Basic Information:

  VIRBase ID:  

HHID00072001

  Virus:  

Human gammaherpesvirus 4 (Epstein-Barr virus, EPV)

  Host:  

Homo sapiens

  Confidence Score:  

0.4752

  Interaction Type:  

Host-Host interaction

  Predicted Binding:

 

      hsa-miR-3121-3p:  MIMAT0014983          SMAD5:  NM_005903     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hsa-miR-3121-3p	SMAD5
miRBase Accession/Entrez ID	MIMAT0014983	4090
Organism	Homo sapiens	Homo sapiens
Category	miRNA	mRNA
Alias	-	DWFC//JV5-1//MADH5

ncRNA SNP information:

Resource	Symbol	SNP ID	SNP Position	Ref/Alt
miRNASNP-v3	hsa-miR-3121-3p	rs1006143795 chr1:180438334    T/C rs778817728 chr1:180438323    T/C rs887772082 chr1:180438327    C/T rs911596096 chr1:180438331    G/C

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SMAD5	chr5:135503710(+) A-I      intronic chr5:135503297(+) A-I      intronic chr5:135503769(+) A-I      intronic chr5:135503777(+) A-I      intronic chr5:135503713(+) A-I      intronic chr5:135503238(+) A-I      intronic chr5:135503436(+) A-I      intronic chr5:135503804(+) A-I      intronic chr5:135503307(+) A-I      intronic chr5:135472648(+) A-I      intronic chr5:135471931(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SMAD5	chr5:135503195(+) A-G intron -    22484847 chr5:135503238(+) A-G intron -    22484847 chr5:135503286(+) A-G intron -    22484847 chr5:135503307(+) A-G intron -    22484847 chr5:135503711(+) A-G intron -    22484847 chr5:135503713(+) A-G intron -    22484847 chr5:135514463(+) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SMAD5	chr5:135468927-135468928(+) m6A exon//intron       24284625//24209618//24981863//22575960//22608085 chr5:135468963-135468964(+) m6A exon//intron       24284625//24209618//24981863//22608085 chr5:135488389-135488390(+) m6A 5'UTR//exon//intron       24284625//24209618//24981863//22608085 chr5:135488404-135488405(+) m6A 5'UTR//exon//intron       24284625//24209618//24981863//22608085 chr5:135489349-135489350(+) m6A 5'UTR//exon//intron       24284625//24209618//24981863//22575960//22608085 chr5:135489362-135489363(+) m6A 5'UTR//exon//intron       24284625//24209618//24981863//22575960//22608085 chr5:135489514-135489515(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:135489571-135489572(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:135489601-135489602(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:135489628-135489629(+) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr5:135496616-135496617(+) m6A CDS//intron       24284625//24981863//27773535 chr5:135496632-135496633(+) m6A CDS//intron       24284625//24981863//27773535 chr5:135496709-135496710(+) m6A CDS//intron       24284625//24981863 chr5:135496770-135496771(+) m6A CDS//intron       24284625//24981863 chr5:135510142-135510143(+) m6A CDS//exon       24284625//24981863 chr5:135513145-135513146(+) m6A CDS//intron       24284625//24981863//22608085 chr5:135513203-135513204(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr5:135513224-135513225(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr5:135513259-135513260(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr5:135514661-135514662(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr5:135514730-135514731(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr5:135514745-135514746(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr5:135514750-135514751(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr5:135514755-135514756(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr5:135514760-135514761(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr5:135514784-135514785(+) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//22608085 chr5:135514856-135514857(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr5:135514878-135514879(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr5:135514888-135514889(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr5:135514937-135514938(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr5:135514944-135514945(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085 chr5:135514975-135514976(+) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	hsa-miR-3121-3p	Exosome Plasma     23663360 Exosome Breast milk|Cell lines|Epididymal epithelial cells|Osteoblast|Plasma|Primary glioblastoma neurosphere cells|Primary keratinocyte|Saliva|Serum|Urine     - Microvesicle Mesenchymal stem cells     -
	SMAD5	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hsa-miR-3121-3p
Interactor2: SMAD5

Evidence Support:

Weak-Evidence	PAR-CLIP
Support Database	ViRBase

References:

PMID	22291592	Target region	3'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	EF3D-AGO2 cells//LCL35 cells//LCL-BAC cells//LCL-BAC-D1 cells//LCL-BAC-D3 cells	Interactor2 expression	None
Description	We identified 7, 827 miRNA-interaction sites in 3, 492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs.Table S6: High confidence miRNA-interaction sites in 3'UTRs.