Basic Information:

  VIRBase ID:  

HHID00072019

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3121-3p:  MIMAT0014983          KIF23:  NR_160295     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3121-3p	KIF23
miRBase Accession/Entrez ID	MIMAT0014983	9493
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	CHO1//KNSL5//MKLP-1//MKLP1

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3121-3p	rs1006143795 chr1:180438334    T/C rs778817728 chr1:180438323    T/C rs887772082 chr1:180438327    C/T rs911596096 chr1:180438331    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	KIF23	chr15:69716289(+) A-I      intronic chr15:69722158(+) A-I      intronic chr15:69718914(+) A-I      intronic chr15:69721829(+) A-I      intronic chr15:69722159(+) A-I      intronic chr15:69722140(+) A-I      intronic chr15:69735862(+) A-I      intronic chr15:69722297(+) A-I      intronic chr15:69722176(+) A-I      intronic chr15:69721884(+) A-I      intronic chr15:69731033(+) A-I      intronic chr15:69721683(+) A-I      intronic chr15:69718910(+) A-I      intronic chr15:69720505(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	KIF23	chr15:69718997(+) T-A intron -    22484847 chr15:69718999(+) C-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	KIF23	chr15:69708342-69708343(+) m6A CDS//exon       24981863//22575960 chr15:69708353-69708354(+) m6A CDS//exon       24981863//22575960 chr15:69708382-69708383(+) m6A CDS//exon       22575960 chr15:69708391-69708392(+) m6A CDS//exon       22575960 chr15:69719806-69719807(+) m6A CDS//intron       24981863 chr15:69721457-69721458(+) m6A 3'UTR//CDS//exon       24981863 chr15:69721509-69721510(+) m6A 3'UTR//CDS//exon       24981863 chr15:69721518-69721519(+) m6A 3'UTR//CDS//exon       24981863 chr15:69721534-69721535(+) m6A 3'UTR//CDS//exon       24981863 chr15:69727853-69727854(+) m6A 3'UTR//CDS//exon       24981863 chr15:69727878-69727879(+) m6A 3'UTR//CDS//exon       24981863 chr15:69727892-69727893(+) m6A 3'UTR//CDS//exon       24981863 chr15:69728033-69728034(+) m6A 3'UTR//CDS//exon       24981863 chr15:69728078-69728079(+) m6A 3'UTR//CDS//exon       24981863 chr15:69728105-69728106(+) m6A 3'UTR//CDS//exon       24981863 chr15:69728982-69728983(+) m6A 3'UTR//CDS//exon       27773535 chr15:69729056-69729057(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr15:69730643-69730644(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr15:69730659-69730660(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr15:69730689-69730690(+) m6A 3'UTR//CDS//exon       24981863//27773535 chr15:69730724-69730725(+) m6A 3'UTR//CDS       24981863//27773535 chr15:69730729-69730730(+) m6A 3'UTR//CDS       24981863//27773535 chr15:69732260-69732261(+) m6A 3'UTR//CDS       24981863//27773535 chr15:69732304-69732305(+) m6A 3'UTR//CDS       24981863//27773535//22575960 chr15:69732311-69732312(+) m6A 3'UTR//CDS       24981863//27773535//22575960 chr15:69732318-69732319(+) m6A 3'UTR//CDS       24981863//27773535//22575960 chr15:69732325-69732326(+) m6A 3'UTR//CDS       24981863//27773535//22575960 chr15:69732666-69732667(+) m6A 3'UTR//CDS       24981863 chr15:69732687-69732688(+) m6A 3'UTR//CDS       24981863 chr15:69732714-69732715(+) m6A 3'UTR//CDS       24981863 chr15:69733310-69733311(+) m6A 3'UTR//CDS//intron       - chr15:69733326-69733327(+) m6A 3'UTR//CDS//intron       - chr15:69733349-69733350(+) m6A 3'UTR//CDS//intron       24981863 chr15:69737198-69737199(+) m6A CDS//exon//intron       26404942 chr15:69737236-69737237(+) m6A CDS//exon//intron       26404942 chr15:69737242-69737243(+) m6A CDS//exon//intron       - chr15:69740264-69740265(+) m6A 3'UTR       26404942 chr15:69740319-69740320(+) m6A 3'UTR       26404942 chr15:69740337-69740338(+) m6A 3'UTR       26404942 chr15:69740571-69740572(+) m6A 3'UTR       27773535 chr15:69740612-69740613(+) m6A 3'UTR       27773535 chr15:69740629-69740630(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3121-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	KIF23	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3121-3p
Interactor2: KIF23

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.