Basic Information:

  VIRBase ID:  

HHID00072037

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3121-3p:  MIMAT0014983          CD274:  NR_052005     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3121-3p	CD274
miRBase Accession/Entrez ID	MIMAT0014983	29126
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	B7-H//B7H1//hPD-L1//PD-L1//PDCD1L1//PDCD1LG1//PDL1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3121-3p	rs1006143795 chr1:180438334    T/C rs778817728 chr1:180438323    T/C rs887772082 chr1:180438327    C/T rs911596096 chr1:180438331    G/C

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CD274	chr9:5457102-5457103(+) m6A CDS//exon//intron       24981863 chr9:5457163-5457164(+) m6A CDS//exon//intron       24981863 chr9:5457171-5457172(+) m6A CDS//exon//intron       24981863 chr9:5457213-5457214(+) m6A CDS//exon//intron       24981863 chr9:5457243-5457244(+) m6A CDS//exon//intron       24981863 chr9:5457271-5457272(+) m6A CDS//exon//intron       24981863 chr9:5457294-5457295(+) m6A CDS//exon//intron       24981863 chr9:5462940-5462941(+) m6A CDS//exon       24981863 chr9:5462973-5462974(+) m6A CDS//exon//intron       24981863 chr9:5466811-5466812(+) m6A CDS//exon       24981863 chr9:5467874-5467875(+) m6A 3'UTR       24981863 chr9:5467979-5467980(+) m6A 3'UTR       24981863 chr9:5468008-5468009(+) m6A 3'UTR       24981863 chr9:5468052-5468053(+) m6A 3'UTR       24981863 chr9:5468071-5468072(+) m6A 3'UTR       24981863 chr9:5468138-5468139(+) m6A 3'UTR       24981863 chr9:5468294-5468295(+) m6A 3'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3121-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	CD274	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3121-3p
Interactor2: CD274

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.