-) A-I      intronic chr12:109100559(-) A-I      intronic chr12:109082684(-) A-I      intronic chr12:109119718(-) A-I      intronic chr12:109082555(-) A-I      intronic chr12:109055413(-) A-I      intronic chr12:109119792(-) A-I      intronic chr12:109099704(-) A-I      intronic chr12:109119724(-) A-I      intronic chr12:109104522(-) A-I      intronic chr12:109114558(-) A-I      intronic chr12:109081478(-) A-I      intronic chr12:109044856(-) A-I      intronic chr12:109120148(-) A-I      intronic chr12:109105060(-) A-I      intronic chr12:109113840(-) A-I      intronic chr12:109119727(-) A-I      intronic chr12:109081796(-) A-I      intronic chr12:109099149(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CORO1C	chr12:109044193(-) A-I intron -    15258596 chr12:109044830(-) A-I intron -    15258596   //22327324 chr12:109044833(-) A-I intron -    15258596 chr12:109044845(-) A-I intron -    22327324 chr12:109045715(-) A-I intron -    22327324 chr12:109044106(-) A-G intron -    22484847 chr12:109044830(-) A-G intron -    22484847 chr12:109044845(-) A-G intron -    22484847 chr12:109044856(-) A-G intron -    22484847 chr12:109045692(-) A-G intron -    22484847 chr12:109045715(-) A-G intron -    22484847 chr12:109045775(-) A-G intron -    22484847 chr12:109104610(-) A-G intron -    22484847 chr12:109044072(-) T-C intron -    22484847 chr12:109044839(-) A-G intron -    22484847 chr12:109044912(-) T-C intron -    22484847 chr12:109045680(-) T-C intron -    22484847 chr12:109045681(-) T-C intron -    22484847 chr12:109045701(-) A-G intron -    22484847 chr12:109045702(-) T-C intron -    22484847 chr12:109045714(-) A-G intron -    22484847 chr12:109045718(-) A-G intron -    22484847 chr12:109045749(-) A-G intron -    22484847 chr12:109048537(-) T-C intron -    22484847 chr12:109048543(-) T-C intron -    22484847 chr12:109048573(-) T-C intron -    22484847 chr12:109048579(-) T-C intron -    22484847 chr12:109053993(-) G-C intron -    22484847 chr12:109054025(-) C-G intron -    22484847 chr12:109065012(-) A-G intron -    22484847 chr12:109065094(-) A-G intron -    22484847 chr12:109070345(-) G-A intron -    22484847 chr12:109077029(-) C-T intron -    22484847 chr12:109077210(-) C-T intron -    22484847 chr12:109081478(-) A-G intron -    22484847 chr12:109081824(-) A-G intron -    22484847 chr12:109081837(-) A-G intron -    22484847 chr12:109081864(-) A-G intron -    22484847 chr12:109081914(-) A-G intron -    22484847 chr12:109081959(-) A-G intron -    22484847 chr12:109082555(-) A-G intron -    22484847 chr12:109082724(-) A-G intron -    22484847 chr12:109082808(-) C-T intron -    22484847 chr12:109082893(-) A-G intron -    22484847 chr12:109098162(-) A-G intron -    22484847 chr12:109098165(-) A-G intron -    22484847 chr12:109099037(-) A-G intron -    22484847 chr12:109099098(-) A-G intron -    22484847 chr12:109099877(-) A-G intron -    22484847 chr12:109099919(-) A-G intron -    22484847 chr12:109099981(-) G-T intron -    22484847 chr12:109100646(-) A-G intron -    22484847 chr12:109102402(-) A-G intron -    22484847 chr12:109102583(-) A-G intron -    22484847 chr12:109102806(-) A-G intron -    22484847 chr12:109104522(-) A-G intron -    22484847 chr12:109104533(-) A-G intron -    22484847 chr12:109104611(-) A-G intron -    22484847 chr12:109104633(-) A-G intron -    22484847 chr12:109105046(-) A-G intron -    22484847 chr12:109105051(-) A-G intron -    22484847 chr12:109105230(-) A-G intron -    22484847 chr12:109105290(-) A-G intron -    22484847 chr12:109105324(-) A-G intron -    22484847 chr12:109105361(-) A-G intron -    22484847 chr12:109105370(-) A-G intron -    22484847 chr12:109105414(-) A-G intron -    22484847 chr12:109106099(-) A-G intron -    22484847 chr12:109108079(-) A-G intron -    22484847 chr12:109108512(-) G-A intron -    22484847 chr12:109108928(-) A-G intron -    22484847 chr12:109113840(-) A-G intron -    22484847 chr12:109114438(-) A-G intron -    22484847 chr12:109114558(-) A-G intron -    22484847 chr12:109114563(-) A-G intron -    22484847 chr12:109119679(-) A-G intron -    22484847 chr12:109119724(-) A-G intron -    22484847 chr12:109119727(-) A-G intron -    22484847 chr12:109119777(-) A-G intron -    22484847 chr12:109119790(-) A-G intron -    22484847 chr12:109119791(-) A-G intron -    22484847 chr12:109119792(-) A-G intron -    22484847 chr12:109119975(-) A-G intron -    22484847 chr12:109120004(-) A-G intron -    22484847 chr12:109120132(-) A-G intron -    22484847 chr12:109120143(-) A-G intron -    22484847 chr12:109120148(-) A-G intron -    22484847 chr12:109120151(-) A-G intron -    22484847 chr12:109120197(-) A-G intron -    22484847 chr12:109120201(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CORO1C	chr12:109038927-109038928(-) m6A 3'UTR       24981863//26404942 chr12:109038982-109038983(-) m6A 3'UTR       24981863 chr12:109039449-109039450(-) m6A 3'UTR       26404942//22575960 chr12:109039478-109039479(-) m6A 3'UTR       26404942//22575960 chr12:109039539-109039540(-) m6A 3'UTR       26404942//22575960 chr12:109039586-109039587(-) m6A 3'UTR       26404942//22575960 chr12:109039657-109039658(-) m6A 3'UTR       26404942//22575960 chr12:109039699-109039700(-) m6A 3'UTR       24284625//24981863//26404942 chr12:109039739-109039740(-) m6A 3'UTR       24284625//24981863//26404942 chr12:109039757-109039758(-) m6A 3'UTR       24284625//24981863//26404942 chr12:109039836-109039837(-) m6A 3'UTR       24284625//24981863//26404942 chr12:109039864-109039865(-) m6A 3'UTR       24284625//26404942 chr12:109039876-109039877(-) m6A 3'UTR       24284625//26404942 chr12:109039907-109039908(-) m6A 3'UTR       26404942 chr12:109039942-109039943(-) m6A 3'UTR       26404942 chr12:109040525-109040526(-) m6A 3'UTR//intron       24284625//24981863//26404942//22608085 chr12:109040558-109040559(-) m6A 3'UTR//intron       24284625//24981863//26404942//22608085 chr12:109040604-109040605(-) m6A 3'UTR//intron       24284625//24981863//26404942//22608085 chr12:109040618-109040619(-) m6A 3'UTR//intron       24284625//24981863//26404942//22608085 chr12:109040650-109040651(-) m6A 3'UTR//intron       24284625//24981863//26404942//22608085 chr12:109040672-109040673(-) m6A 3'UTR//intron       26404942 chr12:109040805-109040806(-) m6A 3'UTR//exon//intron       - chr12:109040862-109040863(-) m6A 3'UTR//exon//intron       27773535 chr12:109040914-109040915(-) m6A 3'UTR//exon//intron       24981863//26404942//27773535//22608085 chr12:109040989-109040990(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr12:109041017-109041018(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr12:109041067-109041068(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr12:109041137-109041138(-) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr12:109041205-109041206(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085 chr12:109041245-109041246(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22608085 chr12:109042393-109042394(-) m6A 3'UTR//CDS//exon       24209618//24981863//27773535//27371828//22608085 chr12:109042400-109042401(-) m6A 3'UTR//CDS//exon       24209618//24981863//27773535//27371828//22608085 chr12:109042435-109042436(-) m6A 3'UTR//CDS//exon       24209618//24981863//27773535//27371828 chr12:109042462-109042463(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828 chr12:109042489-109042490(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828 chr12:109042534-109042535(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828 chr12:109043037-109043038(-) m6A exon//intron       - chr12:109046076-109046077(-) m6A 3'UTR//CDS//exon//intron       26404942 chr12:109052559-109052560(-) m6A CDS//exon//intron       26404942 chr12:109052595-109052596(-) m6A CDS//exon//intron       26404942 chr12:109052619-109052620(-) m6A CDS//intron       26404942 chr12:109052640-109052641(-) m6A CDS//intron       26404942 chr12:109052659-109052660(-) m6A CDS//intron       26404942 chr12:109072060-109072061(-) m6A 5'UTR//CDS//exon//intron       26404942//22575960 chr12:109072105-109072106(-) m6A 5'UTR//CDS//exon//intron       26404942//22575960 chr12:109072111-109072112(-) m6A 5'UTR//CDS//exon//intron       26404942//22575960 chr12:109072122-109072123(-) m6A 5'UTR//CDS//exon//intron       26404942 chr12:109095098-109095099(-) m6A 5'UTR//CDS//exon//intron       24284625//24209618//24981863//27371828//27773536 chr12:109095349-109095350(-) m6A exon//intron       - chr12:109124613-109124614(-) m6A 5'UTR//intron       24209618 chr12:109125238-109125239(-) m6A 5'UTR//exon       24209618//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-466	Exosome Serum     18589210 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Cell lines(GBM46|GBM8|HaCaT|K562|MCF-10A|MCF-7|MGG75)|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocytes     -
	CORO1C	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-466
Interactor2: CORO1C

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.