Basic Information:

  VIRBase ID:  

HHID00072038

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3121-3p:  MIMAT0014983          TMOD2:  NM_001142885     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3121-3p	TMOD2
miRBase Accession/Entrez ID	MIMAT0014983	29767
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	N-TMOD//NTMOD

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3121-3p	rs1006143795 chr1:180438334    T/C rs778817728 chr1:180438323    T/C rs887772082 chr1:180438327    C/T rs911596096 chr1:180438331    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	TMOD2	chr15:52065932(+) A-I      NonSyn:Lys->Glu chr15:52107370(+) A-I      3'UTR chr15:52107328(+) A-I      3'UTR chr15:52107371(+) A-I      3'UTR chr15:52107348(+) A-I      3'UTR chr15:52107361(+) A-I      3'UTR chr15:52107365(+) A-I      3'UTR chr15:52057269(+) A-I      intronic chr15:52057278(+) A-I      intronic chr15:52092570(+) A-I      intronic chr15:52092571(+) A-I      intronic chr15:52092574(+) A-I      intronic chr15:52092590(+) A-I      intronic chr15:52093032(+) A-I      intronic chr15:52057298(+) A-I      intronic chr15:52092654(+) A-I      intronic chr15:52092983(+) A-I      intronic chr15:52095517(+) A-I      intronic chr15:52052892(+) A-I      intronic chr15:52071601(+) A-I      intronic chr15:52070951(+) A-I      intronic chr15:52054549(+) A-I      intronic chr15:52056347(+) A-I      intronic chr15:52052864(+) A-I      intronic chr15:52053834(+) A-I      intronic chr15:52050125(+) A-I      intronic chr15:52070981(+) A-I      intronic chr15:52055262(+) A-I      intronic chr15:52093274(+) A-I      intronic chr15:52092934(+) A-I      intronic chr15:52057301(+) A-I      intronic chr15:52092720(+) A-I      intronic chr15:52052744(+) A-I      intronic chr15:52055150(+) A-I      intronic chr15:52092477(+) A-I      intronic chr15:52093020(+) A-I      intronic chr15:52092989(+) A-I      intronic chr15:52092715(+) A-I      intronic chr15:52053804(+) A-I      intronic chr15:52097337(+) A-I      intronic chr15:52053669(+) A-I      intronic chr15:52054582(+) A-I      intronic chr15:52053753(+) A-I      intronic chr15:52092665(+) A-I      intronic chr15:52054584(+) A-I      intronic chr15:52053745(+) A-I      intronic chr15:52052837(+) A-I      intronic chr15:52094043(+) A-I      intronic chr15:52055250(+) A-I      intronic chr15:52053742(+) A-I      intronic chr15:52052882(+) A-I      intronic chr15:52093033(+) A-I      intronic chr15:52055235(+) A-I      intronic chr15:52093003(+) A-I      intronic chr15:52092507(+) A-I      intronic chr15:52055164(+) A-I      intronic chr15:52052909(+) A-I      intronic chr15:52056494(+) A-I      intronic chr15:52059406(+) A-I      intronic chr15:52053501(+) A-I      intronic chr15:52050108(+) A-I      intronic chr15:52093042(+) A-I      intronic chr15:52056509(+) A-I      intronic chr15:52054552(+) A-I      intronic chr15:52054440(+) A-I      intronic chr15:52071224(+) A-I      intronic chr15:52053841(+) A-I      intronic chr15:52054568(+) A-I      intronic chr15:52055244(+) A-I      intronic chr15:52052769(+) A-I      intronic chr15:52055261(+) A-I      intronic chr15:52055197(+) A-I      intronic chr15:52056429(+) A-I      intronic chr15:52092939(+) A-I      intronic chr15:52092476(+) A-I      intronic chr15:52055410(+) A-I      intronic chr15:52052883(+) A-I      intronic chr15:52075425(+) A-I      intronic chr15:52056343(+) A-I      intronic chr15:52075412(+) A-I      intronic chr15:52053810(+) A-I      intronic chr15:52092927(+) A-I      intronic chr15:52075817(+) A-I      intronic chr15:52054399(+) A-I      intronic chr15:52056339(+) A-I      intronic chr15:52107329(+) A-I      3'UTR chr15:52107400(+) A-I      3'UTR chr15:52104013(+) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	TMOD2	chr15:52052744(+) A-I intron -    15342557 chr15:52052769(+) A-I intron -    15342557 chr15:52052818(+) A-I intron -    15342557 chr15:52052882(+) A-I intron -    15342557 chr15:52052883(+) A-I intron -    15342557 chr15:52052892(+) A-I intron -    15342557 chr15:52052909(+) A-I intron -    15342557 chr15:52053501(+) A-I intron -    15342557 chr15:52053753(+) A-I intron -    15342557

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TMOD2	chr15:52100640-52100641(+) m6A CDS       24981863 chr15:52100651-52100652(+) m6A 3'UTR       24981863 chr15:52100699-52100700(+) m6A 3'UTR       24981863 chr15:52100705-52100706(+) m6A 3'UTR       24981863 chr15:52100727-52100728(+) m6A 3'UTR       24981863 chr15:52104409-52104410(+) m6A 3'UTR       24981863 chr15:52104443-52104444(+) m6A 3'UTR       24981863 chr15:52104463-52104464(+) m6A 3'UTR       24981863 chr15:52104508-52104509(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3121-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	TMOD2	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3121-3p
Interactor2: TMOD2

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.