Basic Information:

  VIRBase ID:  

HHID00072007

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3121-3p:  MIMAT0014983          SNRPA:  NM_004596     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3121-3p	SNRPA
miRBase Accession/Entrez ID	MIMAT0014983	6626
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	Mud1//U1-A//U1A

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3121-3p	rs1006143795 chr1:180438334    T/C rs778817728 chr1:180438323    T/C rs887772082 chr1:180438327    C/T rs911596096 chr1:180438331    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SNRPA	chr19:41265190(+) A-I      intronic chr19:41265142(+) A-I      intronic chr19:41265140(+) A-I      intronic chr19:41259040(+) A-I      intronic chr19:41258996(+) A-I      intronic chr19:41261422(+) A-I      intronic chr19:41259363(+) A-I      intronic chr19:41260060(+) A-I      intronic chr19:41259896(+) A-I      intronic chr19:41264732(+) A-I      intronic chr19:41264749(+) A-I      intronic chr19:41264771(+) A-I      intronic chr19:41266032(+) A-I      intronic chr19:41264903(+) A-I      intronic chr19:41260088(+) A-I      intronic chr19:41260083(+) A-I      intronic chr19:41260078(+) A-I      intronic chr19:41264992(+) A-I      intronic chr19:41265957(+) A-I      intronic chr19:41263672(+) A-I      intronic chr19:41266172(+) A-I      intronic chr19:41263695(+) A-I      intronic chr19:41266711(+) A-I      intronic chr19:41259379(+) A-I      intronic chr19:41259381(+) A-I      intronic chr19:41261968(+) A-I      intronic chr19:41261949(+) A-I      intronic chr19:41264134(+) A-I      intronic chr19:41259401(+) A-I      intronic chr19:41259811(+) A-I      intronic chr19:41262016(+) A-I      intronic chr19:41262010(+) A-I      intronic chr19:41259137(+) A-I      intronic chr19:41259133(+) A-I      intronic chr19:41259104(+) A-I      intronic chr19:41259074(+) A-I      intronic chr19:41259035(+) A-I      intronic chr19:41259005(+) A-I      intronic chr19:41259004(+) A-I      intronic chr19:41258119(+) A-I      intronic chr19:41258095(+) A-I      intronic chr19:41263696(+) A-I      intronic chr19:41263958(+) A-I      intronic chr19:41263972(+) A-I      intronic chr19:41264046(+) A-I      intronic chr19:41261944(+) A-I      intronic chr19:41261447(+) A-I      intronic chr19:41258606(+) A-I      intronic chr19:41263922(+) A-I      intronic chr19:41261264(+) A-I      intronic chr19:41261413(+) A-I      intronic chr19:41260248(+) A-I      intronic chr19:41258131(+) A-I      intronic chr19:41262440(+) A-I      intronic chr19:41259763(+) A-I      intronic chr19:41260205(+) A-I      intronic chr19:41266823(+) A-I      intronic chr19:41265165(+) A-I      intronic chr19:41262354(+) A-I      intronic chr19:41261483(+) A-I      intronic chr19:41259189(+) A-I      intronic chr19:41260191(+) A-I      intronic chr19:41261045(+) A-I      intronic chr19:41264993(+) A-I      intronic chr19:41266682(+) A-I      intronic chr19:41263615(+) A-I      intronic chr19:41259782(+) A-I      intronic chr19:41264966(+) A-I      intronic chr19:41264124(+) A-I      intronic chr19:41259474(+) A-I      intronic chr19:41262013(+) A-I      intronic chr19:41258419(+) A-I      intronic chr19:41266991(+) A-I      intronic chr19:41259102(+) A-I      intronic chr19:41261940(+) A-I      intronic chr19:41266947(+) A-I      intronic chr19:41261086(+) A-I      intronic chr19:41260279(+) A-I      intronic chr19:41266790(+) A-I      intronic chr19:41266723(+) A-I      intronic chr19:41263767(+) A-I      intronic chr19:41264835(+) A-I      intronic chr19:41266778(+) A-I      intronic chr19:41259872(+) A-I      intronic chr19:41261360(+) A-I      intronic chr19:41261123(+) A-I      intronic chr19:41260109(+) A-I      intronic chr19:41264052(+) A-I      intronic chr19:41261927(+) A-I      intronic chr19:41263753(+) A-I      intronic chr19:41261124(+) A-I      intronic chr19:41261446(+) A-I      intronic chr19:41259171(+) A-I      intronic chr19:41263713(+) A-I      intronic chr19:41259824(+) A-I      intronic chr19:41261082(+) A-I      intronic chr19:41259485(+) A-I      intronic chr19:41259174(+) A-I      intronic chr19:41264055(+) A-I      intronic chr19:41261342(+) A-I      intronic chr19:41266009(+) A-I      intronic chr19:41266162(+) A-I      intronic chr19:41263638(+) A-I      intronic chr19:41266737(+) A-I      intronic chr19:41259106(+) A-I      intronic chr19:41266093(+) A-I      intronic chr19:41262027(+) A-I      intronic chr19:41262084(+) A-I      intronic chr19:41266610(+) A-I      intronic chr19:41258399(+) A-I      intronic chr19:41264970(+) A-I      intronic chr19:41259752(+) A-I      intronic chr19:41266589(+) A-I      intronic chr19:41266178(+) A-I      intronic chr19:41261378(+) A-I      intronic chr19:41262421(+) A-I      intronic chr19:41259848(+) A-I      intronic chr19:41261062(+) A-I      intronic chr19:41262024(+) A-I      intronic chr19:41262246(+) A-I      intronic chr19:41258446(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SNRPA	chr19:41262118(+) A-I intron -    22327324 chr19:41264055(+) A-I intron -    22327324 chr19:41259101(+) A-G intron -    22484847 chr19:41259102(+) A-G intron -    22484847 chr19:41262013(+) A-G intron -    22484847 chr19:41262024(+) A-G intron -    22484847 chr19:41262118(+) A-G intron -    22484847 chr19:41262119(+) A-G intron -    22484847 chr19:41262319(+) A-G intron -    22484847 chr19:41264055(+) A-G intron -    22484847 chr19:41266662(+) A-G intron -    22484847 chr19:41266947(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SNRPA	chr19:41256556-41256557(+) m6A 5'UTR       25456834 chr19:41256585-41256586(+) m6A 5'UTR       25456834//24981863 chr19:41256823-41256824(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863//22608085 chr19:41256923-41256924(+) m6A 5'UTR//exon//intron       24284625//25456834//24981863//22608085 chr19:41256952-41256953(+) m6A 5'UTR//exon//intron       24284625//24981863 chr19:41257239-41257240(+) m6A 5'UTR//exon//intron       24981863//27773535 chr19:41257256-41257257(+) m6A 5'UTR//exon//intron       24981863//27773535 chr19:41257291-41257292(+) m6A 5'UTR//exon//intron       24981863//27773535 chr19:41257328-41257329(+) m6A CDS//exon//intron       24981863//26404942//27773535 chr19:41263402-41263403(+) m6A CDS//exon//intron       22575960 chr19:41264767-41264768(+) m6A 3'UTR//intron       22575960 chr19:41265353-41265354(+) m6A 3'UTR//CDS//exon       22575960 chr19:41265402-41265403(+) m6A 3'UTR//CDS//exon       22575960 chr19:41265440-41265441(+) m6A 3'UTR//CDS//exon       - chr19:41265533-41265534(+) m6A exon//intron       - chr19:41268957-41268958(+) m6A CDS//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3121-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	SNRPA	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3121-3p
Interactor2: SNRPA

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	CDS
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.