Basic Information:

  VIRBase ID:  

HHID00072045

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3121-3p:  MIMAT0014983          SLC35A5:  NM_001348906     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3121-3p	SLC35A5
miRBase Accession/Entrez ID	MIMAT0014983	55032
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3121-3p	rs1006143795 chr1:180438334    T/C rs778817728 chr1:180438323    T/C rs887772082 chr1:180438327    C/T rs911596096 chr1:180438331    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC35A5	chr3:112286338(+) A-I      intronic chr3:112281453(+) A-I      intronic chr3:112281403(+) A-I      intronic chr3:112286196(+) A-I      intronic chr3:112284552(+) A-I      intronic chr3:112285890(+) A-I      intronic chr3:112285901(+) A-I      intronic chr3:112285907(+) A-I      intronic chr3:112285914(+) A-I      intronic chr3:112281731(+) A-I      intronic chr3:112284453(+) A-I      intronic chr3:112284478(+) A-I      intronic chr3:112286301(+) A-I      intronic chr3:112286386(+) A-I      intronic chr3:112286444(+) A-I      intronic chr3:112286315(+) A-I      intronic chr3:112286432(+) A-I      intronic chr3:112285958(+) A-I      intronic chr3:112295184(+) A-I      intronic chr3:112285916(+) A-I      intronic chr3:112286279(+) A-I      intronic chr3:112285952(+) A-I      intronic chr3:112284449(+) A-I      intronic chr3:112286240(+) A-I      intronic chr3:112286414(+) A-I      intronic chr3:112284391(+) A-I      intronic chr3:112286365(+) A-I      intronic chr3:112286257(+) A-I      intronic chr3:112284504(+) A-I      intronic chr3:112285819(+) A-I      intronic chr3:112286205(+) A-I      intronic chr3:112286060(+) A-I      intronic chr3:112285816(+) A-I      intronic chr3:112284528(+) A-I      intronic chr3:112286305(+) A-I      intronic chr3:112281725(+) A-I      intronic chr3:112284383(+) A-I      intronic chr3:112285922(+) A-I      intronic chr3:112286413(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SLC35A5	chr3:112284383(+) A-G intron -    22484847 chr3:112285816(+) A-G intron -    22484847 chr3:112285910(+) A-G intron -    22484847 chr3:112285922(+) A-G intron -    22484847 chr3:112285952(+) A-G intron -    22484847 chr3:112285958(+) A-G intron -    22484847 chr3:112286060(+) A-G intron -    22484847 chr3:112286210(+) A-G intron -    22484847 chr3:112286234(+) A-G intron -    22484847 chr3:112286324(+) A-G intron -    22484847 chr3:112286432(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC35A5	chr3:112280609-112280610(+) m6A 5'UTR       25456834//27371828//27773536 chr3:112280614-112280615(+) m6A 5'UTR       25456834//27371828//27773536 chr3:112280662-112280663(+) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536 chr3:112281027-112281028(+) m6A 5'UTR//intron       27773535 chr3:112299403-112299404(+) m6A CDS//exon       24284625//24209618//24981863//22575960//22608085 chr3:112299465-112299466(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr3:112299471-112299472(+) m6A CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085 chr3:112299571-112299572(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:112299594-112299595(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:112299616-112299617(+) m6A CDS//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr3:112299736-112299737(+) m6A CDS//exon//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr3:112299766-112299767(+) m6A CDS//exon//intron       24284625//24209618//24981863//22575960//22608085 chr3:112299773-112299774(+) m6A CDS//exon//intron       24284625//24209618//24981863//22575960//22608085 chr3:112299847-112299848(+) m6A CDS//exon//intron       24284625//24209618//24981863//22575960//22608085 chr3:112302090-112302091(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3121-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	SLC35A5	Exosome Blood     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3121-3p
Interactor2: SLC35A5

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.