Basic Information:

  VIRBase ID:  

HHID00072066

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3121-3p:  MIMAT0014983          ATG4C:  NM_178221     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3121-3p	ATG4C
miRBase Accession/Entrez ID	MIMAT0014983	84938
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	APG4-C//APG4C//AUTL1//AUTL3

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3121-3p	rs1006143795 chr1:180438334    T/C rs778817728 chr1:180438323    T/C rs887772082 chr1:180438327    C/T rs911596096 chr1:180438331    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ATG4C	chr1:63263549(+) A-I      intronic chr1:63280680(+) A-I      intronic chr1:63280693(+) A-I      intronic chr1:63304193(+) A-I      intronic chr1:63263552(+) A-I      intronic chr1:63280686(+) A-I      intronic chr1:63311502(+) A-I      intronic chr1:63259118(+) A-I      intronic chr1:63280681(+) A-I      intronic chr1:63259121(+) A-I      intronic chr1:63280645(+) A-I      intronic chr1:63280644(+) A-I      intronic chr1:63263555(+) A-I      intronic chr1:63263554(+) A-I      intronic chr1:63267508(+) A-I      intronic chr1:63267518(+) A-I      intronic chr1:63267535(+) A-I      intronic chr1:63267550(+) A-I      intronic chr1:63327085(+) A-I      intronic chr1:63325470(+) A-I      intronic chr1:63312763(+) A-I      intronic chr1:63312733(+) A-I      intronic chr1:63288664(+) A-I      intronic chr1:63312709(+) A-I      intronic chr1:63312670(+) A-I      intronic chr1:63312648(+) A-I      intronic chr1:63312646(+) A-I      intronic chr1:63312576(+) A-I      intronic chr1:63311553(+) A-I      intronic chr1:63311477(+) A-I      intronic chr1:63311476(+) A-I      intronic chr1:63311473(+) A-I      intronic chr1:63311447(+) A-I      intronic chr1:63305944(+) A-I      intronic chr1:63304408(+) A-I      intronic chr1:63291672(+) A-I      intronic chr1:63290731(+) A-I      intronic chr1:63290362(+) A-I      intronic chr1:63262517(+) A-I      intronic chr1:63255229(+) A-I      intronic chr1:63255230(+) A-I      intronic chr1:63255715(+) A-I      intronic chr1:63255725(+) A-I      intronic chr1:63257722(+) A-I      intronic chr1:63257813(+) A-I      intronic chr1:63257833(+) A-I      intronic chr1:63258723(+) A-I      intronic chr1:63263510(+) A-I      intronic chr1:63263617(+) A-I      intronic chr1:63267358(+) A-I      intronic chr1:63267375(+) A-I      intronic chr1:63267380(+) A-I      intronic chr1:63267383(+) A-I      intronic chr1:63267475(+) A-I      intronic chr1:63267479(+) A-I      intronic chr1:63267498(+) A-I      intronic chr1:63257807(+) A-I      intronic chr1:63290857(+) A-I      intronic chr1:63262736(+) A-I      intronic chr1:63312727(+) A-I      intronic chr1:63290602(+) A-I      intronic chr1:63255297(+) A-I      intronic chr1:63304834(+) A-I      intronic chr1:63290792(+) A-I      intronic chr1:63304859(+) A-I      intronic chr1:63311547(+) A-I      intronic chr1:63290786(+) A-I      intronic chr1:63327131(+) A-I      intronic chr1:63255774(+) A-I      intronic chr1:63304330(+) A-I      intronic chr1:63263745(+) A-I      intronic chr1:63311583(+) A-I      intronic chr1:63259141(+) A-I      intronic chr1:63308112(+) A-I      intronic chr1:63281536(+) A-I      intronic chr1:63304964(+) A-I      intronic chr1:63327058(+) A-I      intronic chr1:63255373(+) A-I      intronic chr1:63263625(+) A-I      intronic chr1:63267463(+) A-I      intronic chr1:63304804(+) A-I      intronic chr1:63288772(+) A-I      intronic chr1:63304842(+) A-I      intronic chr1:63327077(+) A-I      intronic chr1:63259104(+) A-I      intronic chr1:63257769(+) A-I      intronic chr1:63304847(+) A-I      intronic chr1:63255367(+) A-I      intronic chr1:63290827(+) A-I      intronic chr1:63259170(+) A-I      intronic chr1:63327089(+) A-I      intronic chr1:63267345(+) A-I      intronic chr1:63267514(+) A-I      intronic chr1:63290480(+) A-I      intronic chr1:63318369(+) A-I      intronic chr1:63262691(+) A-I      intronic chr1:63327059(+) A-I      intronic chr1:63259181(+) A-I      intronic chr1:63312833(+) A-I      intronic chr1:63290760(+) A-I      intronic chr1:63261379(+) A-I      intronic chr1:63312686(+) A-I      intronic chr1:63288706(+) A-I      intronic chr1:63304963(+) A-I      intronic chr1:63325460(+) A-I      intronic chr1:63327035(+) A-I      intronic chr1:63325483(+) A-I      intronic chr1:63257688(+) A-I      intronic chr1:63290408(+) A-I      intronic chr1:63325467(+) A-I      intronic chr1:63257817(+) A-I      intronic chr1:63267482(+) A-I      intronic chr1:63255785(+) A-I      intronic chr1:63304229(+) A-I      intronic chr1:63290439(+) A-I      intronic chr1:63292011(+) A-I      intronic chr1:63259027(+) A-I      intronic chr1:63255919(+) A-I      intronic chr1:63290389(+) A-I      intronic chr1:63290530(+) A-I      intronic chr1:63290438(+) A-I      intronic chr1:63288771(+) A-I      intronic chr1:63290853(+) A-I      intronic chr1:63304855(+) A-I      intronic chr1:63288679(+) A-I      intronic chr1:63325447(+) A-I      intronic chr1:63280478(+) A-I      intronic chr1:63303574(+) A-I      intronic chr1:63291605(+) A-I      intronic chr1:63267189(+) A-I      intronic chr1:63259198(+) A-I      intronic chr1:63327178(+) A-I      intronic chr1:63280472(+) A-I      intronic chr1:63263620(+) A-I      intronic chr1:63264722(+) A-I      intronic chr1:63327061(+) A-I      intronic chr1:63290472(+) A-I      intronic chr1:63290549(+) A-I      intronic chr1:63303587(+) A-I      intronic chr1:63290856(+) A-I      intronic chr1:63327136(+) A-I      intronic chr1:63327119(+) A-I      intronic chr1:63259068(+) A-I      intronic chr1:63264636(+) A-I      intronic chr1:63305905(+) A-I      intronic chr1:63267466(+) A-I      intronic chr1:63308115(+) A-I      intronic chr1:63303579(+) A-I      intronic chr1:63291653(+) A-I      intronic chr1:63257797(+) A-I      intronic chr1:63255429(+) A-I      intronic chr1:63292083(+) A-I      intronic chr1:63267655(+) A-I      intronic chr1:63304331(+) A-I      intronic chr1:63304357(+) A-I      intronic chr1:63263517(+) A-I      intronic chr1:63304810(+) A-I      intronic chr1:63259106(+) A-I      intronic chr1:63264668(+) A-I      intronic chr1:63327141(+) A-I      intronic chr1:63305887(+) A-I      intronic chr1:63288670(+) A-I      intronic chr1:63281495(+) A-I      intronic chr1:63311562(+) A-I      intronic chr1:63259127(+) A-I      intronic chr1:63292094(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ATG4C	chr1:63255367(+) A-G intron -    22484847 chr1:63255373(+) A-G intron -    22484847 chr1:63255774(+) A-G intron -    22484847 chr1:63255785(+) A-G intron -    22484847 chr1:63257769(+) A-G intron -    22484847 chr1:63257797(+) A-G intron -    22484847 chr1:63257807(+) A-G intron -    22484847 chr1:63280472(+) A-G intron -    22484847 chr1:63280478(+) A-G intron -    22484847 chr1:63288771(+) A-G intron -    22484847 chr1:63288772(+) A-G intron -    22484847 chr1:63290408(+) A-G intron -    22484847 chr1:63290438(+) A-G intron -    22484847 chr1:63290439(+) A-G intron -    22484847 chr1:63290472(+) A-G intron -    22484847 chr1:63290480(+) A-G intron -    22484847 chr1:63290786(+) A-G intron -    22484847 chr1:63290792(+) A-G intron -    22484847 chr1:63291653(+) A-G intron -    22484847 chr1:63304229(+) A-G intron -    22484847 chr1:63304331(+) A-G intron -    22484847 chr1:63304804(+) A-G intron -    22484847 chr1:63304964(+) A-G intron -    22484847 chr1:63311547(+) A-G intron -    22484847 chr1:63311562(+) A-G intron -    22484847 chr1:63311583(+) A-G intron -    22484847 chr1:63312686(+) A-G intron -    22484847 chr1:63312727(+) A-G intron -    22484847 chr1:63312833(+) A-G intron -    22484847 chr1:63312858(+) G-A intron -    22484847 chr1:63325467(+) A-G intron -    22484847 chr1:63325483(+) A-G intron -    22484847 chr1:63327119(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ATG4C	chr1:63282401-63282402(+) m6A CDS       24284625//24209618//24981863//22608085 chr1:63282427-63282428(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr1:63282453-63282454(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr1:63284680-63284681(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr1:63284714-63284715(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr1:63284728-63284729(+) m6A CDS       24284625//24209618//25456834//24981863//22608085 chr1:63284797-63284798(+) m6A CDS       24981863//22608085 chr1:63284821-63284822(+) m6A CDS       24981863//22608085 chr1:63329726-63329727(+) m6A CDS       24981863//22608085 chr1:63329762-63329763(+) m6A CDS       24981863//22608085 chr1:63329787-63329788(+) m6A CDS       24981863//22608085 chr1:63329890-63329891(+) m6A 3'UTR       22608085 chr1:63330175-63330176(+) m6A 3'UTR       24981863 chr1:63330220-63330221(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3121-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	ATG4C	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3121-3p
Interactor2: ATG4C

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.