Basic Information:

  VIRBase ID:  

HHID00072033

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3121-3p:  MIMAT0014983          DAPP1:  NM_001306151     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3121-3p	DAPP1
miRBase Accession/Entrez ID	MIMAT0014983	27071
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	BAM32

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3121-3p	rs1006143795 chr1:180438334    T/C rs778817728 chr1:180438323    T/C rs887772082 chr1:180438327    C/T rs911596096 chr1:180438331    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	DAPP1	chr4:100790948(+) A-I      3'UTR chr4:100790809(+) A-I      3'UTR chr4:100790927(+) A-I      3'UTR chr4:100790956(+) A-I      3'UTR chr4:100790967(+) A-I      3'UTR chr4:100790926(+) A-I      3'UTR chr4:100790906(+) A-I      3'UTR chr4:100790929(+) A-I      3'UTR chr4:100790940(+) A-I      3'UTR chr4:100790922(+) A-I      3'UTR chr4:100790931(+) A-I      3'UTR chr4:100771402(+) A-I      intronic chr4:100756192(+) A-I      intronic chr4:100790831(+) A-I      3'UTR chr4:100790886(+) A-I      3'UTR chr4:100790925(+) A-I      3'UTR chr4:100790885(+) A-I      3'UTR chr4:100769660(+) A-I      intronic chr4:100769483(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	DAPP1	chr4:100751457(+) G-T intron -    22484847 chr4:100756192(+) A-G intron -    22484847 chr4:100761141(+) T-C intron -    22484847 chr4:100764011(+) T-C intron -    22484847 chr4:100769483(+) A-G intron -    22484847 chr4:100769572(+) A-G intron -    22484847 chr4:100769593(+) A-G intron -    22484847 chr4:100769660(+) A-G intron -    22484847 chr4:100771499(+) A-G intron -    22484847 chr4:100772900(+) T-C intron -    22484847 chr4:100790885(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	DAPP1	chr4:100787209-100787210(+) m6A CDS//exon       - chr4:100787230-100787231(+) m6A CDS//exon       - chr4:100787720-100787721(+) m6A CDS//intron       - chr4:100787770-100787771(+) m6A 3'UTR//intron       - chr4:100789287-100789288(+) m6A 3'UTR//CDS//exon       - chr4:100789428-100789429(+) m6A 3'UTR//exon       - chr4:100789453-100789454(+) m6A 3'UTR//exon       - chr4:100789480-100789481(+) m6A 3'UTR//exon       - chr4:100789543-100789544(+) m6A 3'UTR//exon       - chr4:100789581-100789582(+) m6A 3'UTR//exon       - chr4:100789612-100789613(+) m6A 3'UTR//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3121-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	DAPP1	Exosome Blood     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3121-3p
Interactor2: DAPP1

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.